Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor

glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)

glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein (overall reaction) [RN:R02488];
(1a) glutaryl-CoA + electron-transfer flavoprotein = (E)-glutaconyl-CoA + reduced electron-transfer flavoprotein [RN:R10074];
(1b) (E)-glutaconyl-CoA = crotonyl-CoA + CO2 [RN:R03028]

R02488 > R02487;
R03028 R10074

glutaryl-CoA [CPD:C00527];
electron-transfer flavoprotein [CPD:C04253];
(E)-glutaconyl-CoA [CPD:C02411]

Contains FAD. The enzyme catalyses the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 4.1.1.70, glutaconyl-CoA decarboxylase). FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyses the oxidation to glutaconyl-CoA (EC 1.3.99.32).

EC 1.3.8.6 created 1972 as EC 1.3.99.7, transferred 2012 to EC 1.3.8.6, modified 2013