KEGG   ENZYME: 1.14.17.4Help
Entry
EC 1.14.17.4                Enzyme                                 

Name
aminocyclopropanecarboxylate oxidase;
ACC oxidase;
ethylene-forming enzyme
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)
Reaction(IUBMB)
1-aminocyclopropane-1-carboxylate + ascorbate + O2 = ethylene + cyanide + dehydroascorbate + CO2 + 2 H2O [RN:R07214]
Reaction(KEGG)
Substrate
1-aminocyclopropane-1-carboxylate [CPD:C01234];
ascorbate [CPD:C00072];
O2 [CPD:C00007]
Product
ethylene [CPD:C06547];
cyanide [CPD:C00177];
dehydroascorbate [CPD:C05422];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A nonheme iron enzyme. Requires CO2 for activity. In the enzyme from plants, the ethylene has signalling functions such as stimulation of fruit-ripening.
History
EC 1.14.17.4 created 2003
Pathway
Cysteine and methionine metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K05933  
aminocyclopropanecarboxylate oxidase
Genes
RSS: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
BNA: 
THJ: 
CIT: 
CIC: 
TCC: 
18588418 18592410 18597239 18612358
GRA: 
105769639 105773340 105783020 105789924 105789942 105789967 105790536 105791688 105796114 105797149 105802573 105803453
GHI: 
107903979 107905674 107905676 107905899 107908352 107910369 107912629 107915412 107923209 107932273 107945007 107950208 107951489 107952114 107952577 107954048 107956389 107957214 107962059
EGR: 
104424713 104424714 104424715 104424716 104424717 104424718 104424719 104424720 104424721 104436497 104438309 104440284 104441437 104445669 104450538 104450539
GMX: 
100780155 100784455 100784459 100785514 100789627 100790622 100792063 100793294 100794816 100796909 100807427 100808025 100814810 100815336 100819184 100820256
PVU: 
PHAVU_002G304200g PHAVU_002G326600g PHAVU_003G082300g PHAVU_006G144900g PHAVU_007G135600g PHAVU_008G213800g PHAVU_008G214200g PHAVU_009G129500g
VRA: 
106762735 106763329 106765078 106765079 106765175 106766639 106766745 106769830
VAR: 
108322886 108323412(AB-ACO1) 108330808 108336202 108338025 108338027 108341045 108342451 108345036
CCAJ: 
109793755 109797540 109799389 109803578 109804404 109808078 109817071 109817981 109818885
MTR: 
MTR_2g025120 MTR_3g083370 MTR_3g088565 MTR_5g085330 MTR_6g092620
CAM: 
101490526 101495891 101500864(aco) 101505638 101514819
ADU: 
107460718 107466373 107482960 107490141 107496871 107496872 107496874
AIP: 
107606021 107606720 107608930 107608931 107609126 107609932 107636528 107638664 107644485
LJA: 
Lj0g3v0109219.1(Lj0g3v0109219.1) Lj0g3v0109219.2(Lj0g3v0109219.2) Lj1g3v0884400.1(Lj1g3v0884400.1) Lj2g3v0911850.1(Lj2g3v0911850.1) Lj2g3v0911860.1(Lj2g3v0911860.1) Lj2g3v2879460.1(Lj2g3v2879460.1) Lj4g3v0120430.1(Lj4g3v0120430.1) Lj6g3v1789900.1(Lj6g3v1789900.1)
LANG: 
109326282 109328346 109330191 109333359 109334607 109356783 109361097
FVE: 
101290700 101291370 101295098 101298627 101306888
PPER: 
18770210 18781368 18784056 18791775
PMUM: 
103319772 103324450 103329345 103340748
MDM: 
103400792 103404960 103411278 103411280 103434461(ACO) 103446762(ACO1) 103453365
PXB: 
103933106 103937366 103937371 103943975 103946813 103948231 103954990
ZJU: 
107414763 107417150 107421119 107423970
CSV: 
101203726 101204103(Cs-ACO2) 101209525(CS-ACO1) 101221460 101221653(CS-ACO2)
CMO: 
103484645(ACO3) 103487610 103491357(ACO1) 103496355 103498449
RCU: 
8260997 8265073 8267624 8270983
JCU: 
105637864 105638993 105640861 105640863 105649282
POP: 
POPTR_0002s07880g(POPTRDRAFT_643574) POPTR_0002s21750g(POPTRDRAFT_552732) POPTR_0004s00460g POPTR_0005s20530g(POPTRDRAFT_559288) POPTR_0006s15610g(POPTRDRAFT_762678) POPTR_0011s00970g(POPTRDRAFT_568162) POPTR_0014s15710g(POPTRDRAFT_573016)
VVI: 
100232928(ACO1) 100252394 100256784(ACO2) 100257676(ACO3)
SLY: 
100125909 101251255(ACO2) 101266529 543506(ACO4-like) 543800(aco5) 544052(ACO1) 544285(ACO4)
SPEN: 
107005451 107010265 107011760 107023167 107024027 107024035 107024353 107024662
SOT: 
102577542 102577821(ACO2) 102577917(ACO1) 102578788 102582504 102584001 102584835 102592023
INI: 
109158714 109159218(ACO1) 109164607 109167198(ACO3) 109169737 109171074 109186912
SIND: 
105155254 105159448 105161839 105162912 105162915 105162916 105162918 105162919 105162920 105162921 105162966 105168010 105173607 105175306 105180280
BVG: 
104884391 104893204 104900929 104902721
NNU: 
104586595 104594112 104600753 104605834 104606504 104606667
OSA: 
107278688 4324194(B1097D05.1) 4330873(OJ1353_F08.16-1) 4337818 4347224(OJ1163_C07.10) 4347225(ACO1) 4349970
DOSA: 
Os01t0580500-01(Os01g0580500) Os02t0771600-01(Os02g0771600) Os05t0149300-00(Os05g0149300) Os05t0149400-01(Os05g0149400) Os09t0451000-01(Os09g0451000) Os09t0451400-01(Os09g0451400) Os11t0186900-01(Os11g0186900)
OBR: 
102702762 102702913 102704086 102706500 102712857 102716840 102717708 102717987 102721801
BDI: 
100825510 100826347 100826865 100827208 100831517 100838946 100839084
ATS: 
F775_09413 F775_15958 F775_27311 F775_29309 F775_32857 F775_52717
SBI: 
8069498 8072801 8075978 8078636 8078948 8079305 8079762 8081032
ZMA: 
100191321 100273458 100280566 100283053 100382364(cl955_1) 103631299 103641390 103641391 103642621 103646970 109939280 542136(ACO31) 542137(acco20)
SITA: 
101756803 101766113 101766368 101766733 101780742 101780769 101781172 101781542
PDA: 
103701356 103702049 103709582 103713801 103713802 103713805 103713806 103717060 103718519 103718638 103718711 103719939
EGU: 
105032553 105035107 105038434 105038435 105039092 105040421 105047690 105047965 105051796 105061033
MUS: 
103968395 103972710 103974167 103974593 103974594 103974595 103974596 103974656 103984705 103986610 103987677 103992167 103994603
ATR: 
18428159 18434128 18436883
 » show all
Taxonomy
Reference
1  [PMID:7717997]
  Authors
Zhang Z, Schofield CJ, Baldwin JE, Thomas P, John P.
  Title
Expression, purification and characterization of 1-aminocyclopropane-1-carboxylate oxidase from tomato in Escherichia coli.
  Journal
Biochem. J. 307 ( Pt 1) (1995) 77-85.
Reference
2  [PMID:9398335]
  Authors
Zhang Z, Barlow JN, Baldwin JE, Schofield CJ.
  Title
Metal-catalyzed oxidation and mutagenesis studies on the iron(II) binding site of 1-aminocyclopropane-1-carboxylate oxidase.
  Journal
Biochemistry. 36 (1997) 15999-6007.
Reference
3
  Authors
Pirrung, M.C.
  Title
Ethylene biosynthesis from 1-aminocyclopropanecarboxylic acid.
  Journal
Acc. Chem. Res. 32 (1999) 711-718.
Reference
4  [PMID:11361015]
  Authors
Charng YY, Chou SJ, Jiaang WT, Chen ST, Yang SF.
  Title
The catalytic mechanism of 1-aminocyclopropane-1-carboxylic acid oxidase.
  Journal
Arch. Biochem. Biophys. 385 (2001) 179-85.
Reference
5  [PMID:11583172]
  Authors
Thrower JS, Blalock R 3rd, Klinman JP.
  Title
Steady-state kinetics of substrate binding and iron release in tomato ACC oxidase.
  Journal
Biochemistry. 40 (2001) 9717-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
98668-53-2
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