| Entry |
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| Name |
thymine dioxygenase;
thymine 7-hydroxylase;
5-hydroxy-methyluracil dioxygenase;
5-hydroxymethyluracil oxygenase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)
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| Reaction(IUBMB) |
thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2 [RN: R01412]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires Fe2+ and ascorbate. Also acts on 5-hydroxymethyluracil to oxidize its -CH2OH group first to -CHO and then to -COOH.
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| History |
EC 1.14.11.6 created 1972, modified 1976 (EC 1.14.11.5 created 1972, incorporated 1976)
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| Reference |
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| Authors |
Bankel L, Holme E, Lindstedt G, Lindstedt S. |
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| Title |
Oxygenases involved in thymine and thymidine metabolism in Neurospora crassa. |
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| Journal |
FEBS. Lett. 21 (1972) 135-138. |
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| Reference |
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| Authors |
Liu CK, Hsu CA, Abbott MT. |
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| Title |
Catalysis of three sequential dioxygenase reactions by thymine 7-hydroxylase. |
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| Journal |
Arch. Biochem. Biophys. 159 (1973) 180-7. |
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| Reference |
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| Authors |
Warn-Cramer BJ, Macrander LA, Abbott MT. |
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| Title |
Markedly different ascorbate dependencies of the sequential alpha-ketoglutarate dioxygenase reactions catalyzed by an essentially homogeneous thymine 7-hydroxylase from Rhodotorula glutinis. |
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| Journal |
J. Biol. Chem. 258 (1983) 10551-7. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37256-67-0 |
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| LinkDB |
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