KEGG   ENZYME: 1.5.1.17Help
Entry
EC 1.5.1.17                 Enzyme                                 

Name
alanopine dehydrogenase;
ALPDH ;
alanopine[meso-N-(1-carboxyethyl)-alanine]dehydrogenase;
meso-N-(1-carboxyethyl)-alanine:NAD+ oxidoreductase;
alanopine: NAD+ oxidoreductase;
ADH;
alanopine:NAD+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,2'-iminodipropanoate:NAD+ oxidoreductase (L-alanine-forming)
Reaction(IUBMB)
2,2'-iminodipropanoate + NAD+ + H2O = L-alanine + pyruvate + NADH + H+ [RN:R00398]
Reaction(KEGG)
Substrate
2,2'-iminodipropanoate [CPD:C03210];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
L-alanine [CPD:C00041];
pyruvate [CPD:C00022];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
In the reverse reaction, L-alanine can be replaced by L-cysteine, L-serine or L-threonine; glycine acts very slowly (cf. EC 1.5.1.22 strombine dehydrogenase).
History
EC 1.5.1.17 created 1983, modified 1986
Reference
1
  Authors
Dando, P.R.
  Title
Strombine [N-(carboxymethyl)-D-alanine] dehydrogenase and alanopine [meso-N-(1-carboxyethyl)-alanine dehydrogenase from the mussel Mytilus edulis L.
  Journal
Biochem. Soc. Trans. 9 (1981) 297-298.
Reference
2  [PMID:6156653]
  Authors
Fields JH, Eng AK, Ramsden WD, Hochachka PW, Weinstein B.
  Title
Alanopine and strombine are novel imino acids produced by a dehydrogenase found in the adductor muscle of the oyster, Crassostrea gigas.
  Journal
Arch. Biochem. Biophys. 201 (1980) 110-4.
  Organism
Crassostrea gigas
Reference
3  [PMID:7238503]
  Authors
Fields JH, Hochachka PW.
  Title
Purification and properties of alanopine dehydrogenase from the adductor muscle of the oyster, Crassostrea gigas (Mollusca, Bivalvia).
  Journal
Eur. J. Biochem. 114 (1981) 615-21.
  Organism
Crassostrea gigas
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
71343-07-2
LinkDB All DBs

DBGET integrated database retrieval system