| Entry |
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| Name |
aralkylamine dehydrogenase (azurin);
aromatic amine dehydrogenase;
arylamine dehydrogenase;
tyramine dehydrogenase;
aralkylamine:(acceptor) oxidoreductase (deaminating)
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| Class |
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With a copper protein as acceptor
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| Sysname |
aralkylamine:azurin oxidoreductase (deaminating)
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| Reaction(IUBMB) |
ArCH2NH2 + H2O + 2 azurin = ArCHO + NH3 + 2 reduced azurin
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| Reaction(KEGG) |
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| Substrate |
ArCH2NH2;
H2O [CPD: C00001];
azurin
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| Product |
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| Comment |
Phenazine methosulfate can act as acceptor. Acts on aromatic amines and, more slowly, on some long-chain aliphatic amines, but not on methylamine or ethylamine
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| History |
EC 1.4.9.2 created 1986 as EC 1.4.99.4, transferred 2011 to 1.4.9.2
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| Pathway |
| Tyrosine metabolism | | Phenylalanine metabolism | | Isoquinoline alkaloid biosynthesis | | Metabolic pathways | | Biosynthesis of secondary metabolites |
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| Orthology |
| aralkylamine dehydrogenase light chain | | aralkylamine dehydrogenase heavy chain |
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| Genes |
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| Reference |
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| Authors |
Iwaki M, Yagi T, Horiike K, Saeki Y, Ushijima T, Nozaki M. |
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| Title |
Crystallization and properties of aromatic amine dehydrogenase from Pseudomonas sp. |
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| Journal |
Arch. Biochem. Biophys. 220 (1983) 253-62. |
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| Reference |
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| Authors |
Hyun YL, Davidson VL |
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| Title |
Electron transfer reactions between aromatic amine dehydrogenase and azurin. |
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| Journal |
Biochemistry. 34 (1995) 12249-54. |
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| Reference |
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| Authors |
Hyun YL, Zhu Z, Davidson VL |
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| Title |
Gated and ungated electron transfer reactions from aromatic amine dehydrogenase to azurin. |
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| Journal |
J. Biol. Chem. 274 (1999) 29081-6. |
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| Reference |
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| Authors |
Davidson VL |
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| Title |
Electron transfer in quinoproteins. |
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| Journal |
Arch. Biochem. Biophys. 428 (2004) 32-40. |
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| Reference |
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| Authors |
Sukumar N, Chen ZW, Ferrari D, Merli A, Rossi GL, Bellamy HD, Chistoserdov A, Davidson VL, Mathews FS |
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| Title |
Crystal structure of an electron transfer complex between aromatic amine dehydrogenase and azurin from Alcaligenes faecalis. |
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| Journal |
Biochemistry. 45 (2006) 13500-10. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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