| Entry |
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| Name |
trimethyllysine dioxygenase;
trimethyllysine alpha-ketoglutarate dioxygenase;
TML-alpha-ketoglutarate dioxygenase;
TML hydroxylase;
6-N,6-N,6-N-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
N6,N6,N6-trimethyl-L-lysine,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
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| Reaction(IUBMB) |
N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 = 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2 [RN: R03451]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
3-hydroxy-N6,N6,N6-trimethyl-L-lysine [CPD: C01259];
succinate [CPD: C00042];
CO2 [CPD: C00011]
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| Comment |
Requires Fe2+ and ascorbate.
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| History |
EC 1.14.11.8 created 1983
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| Pathway |
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| Orthology |
| trimethyllysine dioxygenase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | CCAN: | | OCU: | | CFA: | | AML: | | UMR: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | BIU: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | BACU: | | LVE: | | ECB: | | HAI: | | RSS: | | PALE: | | LAV: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | CJO: | | APLA: | | TGU: | | GFR: | | FAB: | | PHI: | | CCW: | | FPG: | | FCH: | | CLV: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PBI: | | GJA: | | XLA: | | XTR: | | DRE: | | IPU: | | TRU: | | TNG: | | LCO: | | MZE: | | OLA: | | XMA: | | CSEM: | | SASA: | | LCM: | | CMK: | | BFO: | | SPU: | | SKO: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | MDE: | | AGA: | | AAG: | | CQU: | | BMOR: | | PXY: | | API: | | PHU: | | DPX: | | NAI: | | HRO: | | LGI: | | CRG: | | NVE: | | ADF: | | AQU: | | MIS: | | AGO: | | ERC: | | KLA: | | LTH: | | PPA: | | DHA: | | PIC: | | PGU: | | SPAA: | | LEL: | | CAL: | | CTP: | | COT: | | CDU: | | CTEN: | | YLI: | | CLU: | | CAUR: | | NCR: | | NTE: | | PAN: | | CTHR: | | MGR: | | TMN: | | FGR: | | FPU: | | FVR: | | FOX: | | NHE: | | TRE: | | MAW: | | MAJ: | | CMT: | | VAL: | | VDA: | | CFJ: | | ELA: | | SSL: | | BFU: | | MBE: | | PSCO: | | GLZ: | | AFM: | | AOR: | | ANG: | | AFV: | | ACT: | | NFI: | | PCS: | | PDP: | | CIM: | | CPW: | | PBL: | | PBN: | | ABE: | | TVE: | | AJE: | | PNO: | | PTE: | | BZE: | | BSC: | | BOR: | | ZTR: | | PFJ: | | BCOM: | | TML: | | CNE: | | CNB: | | CGI: | | TMS: | | TVS: | | DSQ: | | PCO: | | SHS: | | HIR: | | PSQ: | | ADL: | | FME: | | GTR: | | LBC: | | MPR: | | MRR: | | CCI: | | SCM: | | CPUT: | | WSE: | | WIC: | | UMA: | | PFP: | | PGR: | | MLR: | | SRE: | | ACAN: | | SMIN: | | FCY: | | PIF: | | PSOJ: | | SPAR: | | EHX: | | GTT: | | NGR: | | TSN: | |
» show all
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| Reference |
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| Authors |
Hulse JD, Ellis SR, Henderson LM. |
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| Title |
Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase. |
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| Journal |
J. Biol. Chem. 253 (1978) 1654-9. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 74622-49-4 |
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| LinkDB |
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