| Entry |
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| Name |
cannabidiolic acid synthase;
CBDA synthase
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| Class |
Oxidoreductases;
Catalysing the reaction X-H + Y-H = X-Y;
With oxygen as acceptor
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| Sysname |
cannabigerolate:oxygen oxidoreductase (cyclizing, cannabidiolate-forming)
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| Reaction(IUBMB) |
cannabigerolate + O2 = cannabidiolate + H2O2 [RN: R10160]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Binds FAD covalently. Part of the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme can also convert cannabinerolate to cannabidiolate with lower efficiency.
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| History |
EC 1.21.3.8 created 2012
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| Orthology |
| cannabidiolic acid synthase |
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| Reference |
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| Authors |
Taura F, Morimoto S, Shoyama Y |
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| Title |
Purification and characterization of cannabidiolic-acid synthase from Cannabis sativa L.. Biochemical analysis of a novel enzyme that catalyzes the oxidocyclization of cannabigerolic acid to cannabidiolic acid. |
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| Journal |
J. Biol. Chem. 271 (1996) 17411-6. |
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| Sequence |
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| Reference |
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| Authors |
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S |
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| Title |
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa. |
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| Journal |
FEBS. Lett. 581 (2007) 2929-34. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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