| Entry |
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| Name |
6-hydroxynicotinate dehydrogenase;
6-hydroxynicotinic acid hydroxylase;
6-hydroxynicotinic acid dehydrogenase;
6-hydroxynicotinate hydroxylase;
6-hydroxynicotinate:O2 oxidoreductase
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| Class |
Oxidoreductases;
Acting on CH or CH2 groups;
With oxygen as acceptor
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| Sysname |
6-hydroxynicotinate:oxygen oxidoreductase
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| Reaction(IUBMB) |
6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2 [RN: R07221]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Contains [2Fe-2S] iron-sulfur centres, FAD and molybdenum. It also has a catalytically essential, labile selenium that can be removed by reaction with cyanide. In Bacillus niacini, this enzyme is required for growth on nicotinic acid.
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| History |
EC 1.17.3.3 created 2004
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| Pathway |
| Nicotinate and nicotinamide metabolism |
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| Reference |
1 |
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| Authors |
Nagel, M. and Andreesen, J.R. |
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| Title |
Molybdenum-dependent degradation of nicotinic acid by Bacillus sp. DSM 2923. |
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| Journal |
FEMS Microbiol. Lett. 59 (1989) 147-152. |
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| Reference |
2 |
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| Authors |
Nagel, M. and Andreesen, J.R. |
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| Title |
Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini. |
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| Journal |
Arch. Microbiol. 154 (1990) 605-613. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 122191-32-6 |
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| LinkDB |
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