| Entry |
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| Name |
L-proline cis-4-hydroxylase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
L-proline,2-oxoglutarate:oxygen oxidoreductase (cis-4-hydroxylating)
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| Reaction(IUBMB) |
L-proline + 2-oxoglutarate + O2 = cis-4-hydroxy-L-proline + succinate + CO2 [RN: R11594]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Fe2+ and ascorbate. The enzyme, isolated from Rhizobium species, only produces cis-4-hydroxy-L-proline (cf. EC 1.14.11.57, L-proline trans-4-hydroxylase).
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| History |
EC 1.14.11.56 created 2017
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| Orthology |
| L-proline cis-4-hydroxylase |
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| Genes |
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| Reference |
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| Authors |
Hara R, Kino K |
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| Title |
Characterization of novel 2-oxoglutarate dependent dioxygenases converting L-proline to cis-4-hydroxy-l-proline. |
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| Journal |
Biochem. Biophys. Res. Commun. 379 (2009) 882-6. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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