| Entry |
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| Name |
validamycin A dioxygenase;
vldW (gene name)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
validamycin-A,2-oxoglutarate:oxygen oxidoreductase (6'-hydroxylating)
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| Reaction(IUBMB) |
validamycin A + 2-oxoglutarate + O2 = validamycin B + succinate + CO2 [RN: R11340]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme was characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus. Requires Fe2+.
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| History |
EC 1.14.11.52 created 2016
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| Pathway |
| Acarbose and validamycin biosynthesis | | Biosynthesis of antibiotics |
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| Orthology |
| validamycin A dioxygenase |
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| Genes |
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| Reference |
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| Authors |
Almabruk KH, Asamizu S, Chang A, Varghese SG, Mahmud T |
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| Title |
The alpha-ketoglutarate/Fe(II)-dependent dioxygenase VldW is responsible for the formation of validamycin B. |
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| Journal |
Chembiochem. 13 (2012) 2209-11. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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