KEGG ENZYME: 1.5.3.17

ENZYME: 1.5.3.17

Entry

EC 1.5.3.17 Enzyme

Name

non-specific polyamine oxidase;
polyamine oxidase (ambiguous);
Fms1;
AtPAO3

Class

Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor

Sysname

polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming)

Reaction(IUBMB)

(1) spermine + O2 + H2O = spermidine + 3-aminopropanal + H2O2 [RN:R09076];
(2) spermidine + O2 + H2O = putrescine + 3-aminopropanal + H2O2 [RN:R09077];
(3) N1-acetylspermine + O2 + H2O = spermidine + 3-acetamidopropanal + H2O2 [RN:R03899];
(4) N1-acetylspermidine + O2 + H2O = putrescine + 3-acetamidopropanal + H2O2 [RN:R09074]

Reaction(KEGG)

R03899 R09074 R09076 R09077

Substrate

spermine [CPD:C00750];
O2 [CPD:C00007];
H2O [CPD:C00001];
spermidine [CPD:C00315];
N1-acetylspermine [CPD:C02567];
N1-acetylspermidine [CPD:C00612]

Product

spermidine [CPD:C00315];
3-aminopropanal [CPD:C05665];
H2O2 [CPD:C00027];
putrescine [CPD:C00134];
3-acetamidopropanal [CPD:C18170]

Comment

A flavoprotein (FAD). The non-specific polyamine oxidases may differ from each other considerably. The enzyme from Saccharomyces cerevisiae shows a rather broad specificity and also oxidizes N8-acetylspermidine [3]. The enzyme from Ascaris suum shows high activity with spermine and spermidine, but also oxidizes norspermine [2]. The enzyme from Arabidopsis thaliana shows high activity with spermidine, but also oxidizes other polyamines [1].
The specific polyamine oxidases are classified as EC 1.5.3.13 (N1-acetylpolyamine oxidase), EC 1.5.3.14 (polyamine oxidase (propane-1,3-diamine-forming)), EC 1.5.3.15 (N8-acetylspermidine oxidase (propane-1,3-diamine-forming)) and EC 1.5.3.16 (spermine oxidase).

History

EC 1.5.3.17 created 2009

Pathway

ec00330	Arginine and proline metabolism
ec00410	beta-Alanine metabolism

Orthology

K13367	polyamine oxidase
K17839	polyamine oxidase

Genes

ATH:	AT1G65840(PAO4) AT2G43020(PAO2) AT3G59050(PAO3)
ALY:	ARALYDRAFT_483403 ARALYDRAFT_486367 ARALYDRAFT_894198
CRB:	CARUB_v10019588mg CARUB_v10020181mg CARUB_v10023090mg
EUS:	EUTSA_v10005954mg EUTSA_v10016573mg EUTSA_v10018447mg
BRP:	103830193 103852299 103858041 103866035 103866687
BNA:	106351646 106351654 106353169 106381329 106385479 106391704 106421166 106428226 106434498 106441217
THJ:	104803407 104805661 104821208 104822137
CIT:	102624788 102625282 102627867
CIC:	CICLE_v10011567mg CICLE_v10031239mg
TCC:	18612191
GRA:	105763643 105790392
GHI:	107916881 107925953 107944271 107945473
EGR:	104422211 104442425
GMX:	100782576 100785056 100790521 100791090 100798561 100799631 100806878 100811255 106799305
PVU:	PHAVU_006G028600g PHAVU_006G085900g PHAVU_008G196900g PHAVU_008G241700g
VRA:	106753045 106765160 106765271 106776036
VAR:	108337267 108338488 108343091 108343161
CCAJ:	109790272 109795185 109795282
MTR:	MTR_3g064370 MTR_3g449620 MTR_5g090300
CAM:	101488772 101489745 101514322
ADU:	107458090 107480998 107496522
AIP:	107610087 107631405
LJA:	Lj2g3v3070860.1(Lj2g3v3070860.1) Lj2g3v3070870.1(Lj2g3v3070870.1) Lj2g3v3070870.2(Lj2g3v3070870.2) Lj6g3v0366930.1(Lj6g3v0366930.1) Lj6g3v0933770.1(Lj6g3v0933770.1)
LANG:	109330188 109339566 109356838
FVE:	101293234 101293991
PPER:	18782544 18782903
PMUM:	103327360 103328951
MDM:	103405136 103405900 103426256 103443150 103444375
PXB:	103933878 103947391 103956795 103956798 103959927 103965587
ZJU:	107416625
CSV:	101205765 101213852
CMO:	103493008 103502485
RCU:	8273410 8277860
JCU:	105634456 105634459 105636130
POP:	POPTR_0002s05620g(POPTRDRAFT_1071346) POPTR_0004s07430g(POPTRDRAFT_817951) POPTR_0005s22880g(POPTRDRAFT_831582) POPTR_0017s01520g
VVI:	100245491 100250153
SLY:	101252005 101258232 101260014 101264170
SPEN:	107007559 107011311 107012957 107026194
SOT:	102591553 102594410 102598184 102605222
INI:	109167577 109172637 109187541
SIND:	105167429 105175973 105178573
BVG:	104891257 104902678
NNU:	104588475 104607001 104610796
OSA:	4337046 4337360
DOSA:	Os04t0623300-01(Os04g0623300) Os04t0671200-01(Os04g0671200) Os04t0671300-01(Os04g0671300)
OBR:	102710582 102711526 102711798
BDI:	100824039 100840588 100841193
ATS:	F775_26735 F775_27550
SBI:	8074727 8082590
ZMA:	100191603(pco077065) 100384522(TIDP3366) 101027113 103631209 103631435 103631626 103642073
SITA:	101753072 101753473 101768863
PDA:	103699682 103703721 103705589 103717571 103723706
EGU:	105033992 105035498 105035697 105058904 105059362
MUS:	103971799 103973550 103983690 103998527
ATR:	18427217 18437742
SMO:	SELMODRAFT_22558 SELMODRAFT_22584 SELMODRAFT_270153 SELMODRAFT_271685 SELMODRAFT_439374 SELMODRAFT_440258
PPP:	PHYPADRAFT_205047 PHYPADRAFT_221086
SCE:	YMR020W(FMS1)
AGO:	AGOS_ABR057W
ERC:	Ecym_4580
KLA:	KLLA0E07789g
LTH:	KLTH0D07942g
ZRO:	ZYRO0E06314g
CGR:	CAGL0M07612g
NCS:	NCAS_0A12730(NCAS0A12730)
NDI:	NDAI_0B01530(NDAI0B01530)
TDL:	TDEL_0B06550(TDEL0B06550)
KAF:	KAFR_0A02140(KAFR0A02140)
DHA:	DEHA2A02552g
PIC:	PICST_28515(CPB2) PICST_57813
PGU:	PGUG_01595
SPAA:	SPAPADRAFT_59154 SPAPADRAFT_72688
LEL:	LELG_04349
CAL:	CAALFM_C402040WA(CaO19.4589) CAALFM_CR09270CA(CBP1)
CTP:	CTRG_00245 CTRG_05911
COT:	CORT_0G01470 CORT_0G01480
CDU:	CD36_34620(CBP1) CD36_41930
CTEN:	CANTEDRAFT_112827
CLU:	CLUG_02138 CLUG_02198
CAUR:	QG37_03853
PDP:	PDIP_27570
ZTR:	MYCGRDRAFT_110027
PFJ:	MYCFIDRAFT_86444
AAF:	AURANDRAFT_65354

» show all

Reference

1 [PMID:18583528]

Authors

Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA

Title

Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis.

Journal

Plant. Physiol. 147 (2008) 1845-57.

Sequence

[ath:AT3G59050]

Reference

2 [PMID:1567380]

Authors

Muller S, Walter RD

Title

Purification and characterization of polyamine oxidase from Ascaris suum.

Journal

Biochem. J. 283 ( Pt 1) (1992) 75-80.