KEGG   ENZYME: 1.5.3.16Help
Entry
EC 1.5.3.16                 Enzyme                                 

Name
spermine oxidase;
PAOh1/SMO;
PAOh1 (ambiguous);
AtPAO1;
AtPAO4;
SMO;
mSMO;
SMO(PAOh1);
SMO/PAOh1;
SMO5;
mSMOmu
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
spermidine:oxygen oxidoreductase (spermidine-forming)
Reaction(IUBMB)
spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 [RN:R09076]
Reaction(KEGG)
Substrate
spermine [CPD:C00750];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
spermidine [CPD:C00315];
3-aminopropanal [CPD:C05665];
H2O2 [CPD:C00027]
Comment
The enzyme from Arabidopsis thaliana (AtPAO1) oxidizes norspermine to norspermidine with high efficiency [3]. The mammalian enzyme, encoded by the SMOX gene, is a cytosolic enzyme that catalyses the oxidation of spermine at the exo (three-carbon) side of the tertiary amine. No activity with spermidine. Weak activity with N1-acetylspermine. A flavoprotein (FAD). Differs in specificity from EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming) and EC 1.5.3.17 (non-specific polyamine oxidase).
History
EC 1.5.3.16 created 2009
Pathway
Arginine and proline metabolism
beta-Alanine metabolism
Orthology
K12259  
spermine oxidase
K13366  
polyamine oxidase
Genes
HSA: 
54498(SMOX)
PTR: 
458074(SMOX)
PPS: 
100983105(SMOX)
GGO: 
101133425(SMOX)
PON: 
100462330(SMOX)
NLE: 
100586685(SMOX)
MCC: 
718761(SMOX)
MCF: 
101867246(SMOX)
CSAB: 
103247041(SMOX)
RRO: 
104674589(SMOX)
CJC: 
100397119(SMOX)
SBQ: 
101038093(SMOX)
MMU: 
228608(Smox)
RNO: 
308652(Smox)
CGE: 
100763379(Smox)
NGI: 
103736403(Smox)
HGL: 
101707899(Smox)
CCAN: 
109701346(Smox)
OCU: 
100347645(SMOX)
TUP: 
102477539(SMOX)
CFA: 
485787(SMOX)
AML: 
100480545(SMOX)
UMR: 
103674402(SMOX)
FCA: 
101084867(SMOX)
PTG: 
102953447(SMOX)
AJU: 
106980151(SMOX)
BTA: 
527211(SMOX)
BOM: 
102278225(SMOX)
BIU: 
109567182(SMOX)
PHD: 
102342141(SMOX)
CHX: 
102176898(SMOX)
OAS: 
101118975(SMOX)
SSC: 
100152781(SMOX)
CFR: 
102519491(SMOX)
BACU: 
103015742(SMOX)
LVE: 
103072563(SMOX)
ECB: 
100052311(SMOX)
MYB: 
102248159(SMOX)
MYD: 
102768889(SMOX)
HAI: 
109383858(SMOX)
RSS: 
109440697 109448463(SMOX)
PALE: 
102891646(SMOX)
LAV: 
100671284(SMOX)
MDO: 
100030883(SMOX)
SHR: 
100917297 100926267(SMOX)
OAA: 
100085736(SMOX)
GGA: 
422934(SMOX)
MGP: 
100540689(SMOX)
CJO: 
107314119(SMOX)
APLA: 
101789809(SMOX)
TGU: 
100232049(SMOX)
GFR: 
102037069(SMOX)
FAB: 
101815717(SMOX)
PHI: 
102104257(SMOX)
CCW: 
104690827(SMOX)
FPG: 
101911959(SMOX)
FCH: 
102050731(SMOX)
CLV: 
102085808(SMOX)
AAM: 
106489575(SMOX)
ASN: 
102381757(SMOX)
AMJ: 
102561876(SMOX)
PSS: 
102458431(SMOX)
CMY: 
102934652(SMOX)
CPIC: 
101941185(SMOX)
ACS: 
100556339(smox)
PBI: 
103052732(SMOX)
GJA: 
107110397(SMOX)
XLA: 
108697130(smox.L) 108706499
XTR: 
733959(smox)
DRE: 
387290(smox) 564675(paox1)
IPU: 
108260499(smox) 108266459 108266460
TRU: 
101071609(smox)
TNG: 
GSTEN00033491G001
LCO: 
104926977(smox)
MZE: 
101476223(smox)
OLA: 
101164210(smox)
XMA: 
102226933(smox)
CSEM: 
107988054(smox)
SASA: 
106602764 106609979
LCM: 
102345401 102347336 102363700
CMK: 
103181501(smox)
BFO: 
BRAFLDRAFT_122801 BRAFLDRAFT_125091 BRAFLDRAFT_56994 BRAFLDRAFT_63612 BRAFLDRAFT_81216 BRAFLDRAFT_83047 BRAFLDRAFT_87971
CIN: 
100183817
SKO: 
100372068 100373364 100378024
PXY: 
105387330
API: 
100159958
PHU: 
Phum_PHUM512540
DPX: 
DAPPUDRAFT_311731
ISC: 
IscW_ISCW005123
HRO: 
HELRODRAFT_191961
LGI: 
LOTGIDRAFT_114635 LOTGIDRAFT_235550
CRG: 
105319590 105321727 105339316
OBI: 
106875038
NVE: 
NEMVE_v1g181733 NEMVE_v1g201904
ADF: 
107332810 107345156 107345988 107348044 107352195
HMG: 
100214989
TAD: 
TRIADDRAFT_51683
AQU: 
100636554 105312559 105312612 105314086 105314087 105314417 105315072 105315675 105316622
ATH: 
AT4G29720(PAO5) AT5G13700(PAO1)
ALY: 
ARALYDRAFT_491790
CRB: 
CARUB_v10003804mg CARUB_v10004550mg
EUS: 
EUTSA_v10015601mg EUTSA_v10024841mg
BRP: 
103853354 103856027 103861899
BNA: 
106386332 106387661 106402283 106431030 106431049 106440920
THJ: 
104803973 104807074 104814620 104819089 104820132 104826685
CIT: 
102606898 102609290 102616414 102628850
CIC: 
CICLE_v10007864mg CICLE_v10016050mg CICLE_v10017492mg CICLE_v10031331mg
TCC: 
18588398 18614594
GRA: 
105768758 105790586 105791756 105792069
GHI: 
107900764 107907142 107916282 107932214 107937735 107942395
EGR: 
104436487 104454637 104455974
GMX: 
100778778 100783032 100798929 100805182 100806601 100809630 100809633 106796594
PVU: 
PHAVU_003G136900g PHAVU_005G023400g PHAVU_009G232400g
VRA: 
106756239 106761584 106762597 106767895
VAR: 
108322708 108329945 108332541 108338795
CCAJ: 
109790464 109792286 109798463 109805531
MTR: 
MTR_2g039160 MTR_3g033000
CAM: 
101499173 101501004
ADU: 
107462739 107477455 107478955 107496621
AIP: 
107614549 107629684 107630372 107643022
LJA: 
Lj3g3v0824920.1(Lj3g3v0824920.1) Lj6g3v1269730.1(Lj6g3v1269730.1) Lj6g3v1269740.1(Lj6g3v1269740.1)
LANG: 
109327042 109327286 109347423 109347912 109355998 109362538
FVE: 
101293630 101293925
PPER: 
18771555 18785878
PMUM: 
103330642 103330668 103340722
MDM: 
103406811 103412969(PAO) 103423625 103431534 103438425 103450386
PXB: 
103943993 103945491 103951857 103957582
ZJU: 
107423979 107425742 107431462 107435113
CSV: 
101205432 101209263
CMO: 
103498503 103499947
RCU: 
8259286 8272548 8289023
JCU: 
105628733 105637880 105640396 105640397
POP: 
POPTR_0001s27060g(POPTRDRAFT_839752) POPTR_0006s15580g(POPTRDRAFT_561090) POPTR_0009s06330g POPTR_0012s08090g(POPTRDRAFT_422519) POPTR_0015s08590g(POPTRDRAFT_666455)
VVI: 
100241347 100243887 100244793 100256912 100260168
SLY: 
101244015 101249640 101253022 101266198
SPEN: 
107006997 107009669 107018597 107024268
SOT: 
102579310 102581392 102597076 102603548 102605774
INI: 
109148083 109151238 109180905 109186747
SIND: 
105162000 105169299 105172222 105173463
BVG: 
104884237 104899694 104907724 104908694 104908696 104908748
NNU: 
104585880 104586622 104587194 104587236 104597370 104600721
OSA: 
4327828 4346881(OJ1759_F09.3) 4346882(OJ1759_F09.8)
DOSA: 
Os01t0710200-00(Os01g0710200) Os03t0193400-00(Os03g0193400) Os09t0368200-00(Os09g0368200) Os09t0368500-01(Os09g0368500)
OBR: 
102707819 102722471 102722749
BDI: 
100823564 100838312
ATS: 
F775_13792 F775_26980 F775_28632 F775_31003
SBI: 
8059172 8085037
ZMA: 
100383200 103632539 541983(pao1)
SITA: 
101770424 101771622 101782987
PDA: 
103699301 103713355
EGU: 
105032618 105056213
MUS: 
103979667 103981757 103984275 103989023 103989771
ATR: 
18434810 18440865 18446729 18448170
SMO: 
SELMODRAFT_121066 SELMODRAFT_124096 SELMODRAFT_178874 SELMODRAFT_410626 SELMODRAFT_424911 SELMODRAFT_439136 SELMODRAFT_446650 SELMODRAFT_83558
CSL: 
COCSUDRAFT_60746
CVR: 
CHLNCDRAFT_142163
APRO: 
F751_0494
GSL: 
Gasu_30450
CCP: 
CHC_T00003381001
FGR: 
FGSG_03761
FPU: 
FPSE_03487
FVR: 
FVEG_10907 FVEG_11714 FVEG_12823
FOX: 
FOXG_12206 FOXG_16797 FOXG_17483
NHE: 
NECHADRAFT_31528 NECHADRAFT_51366 NECHADRAFT_52373
MAW: 
MAC_00210
MAJ: 
MAA_04956
CMT: 
CCM_08989
VAL: 
VDBG_02333
VDA: 
VDAG_02801
CFJ: 
CFIO01_12473
ELA: 
UCREL1_2158
PSCO: 
LY89DRAFT_713167
GLZ: 
GLAREA_04589
ANI: 
AN6658.2
AFM: 
AFUA_5G09720 AFUA_6G03510
AOR: 
AOR_1_560024(AO090010000340) AOR_1_898184(AO090009000545)
ANG: 
ANI_1_1218084(An09g02560) ANI_1_334114(An13g02480)
AFV: 
AFLA_049510 AFLA_077160 AFLA_118340
ACT: 
ACLA_013020 ACLA_097050
NFI: 
NFIA_050000 NFIA_077590
PCS: 
Pc18g02250
PDP: 
PDIP_73980
ABE: 
ARB_01705
TVE: 
TRV_03400
PNO: 
SNOG_00498
PTE: 
PTT_12979
BZE: 
COCCADRAFT_41279
BSC: 
COCSADRAFT_117097
BOR: 
COCMIDRAFT_96363
ZTR: 
MYCGRDRAFT_90917
BCOM: 
BAUCODRAFT_573844
NPA: 
UCRNP2_2910
PPL: 
POSPLDRAFT_21614
TVS: 
TRAVEDRAFT_128410 TRAVEDRAFT_128490
DSQ: 
DICSQDRAFT_88157
PCO: 
PHACADRAFT_126448
SHS: 
STEHIDRAFT_166485
HIR: 
HETIRDRAFT_43157(pao1) HETIRDRAFT_471084
GTR: 
GLOTRDRAFT_50424 GLOTRDRAFT_82515
LBC: 
LACBIDRAFT_248869
MPR: 
MPER_10583
MRR: 
Moror_12649 Moror_12657
SCM: 
SCHCODRAFT_40183
CPUT: 
CONPUDRAFT_84646
SLA: 
SERLADRAFT_354437
ACAN: 
ACA1_122700
EHX: 
EMIHUDRAFT_116825
 » show all
Taxonomy
Reference
1  [PMID:18422650]
  Authors
Murray-Stewart T, Wang Y, Goodwin A, Hacker A, Meeker A, Casero RA Jr
  Title
Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology.
  Journal
FEBS. J. 275 (2008) 2795-806.
  Sequence
[hsa:54498]
Reference
2  [PMID:12458219]
  Authors
Cervelli M, Polticelli F, Federico R, Mariottini P
  Title
Heterologous expression and characterization of mouse spermine oxidase.
  Journal
J. Biol. Chem. 278 (2003) 5271-6.
Reference
3  [PMID:16778015]
  Authors
Tavladoraki P, Rossi MN, Saccuti G, Perez-Amador MA, Polticelli F, Angelini R, Federico R
  Title
Heterologous expression and biochemical characterization of a polyamine oxidase from Arabidopsis involved in polyamine back conversion.
  Journal
Plant. Physiol. 141 (2006) 1519-32.
  Sequence
[ath:AT5G13700]
Reference
4  [PMID:12727196]
  Authors
Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA Jr
  Title
Properties of purified recombinant human polyamine oxidase, PAOh1/SMO.
  Journal
Biochem. Biophys. Res. Commun. 304 (2003) 605-11.
  Sequence
[hsa:54498]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
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