| Entry |
|
|---|
| Name |
ectoine hydroxylase;
ectD (gene name);
ectoine dioxygenase
|
|---|
| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
 |
|---|
| Sysname |
ectoine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
|
|---|
| Reaction(IUBMB) |
ectoine + 2-oxoglutarate + O2 = 5-hydroxyectoine + succinate + CO2 [RN: R08050]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
Requires Fe2+ and ascorbate. The enzyme, found in bacteria, is specific for ectoine.
|
|---|
| History |
EC 1.14.11.55 created 2017
|
|---|
| Pathway |
| Glycine, serine and threonine metabolism |
|
|---|
| Orthology |
|
|---|
| Genes |
PAO: | | PSA: | | PSZ: | | PSR: | | PSC: | | PSJ: | | PSH: | | PSTU: | | PSTT: | | PBM: | | AHL: | | PLZ: | | MAQ: | | MHC: | | MAD: | | MSR: | | MSX: | | MARI: | | MLQ: | | AMAA: | | AMAL: | | AMAE: | | AMAO: | | AMAI: | | CELL: | | SPOI: | | ZAL: | | MAH: | | CYQ: | | CZA: | | NOC: | | NHL: | | NWA: | | AEH: | | HCH: | | CSA: | | HEL: | | HCS: | | HAK: | | HAM: | | HHU: | | HCO: | | HALO: | | CMAI: | | KUS: | | KMA: | | ABO: | | ADI: | | APAC: | | ALN: | | AXE: | | MMW: | | MARS: | | GSN: | | OCM: | | CNC: | | BSTG: | | BGD: | | BFN: | | PTX: | | BPA: | | BPAR: | | BBR: | | BBM: | | BBH: | | BBX: | | BPT: | | BAV: | | BHO: | | BHM: | | BHZ: | | BTRM: | | BBRO: | | BFZ: | | AXY: | | AXO: | | AXN: | | AXS: | | AXX: | | ADT: | | AIS: | | PUT: | | AKA: | | AMIM: | | CDN: | | AFA: | | POL: | | VAP: | | VPE: | | VPD: | | CSER: | | RTA: | | LIH: | | HYL: | | HAR: | | MMS: | | HHT: | | MNR: | | BEBA: | | ARC: | | SCU: | | AAK: | | BJA: | | BJU: | | BJP: | | BRA: | | BBT: | | BRS: | | AOL: | | BRC: | | BRAD: | | BIC: | | PHL: | | DEQ: | | PSIN: | | RBM: | | PZU: | | SUAM: | | TPRO: | | HNE: | | NPP: | | NPN: | | NRE: | | SAL: | | SPHK: | | SPHP: | | SMAG: | | SMAZ: | | STER: | | SGI: | | SPHI: | | SSY: | | SYB: | | SBD: | | SPMI: | | SPHR: | | BLAS: | | ACR: | | AMV: | | ATI: | | TXI: | | BCL: | | BPF: | | HHD: | | HMN: | | VIR: | | VHL: | | LAO: | | SJE: | | GYM: | | PNP: | | POW: | | MSM: | | MSG: | | MSB: | | MSN: | | MSH: | | MVA: | | MGI: | | MSP: | | MAB: | | MABB: | | MMV: | | MAY: | | MABO: | | MABL: | | MAZ: | | MAK: | | MYS: | | MYC: | | MCHE: | | MIZ: | | MMC: | | MKM: | | MJL: | | MJD: | | MCB: | | MNE: | | MYV: | | MGO: | | MFT: | | MPHL: | | ASD: | | NFA: | | NFR: | | NCY: | | NBR: | | NNO: | | NSL: | | NSR: | | RHA: | | REB: | | ROP: | | ROA: | | REQ: | | RPY: | | RAV: | | RHW: | | GOR: | | GOQ: | | GTA: | | TPR: | | DTM: | | SCO: | | SMA: | | SGR: | | SGB: | | SCB: | | SSX: | | SVL: | | SCT: | | SCY: | | SFA: | | SBH: | | SHY: | | SHO: | | SVE: | | SDV: | | SALB: | | SALS: | | STRP: | | SFI: | | SCI: | | SRC: | | SALU: | | SALL: | | SLV: | | SGU: | | SVT: | | STRE: | | SCW: | | SLD: | | SXI: | | STRC: | | SAMB: | | SPRI: | | SCZ: | | SCX: | | SRW: | | STRF: | | SLE: | | SRN: | | SPAV: | | SLC: | | STRT: | | SCLF: | | SGS: | | STSI: | | SLS: | | SNR: | | SPLU: | | STRD: | | SNW: | | BFA: | | BRX: | | KSE: | | LMOI: | | BLIN: | | KFL: | | NDA: | | NAL: | | SEN: | | SVI: | | AMD: | | AMN: | | AMM: | | AMZ: | | AOI: | | AJA: | | AMQ: | | ALU: | | PDX: | | PSEA: | | PSEE: | | PSEQ: | | PECQ: | | PHH: | | KAL: | | KPHY: | | AHM: | | ACTI: | | ACAD: | | SAQ: | | SNA: | | MPRO: | | CEP: | | AVA: | | AWA: | | PBS: | | SLR: | | CPI: | | LFI: | | LFP: | | LEG: | | HSI: | | NMR: | | NIR: | | NKR: | |
» show all
 |
|---|
| Reference |
|
|---|
| Authors |
Bursy J, Pierik AJ, Pica N, Bremer E. |
|---|
| Title |
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase. |
|---|
| Journal |
J. Biol. Chem. 282 (2007) 31147-55. |
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Bursy J, Kuhlmann AU, Pittelkow M, Hartmann H, Jebbar M, Pierik AJ, Bremer E |
|---|
| Title |
Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses. |
|---|
| Journal |
Appl. Environ. Microbiol. 74 (2008) 7286-96. |
|---|
| Sequence |
|
|---|
| Reference |
|
|---|
| Authors |
Reuter K, Pittelkow M, Bursy J, Heine A, Craan T, Bremer E |
|---|
| Title |
Synthesis of 5-hydroxyectoine from ectoine: crystal structure of the non-heme iron(II) and 2-oxoglutarate-dependent dioxygenase EctD. |
|---|
| Journal |
PLoS. One. 5 (2010) e10647. |
|---|
| Sequence |
|
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
|---|
| LinkDB |
 |
|---|
