KEGG   ENZYME: 1.17.1.2Help
Entry
EC 1.17.1.2                 Enzyme                                 
Name 4-hydroxy-3-methylbut-2-enyl diphosphate reductase;
isopentenyl-diphosphate:NADP+ oxidoreductase;
LytB;
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase;
HMBPP reductase;
IspH;
LytB/IspH
Class Oxidoreductases;
Acting on CH or CH2 groups;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname isopentenyl-diphosphate:NAD(P)+ oxidoreductase
Reaction(IUBMB) (1) isopentenyl diphosphate + NAD(P)+ + H2O =
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
[RN:R05884 R08209];
(2) dimethylallyl diphosphate + NAD(P)+ + H2O =
(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
[RN:R07219 R08210]
Reaction(KEGG) R05884 R07219 R08209 R08210
Show
Substrate isopentenyl diphosphate [CPD:C00129];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
dimethylallyl diphosphate [CPD:C00235]
Product (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate [CPD:C11811];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment An iron-sulfur protein that contains either a [3Fe-4S] [6] or a
[4Fe-4S] [5] cluster. This enzyme comprises a system in which
ferredoxin is first reduced and subsequently reoxidized by an
NAD(P)+-dependent reductase. This is the last enzyme in the
non-mevalonate pathway for isoprenoid biosynthesis. This pathway,
also known as the 1-deoxy-D-xylulose 5-phosphate (DOXP) or as the
2-C-methyl-D-erythritol-4-phosphate (MEP) pathway, is found in most
bacteria and in plant chloroplasts. The enzyme acts in the reverse
direction, producing a 5:1 mixture of isopentenyl diphosphate and
dimethylallyl diphosphate.
Pathway ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology K03527  4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Genes ATH: AT4G34350(HDR)
POP: POPTR_557296
RCU: RCOM_0938310
VVI: 100267479
OSA: 4334003(Os03g0731900)
SBI: SORBI_01g009140
ZMA: 100383164(HDR)
PPP: PHYPADRAFT_194018 PHYPADRAFT_206243
CRE: CHLREDRAFT_59822(IDS1)
OLU: OSTLU_32979(IDS)
CME: CMJ152C
PFA: PFA_0225w(lytB)
PFD: PFDG_01560
PFH: PFHG_00328
PYO: PY01243
PCB: PC000598.01.0
PBE: PB000173.01.0
PKN: PKH_020880
PVX: PVX_081535
TAN: TA17670
TPV: TP03_0674
BBO: BBOV_III001660(17.m07167)
TGO: TGME49_027420
PTI: PHATRDRAFT_50808(HDR)
TPS: THAPSDRAFT_270376
ECO: b0029(ispH)
ECJ: JW0027(ispH)
ECD: ECDH10B_0030(ispH)
EBW: BWG_0027(ispH)
ECE: Z0034(ispH)
ECS: ECs0032(ispH)
ECF: ECH74115_0031(ispH)
ETW: ECSP_0030(ispH)
EOJ: ECO26_0029(ispH)
EOI: ECO111_0029(ispH)
EOH: ECO103_0030(ispH)
ECG: E2348C_0029(ispH)
EOK: G2583_0030(ispH)
ECC: c0033(ispH)
ECP: ECP_0027
ECI: UTI89_C0031(ispH)
ECV: APECO1_1954(ispH)
ECX: EcHS_A0031(ispH)
ECW: EcE24377A_0029(ispH)
ECM: EcSMS35_0027(ispH)
ECY: ECSE_0027(ispH)
ECR: ECIAI1_0030(ispH)
ECQ: ECED1_0026(ispH)
ECK: EC55989_0028(ispH)
ECT: ECIAI39_0030(ispH)
EUM: ECUMN_0030(ispH)
ECZ: ECS88_0028(ispH)
ECL: EcolC_3626(ispH)
EBR: ECB_00033(ispH)
EBD: ECBD_3587(ispH)
EFE: EFER_0022(ispH)
STY: STY0058(ispH)
STT: t0051(ispH)
STM: STM0049(ispH)
SPT: SPA0050(ispH)
SEK: SSPA0046(ispH)
SPQ: SPAB_00059(ispH)
SEI: SPC_0052(ispH)
SEC: SC0043(ispH)
SEH: SeHA_C0053(ispH)
SEE: SNSL254_A0053(ispH)
SEW: SeSA_A0054(ispH)
SEA: SeAg_B0055(ispH)
SED: SeD_A0053(ispH)
SEG: SG0052(ispH)
SET: SEN0049(ispH)
SES: SARI_02945(ispH)
YPE: YPO0477(ispH)
YPK: y3697(ispH)
YPA: YPA_4071(ispH)
YPN: YPN_0350
YPM: YP_3702(ispH)
YPP: YPDSF_3154(ispH)
YPG: YpAngola_A0787(ispH)
YPZ: YPZ3_0464(lytB)
YPS: YPTB0620(ispH)
YPI: YpsIP31758_3457(ispH)
YPY: YPK_3585(ispH)
YPB: YPTS_0644(ispH)
YEN: YE0619(ispH)
SFL: SF0026(ispH)
SFX: S0028(ispH)
SFV: SFV_0023(ispH)
SSN: SSON_0034(ispH)
SBO: SBO_0028(ispH)
SBC: SbBS512_E0033(ispH)
SDY: SDY_0051(ispH)
ECA: ECA3873(ispH)
PCT: PC1_3650(ispH)
PWA: Pecwa_3843(ispH)
ETA: ETA_07150(ispH)
EPY: EpC_07030(ispH)
EAM: EAMY_2934(ispH)
EAY: EAM_0658(ispH)
EBI: EbC_06770(ispH)
PLU: plu0594(ispH)
PAY: PAU_00559(ispH)
BUC: BU147(ispH)
BAS: BUsg140(ispH)
BAB: bbp137(lytB)
BAP: BUAP5A_145(ispH)
BAU: BUAPTUC7_146(ispH)
WBR: WGLp292(lytB)
SGL: SG0417(ispH)
ENT: Ent638_0587(ispH)
ENC: ECL_00837
ESA: ESA_03309(ispH)
CTU: Ctu_06550(ispH)
KPN: KPN_00024(ispH)
KPE: KPK_4732(ispH)
KPU: KP1_0845(ispH)
KVA: Kvar_4371
CKO: CKO_03363(ispH)
CRO: ROD_00261(ispH)
SPE: Spro_0701(ispH)
PMR: PMI0018(ispH)
EIC: NT01EI_0682
ETR: ETAE_0585(ispH)
BPN: BPEN_124(ispH)
HDE: HDEF_0834(ispH)
DDA: Dd703_0590
DDC: Dd586_3585
DZE: Dd1591_0551
XBO: XBJ1_1723(ispH)
XNE: XNC1_3790(ispH)
PAM: PANA_0672(ispH)
RIP: RIEPE_0555(ispH)
HIN: HI1007(ispH)
HIT: NTHI1182(ispH)
HIP: CGSHiEE_06935(ispH)
HIQ: CGSHiGG_08635(ispH)
HDU: HD0064(ispH)
HAP: HAPS_1306(ispH)
HSO: HS_0184(ispH)
HSM: HSM_0050(ispH)
PMU: PM1664(ispH)
MSU: MS1749(ispH)
APL: APL_1520(ispH)
APJ: APJL_1546(ispH)
APA: APP7_1580(ispH)
ASU: Asuc_1874(ispH)
AAP: NT05HA_2348(ispH)
AAT: D11S_1928(ispH)
XFA: XF2416(ispH)
XFT: PD1435
XFM: Xfasm12_1576(ispH)
XFN: XfasM23_1519(ispH)
XCC: XCC1157(ispH)
XCB: XC_3085(ispH)
XCA: xccb100_3181(ispH)
XCV: XCV1292(ispH)
XAC: XAC1256(ispH)
XOO: XOO1628(ispH)
XOM: XOO_1514(ispH)
XOP: PXO_05537(ispH)
XAL: XALc_0924(ispH)
SML: Smlt1342(ispH)
SMT: Smal_1127(ispH)
VCH: VC0685(ispH)
VCO: VC0395_A0217(ispH)
VCM: VCM66_0643(ispH)
VCJ: VCD_003635(ispH)
VVU: VV1_0504(ispH)
VVY: VV0690(ispH)
VPA: VP0537(ispH)
VHA: VIBHAR_00983(ispH)
VSP: VS_0539(ispH)
VEX: VEA_004416
VFI: VF_0470(ispH)
VFM: VFMJ11_0469(ispH)
VSA: VSAL_I0583(ispH)
PPR: PBPRA0594(ispH)
PAE: PA4557(ispH)
PAU: PA14_60330(ispH)
PAP: PSPA7_3192(ispH2) PSPA7_5197(ispH)
PAG: PLES_49401(ispH)
PPU: PP_0606(ispH)
PPF: Pput_0647(ispH)
PPG: PputGB1_0652(ispH)
PPW: PputW619_4556(ispH)
PST: PSPTO_0809(ispH)
PSB: Psyr_0713(ispH)
PSP: PSPPH_0724(ispH)
PFL: PFL_5318(ispH)
PFO: Pfl01_4849(ispH)
PFS: PFLU0771(ispH)
PEN: PSEEN4689(ispH)
PMY: Pmen_0956
PSA: PST_0967(ispH)
CJA: CJA_3214(ispH)
AVN: Avin_11810(ispH)
PAR: Psyc_1722(ispH)
PCR: Pcryo_2002(ispH)
PRW: PsycPRwf_0578(ispH)
ACI: ACIAD3322(ispH)
ACD: AOLE_01595(ispH)
ACB: A1S_3169
ABM: ABSDF0323(ispH)
ABY: ABAYE0313(ispH)
ABC: ACICU_03371(ispH)
ABN: AB57_3626(ispH)
ABB: ABBFA_000341(ispH)
MCT: MCR_0354(ispH)
SON: SO_3529(ispH)
SDN: Sden_2720(ispH)
SFR: Sfri_2887(ispH)
SAZ: Sama_0927(ispH)
SBL: Sbal_1057(ispH)
SBM: Shew185_1124(ispH)
SBN: Sbal195_1159(ispH)
SBP: Sbal223_3232(ispH)
SLO: Shew_1102(ispH)
SPC: Sputcn32_1062(ispH)
SSE: Ssed_1197(ispH)
SPL: Spea_1086(ispH)
SHE: Shewmr4_2954(ispH)
SHM: Shewmr7_3036(ispH)
SHN: Shewana3_3133(ispH)
SHW: Sputw3181_3103(ispH)
SHL: Shal_1134(ispH)
SWD: Swoo_1294(ispH)
SWP: swp_3724(ispH)
SVO: SVI_1005(ispH)
ILO: IL1125(lytB)
CPS: CPS_1211(ispH)
PHA: PSHAa0921(ispH)
PAT: Patl_3175(ispH)
SDE: Sde_2563
MAQ: Maqu_0865(ispH)
AMC: MADE_03027(ispH)
PIN: Ping_3268
MCA: MCA1815(ispH)
FTU: FTT_0833(ispH)
FTF: FTF0833(ispH)
FTW: FTW_1353(ispH)
FTL: FTL_0327(ispH)
FTH: FTH_0325(ispH)
FTA: FTA_0348(ispH)
FTM: FTM_0425(ispH)
FPH: Fphi_0475(ispH)
NOC: Noc_1744
NHL: Nhal_1240
NWA: Nwat_1372
ALV: Alvin_1596
AEH: Mlg_0854
HHA: Hhal_1834
TGR: Tgr7_3219
TKM: TK90_2553
HNA: Hneap_2229
HCH: HCH_05930(ispH)
CSA: Csal_0484
ABO: ABO_0462(lytB)
MMW: Mmwyl1_4227
AHA: AHA_0685(ispH)
ASA: ASA_0687(ispH)
TAU: Tola_2952
AFE: Lferr_2858
AFR: AFE_3258(ispH)
BCI: BCI_0558(ispH)
RMA: Rmag_1023(ispH)
VOK: COSY_0924(ispH)
KKO: Kkor_1661
GPB: HDN1F_03270(ispH)
NMA: NMA0624(ispH)
NME: NMB1831(ispH)
NMC: NMC0385(ispH)
NMN: NMCC_0391(ispH)
NMI: NMO_0330(ispH)
NGO: NGO0072(ispH)
NGK: NGK_0106(ispH)
CVI: CV_3567(ispH)
LHK: LHK_00616(ispH)
RSO: RSc2442(ispH)
RSC: RCFBP_10984(ispH)
RSL: RPSI07_1032(ispH)
RPI: Rpic_2710(ispH)
RPF: Rpic12D_2320(ispH)
REU: Reut_A2730(ispH) Reut_B4898(ispH)
REH: H16_A3031(ispH) H16_B2169(ispH)
RME: Rmet_2868(ispH) Rmet_4169(ispH)
CTI: RALTA_A2505(ispH) RALTA_B1952(ispH)
BMA: BMA2228(ispH) BMAA1962(ispH)
BMV: BMASAVP1_0980(ispH) BMASAVP1_A2644(ispH)
BML: BMA10229_1267 BMA10229_A1018
BMN: BMA10247_2097(ispH) BMA10247_A2242(ispH)
BPS: BPSL0919(ispH) BPSS2168(ispH)
BPM: BURPS1710b_1141(ispH) BURPS1710b_A1285(ispH)
BPL: BURPS1106A_0986(ispH) BURPS1106A_A2929(ispH)
BPD: BURPS668_0981(ispH) BURPS668_A3054(ispH)
BPR: GBP346_A0910(ispH)
BTE: BTH_I0783(ispH) BTH_II2243(ispH)
BVI: Bcep1808_2577 Bcep1808_3716
BUR: Bcep18194_A5831(ispH) Bcep18194_B0106(ispH)
BCN: Bcen_1888(ispH) Bcen_5308(ispH)
BCH: Bcen2424_2499 Bcen2424_5552
BCM: Bcenmc03_2524(ispH) Bcenmc03_4720(ispH)
BCJ: BCAL2710(ispH) BCAM2738(ispH)
BAM: Bamb_2546(ispH) Bamb_4876(ispH)
BAC: BamMC406_2417(ispH) BamMC406_5423(ispH)
BMU: Bmul_0795 Bmul_3253(ispH)
BMJ: BMULJ_02464(ispH) BMULJ_05272(ispH)
BXE: Bxe_A0820(ispH) Bxe_B0018(ispH)
BPH: Bphy_0587(ispH) Bphy_4130(ispH)
BPY: Bphyt_3146(ispH) Bphyt_7036(ispH)
BGL: bglu_1g28650(ispH) bglu_2g22170(ispH)
BGE: BC1002_2388 BC1002_5076
PNU: Pnuc_1731
PNE: Pnec_1449
BPE: BP1237(ispH)
BPA: BPP1852(ispH)
BBR: BB3256(ispH)
BPT: Bpet3147(ispH)
BAV: BAV2403(ispH)
RFR: Rfer_3248(ispH)
POL: Bpro_0951(ispH)
PNA: Pnap_3337(ispH)
AAV: Aave_3771(ispH)
AJS: Ajs_3448(ispH)
DIA: Dtpsy_2775(ispH)
VEI: Veis_1652(ispH)
DAC: Daci_1906(ispH)
VAP: Vapar_4031(ispH)
CTT: CtCNB1_3819
MPT: Mpe_A2693(ispH)
HAR: HEAR2466(ispH)
MMS: mma_2549(ispH)
HSE: Hsero_1186(lytB)
LCH: Lcho_0693(ispH)
TIN: Tint_1647
NEU: NE0649(ispH)
NET: Neut_1903(ispH)
NMU: Nmul_A0089(ispH)
EBA: ebA4444(ispH)
AZO: azo1202(ispH)
DAR: Daro_3043
TMZ: Tmz1t_1778(ispH)
TBD: Tbd_1860
MFA: Mfla_2431
MMB: Mmol_2279
MEH: M301_2625
MEI: Msip34_2604
APP: CAP2UW1_2543
SLT: Slit_2088
GCA: Galf_2056
HPY: HP0400(ispH)
HPJ: jhp0981(ispH)
HPA: HPAG1_0992(ispH)
HPS: HPSH_05405(ispH)
HPG: HPG27_997(ispH)
HPP: HPP12_1020(ispH)
HPB: HELPY_1025(ispH)
HPL: HPB8_451(ispH)
HHE: HH0138(ispH)
HAC: Hac_0458(ispH)
HMS: HMU00570(lytB)
WSU: WS1310(ispH)
TDN: Suden_0872(ispH)
CJE: Cj0894c(ispH)
CJR: CJE0973(ispH)
CJJ: CJJ81176_0903(ispH)
CJU: C8J_0831(ispH)
CJD: JJD26997_0919(ispH)
CFF: CFF8240_1251(ispH)
CCV: CCV52592_0515(ispH)
CHA: CHAB381_0483(ispH)
CCO: CCC13826_1566(ispH)
CLA: Cla_1191(ispH)
ABU: Abu_2050(ispH)
ANT: Arnit_0489
SDL: Sdel_0612
NIS: NIS_0662(ispH)
SUN: SUN_0548(ispH)
NAM: NAMH_0910(ispH)
GSU: GSU2604(lytB)
GME: Gmet_0866
GUR: Gura_1466
GLO: Glov_2146
GBM: Gbem_3256
GEO: Geob_2363
GEM: GM21_0994
PCA: Pcar_1883(lytB)
PPD: Ppro_1349
DVU: DVU0055(ispH)
DVL: Dvul_2906
DVM: DvMF_2020
DDE: Dde_0390
DDS: Ddes_2083
DMA: DMR_26630(ispH)
DSA: Desal_2767
LIP: LI0728(lytB)
DBA: Dbac_3462
DRT: Dret_1078
DPS: DP2166
DAK: DaAHT2_1060
DOL: Dole_0383
DAL: Dalk_3710
DAT: HRM2_31890(ispH)
ADE: Adeh_1519
ACP: A2cp1_2436
AFW: Anae109_2302
ANK: AnaeK_2348
SAT: SYN_02454
SFU: Sfum_1812
DBR: Deba_1165
WOL: WD1274(ispH)
WBM: Wbm0046(ispH)
WRI: WRi_012440(ispH)
WPI: WPa_0811(ispH)
AMA: AM804(ispH)
AMF: AMF_597(ispH)
ACN: ACIS_00535(ispH)
APH: APH_0380(ispH)
ERU: Erum5180(ispH)
ERW: ERWE_CDS_05430(ispH)
ERG: ERGA_CDS_05330(ispH)
ECN: Ecaj_0526(ispH)
ECH: ECH_0502(ispH)
NSE: NSE_0438(ispH)
NRI: NRI_0412(ispH)
PUB: SAR11_0124(lytB)
MLO: mlr7502(ispH)
MES: Meso_0748(ispH)
PLA: Plav_0686
SME: SMc00016(ispH)
SMD: Smed_0527(ispH)
ATU: Atu0774(ispH)
ARA: Arad_1244(ispH)
AVI: Avi_1052(ispH)
RET: RHE_CH00961(ispH)
REC: RHECIAT_CH0001056(ispH)
RLE: RL1030(ispH)
RLT: Rleg2_0611(ispH)
RLG: Rleg_0651(ispH)
RHI: NGR_c05330(ispH)
BME: BMEI1459(ispH)
BMI: BMEA_A0511(ispH)
BMF: BAB1_0501(ispH)
BMB: BruAb1_0497(ispH)
BMC: BAbS19_I04640(ispH)
BMS: BR0475(ispH)
BMT: BSUIS_A0502(ispH)
BOV: BOV_0480(ispH)
BCS: BCAN_A0482(ispH)
BMR: BMI_I477(ispH)
OAN: Oant_0589(ispH)
BJA: bll3007(ispH) blr1314(ispH)
BRA: BRADO2632(ispH) BRADO6588(ispH)
BBT: BBta_0948(ispH) BBta_2972(ispH)
RPA: RPA3734(ispH) RPA4271(ispH)
RPB: RPB_1340(ispH) RPB_1729(ispH)
RPC: RPC_1726(ispH) RPC_4078(ispH)
RPD: RPD_3570(ispH) RPD_4030(ispH)
RPE: RPE_1816(ispH) RPE_4130(ispH)
RPT: Rpal_4255(ispH) Rpal_4751(ispH)
NWI: Nwi_2266(ispH) Nwi_2689(ispH)
NHA: Nham_2679(ispH) Nham_3745(ispH)
OCA: OCAR_6667(ispH) OCAR_7331(ispH)
BHE: BH04410(ispH)
BQU: BQ03600(ispH)
BBK: BARBAKC583_0406(ispH)
BTR: Btr_0655(ispH)
BGR: Bgr_04730(ispH)
XAU: Xaut_2355(ispH)
AZC: AZC_1468
SNO: Snov_3086
MEX: Mext_2593(ispH)
MEA: Mex_1p2713(ispH)
MDI: METDI3326(ispH)
MRD: Mrad2831_4312(ispH)
MET: M446_6025(ispH)
MPO: Mpop_2621(ispH)
MCH: Mchl_2816(ispH)
MNO: Mnod_7157 Mnod_7260(ispH)
BID: Bind_1904(ispH)
MSL: Msil_3225(ispH)
CCR: CC_3361
CCS: CCNA_03471
CAK: Caul_4391
CSE: Cseg_0331
PZU: PHZ_c2893
BSB: Bresu_2726
SIL: SPO3207(ispH)
SIT: TM1040_2569(ispH)
RSP: RSP_1666(ispH)
RSH: Rsph17029_0299(ispH)
RSQ: Rsph17025_2580(ispH)
RSK: RSKD131_3066(ispH)
RCP: RCAP_rcc03423(ispH)
JAN: Jann_0507(ispH)
RDE: RD1_1355(ispH)
PDE: Pden_3619(ispH)
DSH: Dshi_0188(ispH)
MMR: Mmar10_2215
HNE: HNE_2713(ispH)
HBA: Hbal_1046
ZMO: ZMO0875(ispH)
ZMN: Za10_0417(ispH)
NAR: Saro_1087
SAL: Sala_1136
SWI: Swit_2692
SJP: SJA_C1-28170(lytB)
ELI: ELI_01560
GOX: GOX0179
GBE: GbCGDNIH1_1875
ACR: Acry_1832
GDI: GDI_3102(ispH)
GDJ: Gdia_3265
APT: APA01_19770(lytB)
RRU: Rru_A0059
RCE: RC1_3654(ispH)
MAG: amb0764
AZL: AZL_015900(ispH)
PBR: PB2503_02232
APB: SAR116_1106
MGM: Mmc1_3428
BSU: BSU25160(ispH)
BHA: BH1382(ispH)
BAN: BA_4511(ispH)
BAR: GBAA_4511(ispH)
BAT: BAS4190(ispH)
BAH: BAMEG_4550(ispH)
BAI: BAA_4532(ispH)
BAL: BACI_c42580(lytB)
BCA: BCE_4368(ispH)
BCZ: BCZK4038(ispH)
BCR: BCAH187_A4422(ispH)
BCB: BCB4264_A4405(ispH)
BCU: BCAH820_4310(ispH)
BCG: BCG9842_B0831(ispH)
BCQ: BCQ_4075(ispH)
BCX: BCA_4399(ispH)
BCY: Bcer98_3015(ispH)
BTK: BT9727_4028(ispH)
BTL: BALH_3881(ispH)
BTB: BMB171_C3953
BWE: BcerKBAB4_4140(ispH)
BLI: BL03721(ispH)
BLD: BLi02695(ispH)
BCL: ABC1694(ispH)
BAY: RBAM_023470(ispH)
BPU: BPUM_2249(ispH)
BPF: BpOF4_13755(ispH)
BMQ: BMQ_4537(ispH)
BMD: BMD_4523(ispH)
BSE: Bsel_2340
GKA: GK2477(ispH)
GTN: GTNG_2414(ispH)
GWC: GWCH70_2409(ispH)
GYM: GYMC10_5090(ispH)
GYC: GYMC61_0162(ispH)
GCT: GC56T3_1013
AFL: Aflv_0861(ispH)
LMO: lmo1451(ispH)
LMF: LMOf2365_1470(ispH)
LMC: Lm4b_01461(ispH)
LMN: LM5578_1593(ispH)
LMY: LM5923_1545(ispH)
LSP: Bsph_3685(ispH)
ESI: Exig_0836(ispH)
EAT: EAT1b_0585(ispH)
MCL: MCCL_1209(ispH)
BBE: BBR47_49230(ispH)
PJD: Pjdr2_4780(ispH)
AAC: Aaci_0997(ispH)
BTS: Btus_0455
CAC: CA_C1847(lytB)
CPE: CPE1085(lytB)
CPF: CPF_1341(ispH)
CPR: CPR_1152(ispH)
CTC: CTC01314(lytB)
CNO: NT01CX_2096
CTH: Cthe_0714
CDF: CD1818(ispH)
CDC: CD196_1738(ispH)
CDL: CDR20291_1713(ispH)
CKL: CKL_1567
CKR: CKR_1457
CCB: Clocel_2138
AMT: Amet_2625
AOE: Clos_1562
STH: STH910(ispH)
SWO: Swol_1344
DSY: DSY2255
DHD: Dhaf_3385
DRM: Dred_1154
DAE: Dtox_2102
PTH: PTH_1619
DAU: Daud_1178
HMO: HM1_1931(ispH)
FMA: FMG_0826
EEL: EUBELI_00929
ERE: EUBREC_1637
BPB: bpr_I2036(ispH)
TTE: TTE1352(lytB)
TEX: Teth514_1606
TPD: Teth39_1169
TIT: Thit_1147
TMT: Tmath_1200
CHY: CHY_1925(lytB)
MTA: Moth_1329
CSC: Csac_1891
TTM: Tthe_1362
CPO: COPRO5265_0797
MPE: MYPE1330
MTU: Rv1110(ispH) Rv3382c(lytB1)
MTC: MT1141(ispH) MT3490(lytB-2)
MRA: MRA_1121(ispH) MRA_3422(lytB1)
MTF: TBFG_11132(ispH) TBFG_13416
MTB: TBMG_02873(ispH) TBMG_03431(TBMG_03431.1)
MBO: Mb1140(ispH) Mb3414c(lytB1)
MBB: BCG_1170(ispH) BCG_3451c(lytB1)
MBT: JTY_1143(ispH) JTY_3451(lytB1)
MLE: ML1938(ispH)
MLB: MLBr_01938(ispH)
MPA: MAP2684c(ispH)
MAV: MAV_1230(ispH)
MSM: MSMEG_5224(ispH)
MUL: MUL_0168(ispH)
MVA: Mvan_4631
MGI: Mflv_2079(ispH)
MAB: MAB_1257(ispH)
MMC: Mmcs_4105(ispH)
MKM: Mkms_4181(ispH)
MJL: Mjls_4336(ispH)
MMI: MMAR_0277(lytB2) MMAR_4355(ispH)
CGL: NCgl0982(ispH)
CGB: cg1164(ispH)
CGT: cgR_1109(ispH)
CEF: CE1079(ispH)
CDI: DIP0943(ispH)
CJK: jk1449(ispH)
CUR: cur_0618(ispH)
CAR: cauri_0943(ispH)
CPU: cpfrc_00742(ispH)
NFA: nfa47950(ispH)
RHA: RHA1_ro05870(ispH)
RER: RER_42340(ispH)
ROP: ROP_59320(ispH)
GBR: Gbro_1680
TPR: Tpau_3114
SRT: Srot_1090
SCO: SCO5058(ispH)
SMA: SAV_3210(ispH)
SGR: SGR_2472(ispH)
SCB: SCAB_33471(ispH)
TWH: TWT642(ispH)
TWS: TW664(ispH)
LXX: Lxx16760(ispH)
CMI: CMM_2228(ispH)
CMS: CMS_2415(ispH)
ART: Arth_2833(ispH)
ACH: Achl_2548(ispH)
RSA: RSal33209_1156(ispH)
KRH: KRH_07120(ispH)
MLU: Mlut_16300(ispH)
RMU: RMDY18_05660
BCV: Bcav_1102(ispH)
BFA: Bfae_22960(ispH)
JDE: Jden_0747(ispH)
KSE: Ksed_20400(ispH)
XCE: Xcel_0941
SKE: Sked_26420
CFL: Cfla_0969
PAC: PPA0572(ispH)
PAK: HMPREF0675_3632(ispH)
PFR: PFREUD_16970(ispH)
NCA: Noca_1075
KFL: Kfla_4244 Kfla_5577
TFU: Tfu_0471(ispH)
NDA: Ndas_0119
TCU: Tcur_1091
SRO: Sros_3713 Sros_8480
FRA: Francci3_0824 Francci3_3881(ispH)
FRE: Franean1_0845(ispH) Franean1_5712
FAL: FRAAL1433(ispH) FRAAL6150(ispH)
ACE: Acel_1858
NML: Namu_4387(ispH)
GOB: Gobs_1008
KRA: Krad_1123(ispH)
SEN: SACE_0939(ispH) SACE_4326(ispH)
SVI: Svir_31480(ispH)
TBI: Tbis_3065
AMD: AMED_8054(lytB)
AMI: Amir_0729(ispH) Amir_5019
STP: Strop_0879(ispH)
SAQ: Sare_0824(ispH)
MAU: Micau_0875
CAI: Caci_8273(ispH)
SNA: Snas_1996 Snas_5538
AHE: Arch_1499
MCU: HMPREF0573_10790(ispH)
BLO: BL1361(ispH)
BLJ: BLD_0227(ispH)
BLN: Blon_0898(ispH)
BLL: BLJ_1254(ispH)
BAD: BAD_1081(ispH)
BLA: BLA_0742(ispH)
BLC: Balac_1164(ispH)
BLT: Balat_1164(ispH)
BDE: BDP_1517(ispH)
RXY: Rxyl_2212
CWO: Cwoe_1837
AFO: Afer_1349
CCU: Ccur_06870
SHI: Shel_09680
APV: Apar_0726
ELE: Elen_1335
OLS: Olsu_0917
CTR: CT859(ispH)
CTA: CTA_0937(ispH)
CTB: CTL0234(ispH)
CTL: CTLon_0234(ispH)
CTJ: JALI_8701(ispH)
CMU: TC0249(ispH)
CPN: CPn1017(ispH)
CPA: CP0836(ispH)
CPJ: CPj1017(ispH)
CPT: CpB1055(ispH)
CCA: CCA00744(ispH)
CAB: CAB711(ispH)
CFE: CF0272(ispH)
PCU: pc1078(ispH)
TPA: TP0547
TPP: TPASS_0547(lytB)
TDE: TDE1096(ispH)
SSM: Spirs_3235
LIL: LA_2420(lytB)
LIC: LIC11529(lytB)
LBJ: LBJ_1807(lytB)
LBL: LBL_1476(lytB)
LBI: LEPBI_I1588(ispH)
LBF: LBF_1537(lytB)
BHY: BHWA1_01221
BRM: Bmur_0822
BPO: BP951000_0270
ABA: Acid345_1739
ACA: ACP_3328(ispH)
SUS: Acid_1259
BTH: BT_2061(ispH)
BFR: BF3748(ispH)
BFS: BF3536(ispH)
BVU: BVU_1936
PGI: PG0604(ispH)
PGN: PGN_0647(ispH)
PDI: BDI_3740(ispH)
APS: CFPG_127(ispH)
PRU: PRU_0161(ispH)
PMZ: HMPREF0659_A6545(ispH)
SRU: SRU_1880(ispH)
SRM: SRM_02088(ispH)
RMR: Rmar_0711
CHU: CHU_0087(ispH)
DFE: Dfer_3543
SLI: Slin_5344
CPI: Cpin_6621
PHE: Phep_3618(ispH)
FSU: Fisuc_1940
FNU: FN1781
STR: Sterm_4093
OTE: Oter_3652
CAA: Caka_2086
MIN: Minf_2119(lytB)
AMU: Amuc_1646
GAU: GAU_2758(ispH)
RBA: RB9288(lytB)
PSL: Psta_0598
PLM: Plim_3455
EMI: Emin_0409
RSD: TGRD_661
TAI: Taci_1028
ACO: Amico_1024
SYN: slr0348
SYW: SYNW0252(lytB)
SYC: syc1431_d(lytB)
SYF: Synpcc7942_0073
SYD: Syncc9605_0246
SYE: Syncc9902_0275
SYG: sync_0292(ispH)
SYR: SynRCC307_2319(lytB)
SYX: SynWH7803_0296(lytB)
SYP: SYNPCC7002_A0517(ispH)
CYA: CYA_1148(ispH)
CYB: CYB_2643(ispH)
TEL: tlr1041
MAR: MAE_16190
CYT: cce_1108
CYP: PCC8801_2610
CYC: PCC7424_4926
CYN: Cyan7425_2354
CYH: Cyan8802_3496
CYU: UCYN_05960
GVI: glr3299
ANA: all0985
NPU: Npun_R3286
AVA: Ava_2949
NAZ: Aazo_1257
PMA: Pro0296(lytB)
PMM: PMM0264(lytB)
PMT: PMT1854(lytB)
PMN: PMN2A_1630
PMI: PMT9312_0266
PMB: A9601_02861(lytB)
PMC: P9515_02971(lytB)
PMF: P9303_24821(lytB)
PMG: P9301_02871(lytB)
PMH: P9215_02881(lytB)
PMJ: P9211_02911(lytB)
PME: NATL1_03421(lytB)
TER: Tery_4479
AMR: AM1_4950(ispH)
CTE: CT0283(ispH)
CPC: Cpar_1751(ispH)
CCH: Cag_0579(ispH)
CPH: Cpha266_0414(ispH)
CPB: Cphamn1_0456(ispH)
CLI: Clim_0345(ispH)
PVI: Cvib_1518(ispH)
PLT: Plut_1736(ispH)
PPH: Ppha_0448(ispH)
PAA: Paes_0419(ispH)
CTS: Ctha_0114(ispH)
DET: DET1344(ispH)
DEH: cbdb_A1294(ispH)
DEB: DehaBAV1_1155
DEV: DhcVS_1126(ispH)
DEG: DehalGT_1080
TRO: trd_1164(ispH) trd_1662(ispH)
STI: Sthe_0330
DRA: DR_2164
DGE: Dgeo_1010
DDR: Deide_10440
TRA: Trad_1220
TTH: TTC1983(lytB)
TTJ: TTHA0015
MRB: Mrub_2085
MSV: Mesil_1040
AAE: aq_1739(lytB)
HYA: HY04AAS1_1048
HTH: HTH_1237(lytB)
TAL: Thal_0312
SUL: SYO3AOP1_1148
SAF: SULAZ_0297(ispH)
PMX: PERMA_0082(ispH)
TMA: TM1444
TPT: Tpet_1350
TLE: Tlet_1650
TRQ: TRQ2_1336
TNA: CTN_1049
TNP: Tnap_1368
PMO: Pmob_1619
KOL: Kole_0213
DTH: DICTH_1030(ispH)
DTU: Dtur_1158
TYE: THEYE_A1769(ispH)
NDE: NIDE0859(ispH)
TTR: Tter_0639
DDF: DEFDS_2096(ispH)
Taxonomy
Reference
  Authors

  Title

  Journal
  Organism
 1  [PMID:11818558]
Rohdich F, Hecht S, Gartner K, Adam P, Krieger C, Amslinger S,
Arigoni D, Bacher A, Eisenreich W.
Studies on the nonmevalonate terpene biosynthetic pathway: metabolic
role of IspH (LytB) protein.
Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 1158-63.
Escherichia coli [GN:eco]
Reference
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  Journal
  Organism
 2  [PMID:11741609]
Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas
AK, Beck E, Wiesner J, Eberl M, Jomaa H.
Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as
a major activator for human gammadelta T cells in Escherichia coli.
FEBS. Lett. 509 (2001) 317-22.
Escherichia coli [GN:eco]
Reference
  Authors
  Title


  Journal
 3
Charon, L., Pale-Grosdemange, C. and Rohmer, M.
On the reduction steps in the mevalonate independent
2-C-methyl-D-erythritol 4-phosphate (MEP) pathway for isoprenoid
biosynthesis in the bacterium Zymomonas mobilis.
Tetrahedron Lett. 40 (1999) 7231-7234.
Reference
  Authors


  Title

  Journal
  Organism
 4  [PMID:16289098]
Rohrich RC, Englert N, Troschke K, Reichenberg A, Hintz M, Seeber F,
Balconi E, Aliverti A, Zanetti G, Kohler U, Pfeiffer M, Beck E,
Jomaa H, Wiesner J
Reconstitution of an apicoplast-localised electron transfer pathway
involved in the isoprenoid biosynthesis of Plasmodium falciparum.
FEBS. Lett. 579 (2005) 6433-8.
Plasmodium falciparum
Reference
  Authors

  Title


  Journal
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 5  [PMID:12706830]
Wolff M, Seemann M, Tse Sum Bui B, Frapart Y, Tritsch D, Garcia
Estrabot A, Rodriguez-Concepcion M, Boronat A, Marquet A, Rohmer M
Isoprenoid biosynthesis via the methylerythritol phosphate pathway:
the (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase
(LytB/IspH) from Escherichia coli is a [4Fe-4S] protein.
FEBS. Lett. 541 (2003) 115-20.
Escherichia coli [GN:eco]
Reference
  Authors


  Title

  Journal
  Organism
 6  [PMID:15469281]
Grawert T, Kaiser J, Zepeck F, Laupitz R, Hecht S, Amslinger S,
Schramek N, Schleicher E, Weber S, Haslbeck M, Buchner J, Rieder C,
Arigoni D, Bacher A, Eisenreich W, Rohdich F
IspH protein of Escherichia coli: studies on iron-sulfur cluster
implementation and catalysis.
J. Am. Chem. Soc. 126 (2004) 12847-55.
Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 1.17.1.2
IUBMB Enzyme Nomenclature: 1.17.1.2
ExPASy - ENZYME nomenclature database: 1.17.1.2
BRENDA, the Enzyme Database: 1.17.1.2
CAS: 512789-14-9
DBGET integrated database retrieval system