| Entry |
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| Name |
arogenate dehydrogenase;
arogenic dehydrogenase (ambiguous);
cyclohexadienyl dehydrogenase;
pretyrosine dehydrogenase (ambiguous);
L-arogenate:NAD+ oxidoreductase;
arogenate dehydrogenase (NAD+)
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
L-arogenate:NAD+ oxidoreductase (decarboxylating)
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| Reaction(IUBMB) |
L-arogenate + NAD+ = L-tyrosine + NADH + CO2 [RN: R00732]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). NAD+-specific enzymes have been reported from some bacteria [2] and plants [3]. Some enzymes also possess the activity of EC 1.3.1.12, prephenate dehydrogenase.
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| History |
EC 1.3.1.43 created 1989, modified 2003, modified 2005, modified 2015
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| Pathway |
| Phenylalanine, tyrosine and tryptophan biosynthesis | | Novobiocin biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
| cyclohexadieny/prephenate dehydrogenase |
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| Genes |
SNJ: | | PSO: | | PUR: | | PALI: | | PSPG: | | PSYG: | | PSYC: | | ACB: | | ABM: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ABJ: | | ABAB: | | ABAJ: | | ABAZ: | | ABK: | | ABAU: | | ABAA: | | ABW: | | ABAL: | | ACC: | | ANO: | | ACD: | | ACI: | | ATT: | | AEI: | | AJO: | | ACW: | | ACV: | | AHL: | | AJN: | | ASOL: | | ALA: | | ASJ: | | MCS: | | MCAT: | | MOI: | | MOS: | | MBL: | | MLO: | | MLN: | | MCI: | | MOP: | | MAM: | | MAMO: | | MESO: | | MESW: | | MES: | | HOE: | | AAK: | | PLA: | | SME: | | SMK: | | SMQ: | | SMX: | | SMI: | | SMEG: | | SMEL: | | SMER: | | SMD: | | RHI: | | SFH: | | SFD: | | SIX: | | SAME: | | EAD: | | EAH: | | ATU: | | ARA: | | ATF: | | ATA: | | AVI: | | AGR: | | AGC: | | ARO: | | RET: | | REC: | | REL: | | REI: | | REP: | | RLE: | | RLT: | | RLG: | | RLB: | | RLU: | | RTR: | | RIR: | | RHL: | | RGA: | | RHN: | | RPHA: | | RHT: | | RHX: | | NGL: | | NGG: | | LCC: | | SHZ: | | BME: | | BMEL: | | BMI: | | BMZ: | | BMG: | | BMW: | | BMEE: | | BMF: | | BMB: | | BMC: | | BAA: | | BABO: | | BABR: | | BABT: | | BABB: | | BABU: | | BABS: | | BABC: | | BMS: | | BSI: | | BSF: | | BSUI: | | BSUP: | | BSUV: | | BSUC: | | BMT: | | BSZ: | | BSV: | | BSW: | | BSG: | | BOV: | | BCS: | | BSK: | | BOL: | | BCAR: | | BCAS: | | BMR: | | BPP: | | BPV: | | BCET: | | BCEE: | | BVL: | | OAN: | | OAH: | | OPS: | | BJA: | | BJU: | | BJP: | | BRA: | | BBT: | | BRS: | | AOL: | | BRC: | | BRAD: | | BIC: | | RPA: | | RPB: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | NWI: | | NHA: | | OCA: | | OCG: | | OCO: | | BOP: | | BOS: | | BVV: | | BHE: | | BHN: | | BHS: | | BQU: | | BQR: | | BTR: | | BTX: | | BGR: | | BVN: | | XAU: | | AZC: | | SNO: | | MEX: | | MEA: | | MDI: | | MCH: | | MRD: | | MET: | | MPO: | | MNO: | | MOR: | | META: | | MAQU: | | BID: | | MSL: | | CHEL: | | CDQ: | | HDN: | | HDT: | | HMC: | | HNI: | | RVA: | | PHL: | | FIL: | | FIY: | | DEQ: | | BVR: | | RHZ: | | MSC: | | MBRY: | | MEY: | | MAAD: | | MMED: | | AUA: | | MCG: | | THD: | | PSIN: | | RBM: | | CCR: | | CCS: | | CAK: | | CSE: | | CHQ: | | CBOT: | | SIL: | | SIT: | | RMB: | | RSP: | | RSH: | | RSQ: | | RSK: | | RCP: | | RHP: | | JAN: | | RDE: | | RLI: | | PDE: | | PAMI: | | PYE: | | PCON: | | DSH: | | KVU: | | KVL: | | KRO: | | PSF: | | PGA: | | PGL: | | PGD: | | PHP: | | OAT: | | OAR: | | OTM: | | LMD: | | RED: | | PTP: | | CID: | | CMAR: | | MALG: | | CON: | | RSU: | | RHM: | | RHC: | | PPHR: | | HAT: | | LAP: | | LAGG: | | DAA: | | YAN: | | SUAM: | | DON: | | TPRO: | | TOM: | | PABY: | | THW: | | RMM: | | LVS: | | HNE: | | HBA: | | ZMO: | | ZMN: | | ZMM: | | ZMB: | | ZMI: | | ZMC: | | ZMR: | | ZMP: | | NAR: | | NPP: | | NPN: | | NRE: | | SAL: | | SPHK: | | SPHP: | | SMAG: | | SMAZ: | | STER: | | SGI: | | SPHL: | | SPHQ: | | SWI: | | SPHM: | | STAX: | | SPHI: | | SSAN: | | SMY: | | SPAN: | | SPLM: | | SJP: | | SCH: | | SSY: | | SYB: | | SBD: | | SPMI: | | SPHB: | | SPHR: | | SINB: | | SPHG: | | BLAS: | | ELI: | | ELQ: | | ERY: | | EGN: | | AAY: | | AMX: | | AEP: | | ANH: | | ADO: | | CNA: | | CMAN: | | PNS: | | PORL: | | GOX: | | GOH: | | GOY: | | GAL: | | GBE: | | GBH: | | GBC: | | GBS: | | ACR: | | AMV: | | GDI: | | GDJ: | | GXY: | | GXL: | | KNA: | | KEU: | | APT: | | APW: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | APK: | | ASZ: | | ASV: | | AACE: | | APER: | | ABG: | | KBA: | | RGI: | | NCH: | | RRU: | | RRF: | | RCE: | | RPM: | | MAG: | | MGY: | | MAGX: | | MAGN: | | AZL: | | ALI: | | ABS: | | ABQ: | | ABF: | | ATI: | | TMO: | | TXI: | | MAGQ: | | HJO: | | PBR: | | PGV: | | PEL: | | APC: | | APM: | | APB: | | OBG: | | OBT: | | AGL: | | VBA: | | GES: | | PHM: | | VBL: | | MOX: | |
» show all
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| Reference |
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| Authors |
Stenmark SL, Pierson DL, Jensen RA, Glover GI. |
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| Title |
Blue-green bacteria synthesise L-tyrosine by the pretyrosine pathway. |
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| Journal |
Nature. 247 (1974) 290-2. |
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| Reference |
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| Authors |
Byng GS, Whitaker RJ, Gherna RL, Jensen RA |
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| Title |
Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae. |
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| Journal |
J. Bacteriol. 144 (1980) 247-57. |
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| Reference |
3 |
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| Authors |
Byng, G., Whitaker, R., Flick, C. and Jensen, R.A. |
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| Title |
Enzymology of L-tyrosine biosynthesis in corn (Zea mays). |
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| Journal |
Phytochemistry 20 (1981) 1289-1292. |
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| Reference |
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| Authors |
Mayer E, Waldner-Sander S, Keller B, Keller E, Lingens F. |
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| Title |
Purification of arogenate dehydrogenase from Phenylobacterium immobile. |
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| Journal |
FEBS. Lett. 179 (1985) 208-12. |
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| Reference |
5 |
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| Authors |
Lingens, F., Keller, E. and Keller, B. |
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| Title |
Arogenate dehydrogenase from Phenylobacterium immobile. |
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| Journal |
Methods Enzymol. 142 (1987) 513-518. |
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| Reference |
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| Authors |
Zamir LO, Tiberio R, Devor KA, Sauriol F, Ahmad S, Jensen RA. |
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| Title |
Structure of D-prephenyllactate. A carboxycyclohexadienyl metabolite from Neurospora crassa. |
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| Journal |
J. Biol. Chem. 263 (1988) 17284-90. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 64295-75-6 |
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| LinkDB |
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