| Entry |
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| Name |
(-)-deoxypodophyllotoxin synthase;
2-ODD (gene name)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
(-)-yatein,2-oxoglutarate:oxygen oxidoreductase (ring-forming)
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| Reaction(IUBMB) |
(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + succinate + CO2 + H2O [RN: R11210]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme, characterized from the plant Sinopodophyllum hexandrum, is involved in the biosynthetic pathway of podophyllotoxin, a non-alkaloid toxin lignan whose derivatives are important anticancer drugs. It catalyses the closure of the central six-membered ring in the aryltetralin scaffold.
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| History |
EC 1.14.11.50 created 2016
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| Orthology |
| (-)-deoxypodophyllotoxin synthase |
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| Reference |
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| Authors |
Lau W, Sattely ES |
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| Title |
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone. |
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| Journal |
Science. 349 (2015) 1224-8. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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