| Entry |
|
|---|
| Name |
uridine-5'-phosphate dioxygenase;
lipL (gene name)
|
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
 |
|---|
| Sysname |
UMP,2-oxoglutarate:oxygen oxidoreductase
|
|---|
| Reaction(IUBMB) |
UMP + 2-oxoglutarate + O2 = 5'-dehydrouridine + succinate + CO2 + phosphate [RN: R11053]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
The enzyme catalyses a net dephosphorylation and oxidation of UMP to generate 5'-dehydrouridine, the first intermediate in the biosynthesis of the unusual aminoribosyl moiety found in several C7-furanosyl nucleosides such as A-90289s, caprazamycins, liposidomycins, muraymycins and FR-900453. Requires Fe2+.
|
|---|
| History |
EC 1.14.11.49 created 2015
|
|---|
| Reference |
|
|---|
| Authors |
Yang Z, Chi X, Funabashi M, Baba S, Nonaka K, Pahari P, Unrine J, Jacobsen JM, Elliott GI, Rohr J, Van Lanen SG |
|---|
| Title |
Characterization of LipL as a non-heme, Fe(II)-dependent alpha-ketoglutarate:UMP dioxygenase that generates uridine-5'-aldehyde during A-90289 biosynthesis. |
|---|
| Journal |
J. Biol. Chem. 286 (2011) 7885-92. |
|---|
| Reference |
|
|---|
| Authors |
Yang Z, Unrine J, Nonaka K, Van Lanen SG |
|---|
| Title |
Fe(II)-dependent, uridine-5'-monophosphate alpha-ketoglutarate dioxygenases in the synthesis of 5'-modified nucleosides. |
|---|
| Journal |
Methods. Enzymol. 516 (2012) 153-68. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
|---|
| LinkDB |
 |
|---|
