| Entry |
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| Name |
xanthine dioxygenase;
XanA;
alpha-ketoglutarate-dependent xanthine hydroxylase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
xanthine,2-oxoglutarate:oxygen oxidoreductase
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| Reaction(IUBMB) |
xanthine + 2-oxoglutarate + O2 = urate + succinate + CO2 [RN: R10920]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Fe2+ and L-ascorbate. The enzyme, which was characterized from fungi, is specific for xanthine.
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| History |
EC 1.14.11.48 created 2015
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| Reference |
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| Authors |
Cultrone A, Scazzocchio C, Rochet M, Montero-Moran G, Drevet C, Fernandez-Martin R |
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| Title |
Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via alpha-ketoglutarate-dependent dioxygenases. |
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| Journal |
Mol. Microbiol. 57 (2005) 276-90. |
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| Reference |
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| Authors |
Montero-Moran GM, Li M, Rendon-Huerta E, Jourdan F, Lowe DJ, Stumpff-Kane AW, Feig M, Scazzocchio C, Hausinger RP |
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| Title |
Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans. |
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| Journal |
Biochemistry. 46 (2007) 5293-304. |
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| Reference |
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| Authors |
Li M, Muller TA, Fraser BA, Hausinger RP |
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| Title |
Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans. |
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| Journal |
Arch. Biochem. Biophys. 470 (2008) 44-53. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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