KEGG   ENZYME: 1.2.1.23Help
Entry
EC 1.2.1.23                 Enzyme                                 
Name
2-oxoaldehyde dehydrogenase (NAD+);
alpha-ketoaldehyde dehydrogenase;
methylglyoxal dehydrogenase;
NAD+-linked alpha-ketoaldehyde dehydrogenase;
2-ketoaldehyde dehydrogenase;
NAD+-dependent alpha-ketoaldehyde dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-oxoaldehyde:NAD+ 2-oxidoreductase
Reaction(IUBMB)
a 2-oxoaldehyde + NAD+ + H2O = a 2-oxo carboxylate + NADH + H+ [RN:R01337]
Reaction(KEGG)
R01337 > R00203;
(other) R01735
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Substrate
2-oxoaldehyde [CPD:C00538];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
2-oxo carboxylate;
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Not identical with EC 1.2.1.49 2-oxoaldehyde dehydrogenase (NADP+).
Pathway
Pyruvate metabolism
Reference
1  [PMID:4383524]
  Authors
Monder C.
  Title
Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate.
  Journal
J. Biol. Chem. 242 (1967) 4603-9.
  Organism
Ovis aries
Reference
2  [PMID:7107626]
  Authors
Ray M, Ray S.
  Title
On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase.
  Journal
J. Biol. Chem. 257 (1982) 10571-4.
  Organism
Capra hircus
Reference
3  [PMID:7107625]
  Authors
Ray S, Ray M.
  Title
Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate.
  Journal
J. Biol. Chem. 257 (1982) 10566-70.
  Organism
Capra hircus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37250-91-2
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