| Entry |
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| Name |
6-hydroxynicotinate 3-monooxygenase;
NicC;
6HNA monooxygenase;
HNA-3-monooxygenase
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
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| Sysname |
6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating)
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| Reaction(IUBMB) |
6-hydroxynicotinate + NADH + H+ + O2 = 2,5-dihydroxypyridine + NAD+ + H2O + CO2 [RN: R08764]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A flavoprotein (FAD) [1]. The reaction is involved in the aerobic catabolism of nicotinic acid.
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| History |
EC 1.14.13.114 created 2010
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| Pathway |
| Nicotinate and nicotinamide metabolism | | Microbial metabolism in diverse environments |
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| Orthology |
| 6-hydroxynicotinate 3-monooxygenase |
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| Genes |
SPE: | | SRR: | | SRL: | | SRY: | | SPLY: | | SRS: | | SRA: | | SMW: | | SMAR: | | SMAC: | | SLQ: | | SERF: | | PAO: | | TCI: | | PPU: | | PPF: | | PPG: | | PPW: | | PPB: | | PPI: | | PPX: | | PPUT: | | PPUN: | | PFS: | | PFW: | | PFB: | | PFF: | | PFX: | | PAZO: | | PSK: | | PFZ: | | PANR: | | HAM: | | ADI: | | MARS: | | RPJ: | | REU: | | REH: | | CNC: | | CTI: | | CBW: | | CGD: | | CCUP: | | BCN: | | BCH: | | BCM: | | BCJ: | | BCEN: | | BCEO: | | BMU: | | BMK: | | BMUL: | | BCED: | | BCEP: | | BCON: | | BSEM: | | BPSL: | | BMEC: | | BSTG: | | BGL: | | BGP: | | BGU: | | BGD: | | BGO: | | BUO: | | BPLA: | | BFN: | | BCAI: | | PSPU: | | PVE: | | PNR: | | BPE: | | BPC: | | BPER: | | BPEU: | | BPA: | | BBR: | | BBM: | | BBH: | | BBX: | | BPT: | | BAV: | | BFZ: | | AXO: | | AXN: | | AXS: | | AXX: | | ADT: | | AIS: | | AMIM: | | AFA: | | AAV: | | AAA: | | DAC: | | DEL: | | DTS: | | DHK: | | CTES: | | HSE: | | HSZ: | | MLN: | | RLG: | | RTR: | | BJU: | | BJP: | | HMC: | | RHZ: | | PSIN: | | PYE: | | PPHR: | | NRE: | | GOY: | | GAL: | | GXL: | | KEU: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | APK: | | ASV: | | ALI: | |
» show all
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| Reference |
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| Authors |
Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T. |
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| Title |
Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5. |
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| Journal |
Eur. J. Biochem. 260 (1999) 120-6. |
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| Reference |
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| Authors |
Jimenez JI, Canales A, Jimenez-Barbero J, Ginalski K, Rychlewski L, Garcia JL, Diaz E |
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| Title |
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440. |
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| Journal |
Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 11329-34. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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