| Entry |
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| Name |
procollagen-proline 3-dioxygenase;
proline,2-oxoglutarate 3-dioxygenase;
prolyl 3-hydroxylase;
protocollagen proline 3-hydroxylase;
prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
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| Reaction(IUBMB) |
procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2 [RN: R03218]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
procollagen trans-3-hydroxy-L-proline [CPD: C04397];
succinate [CPD: C00042];
CO2 [CPD: C00011]
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| Comment |
Requires Fe2+ and ascorbate.
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| History |
EC 1.14.11.7 created 1981, modified 1983
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| Reference |
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| Authors |
Risteli J, Tryggvason K, Kivirikko KI. |
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| Title |
Prolyl 3-hydroxylase: partial characterization of the enzyme from rat kidney cortex. |
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| Journal |
Eur. J. Biochem. 73 (1977) 485-92. |
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| Reference |
|
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| Authors |
Risteli J, Tryggvason K, Kivirikko KI. |
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| Title |
A rapid assay for prolyl 3-hydroxylase activity. |
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| Journal |
Anal. Biochem. 84 (1978) 423-31. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 63551-75-7 |
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| LinkDB |
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