KEGG   ENZYME: 1.5.3.19Help
Entry
EC 1.5.3.19                 Enzyme                                 

Name
4-methylaminobutanoate oxidase (formaldehyde-forming);
mabO (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
4-methylaminobutanoate + O2 + H2O = 4-aminobutanoate + formaldehyde + H2O2 [RN:R10102]
Reaction(KEGG)
Substrate
4-methylaminobutanoate;
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
4-aminobutanoate [CPD:C00334];
formaldehyde [CPD:C00067];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). In the enzyme from the soil bacterium Arthrobacter nicotinovorans the cofactor is covalently bound. Participates in the nicotine degradation pathway of this organism.
History
EC 1.5.3.19 created 2012
Pathway
Nicotinate and nicotinamide metabolism
Microbial metabolism in diverse environments
Orthology
K19191  
4-methylaminobutanoate oxidase (formaldehyde-forming)
Genes
PHD: 
MHC: 
HJA: 
OAI: 
OME: 
TSN: 
REH: 
H16_B1955(gcvT3)
CNC: 
CTI: 
BGL: 
BGP: 
BGL_1c10300(sardh)
BGU: 
KS03_1930
BUG: 
BC1001_5775
BGE: 
BC1002_6651
BGD: 
bgla_1g11310
BGO: 
BM43_2471
BYI: 
BYI23_B001700
BUE: 
BRPE67_BCDS04100
BUQ: 
AC233_33115
BPLA: 
bpln_1g09850
BXE: 
Bxe_B1666
BXB: 
DR64_6973
BPH: 
Bphy_3161
BPX: 
BUPH_04519 BUPH_06021
BPY: 
Bphyt_4985
BFN: 
OI25_4099
BCAI: 
K788_0002785
PPK: 
U875_20775
PPNO: 
DA70_13465
PPNM: 
LV28_17235
PRB: 
X636_13400
PPUL: 
RO07_11360
PSPU: 
NA29_07175
PAPI: 
SG18_11740
PVE: 
UC34_03055
POX: 
MB84_07550
PTX: 
ABW99_14245
PFG: 
AB870_14270
PNR: 
AT302_11190
LIM: 
L103DPR2_01233(mlr)
RGE: 
RGE_31450
LLU: 
AKJ09_08073
MRM: 
A7982_09289
MLO: 
mll5369 mlr1283
MLN: 
A9174_00795 A9174_20000
MCI: 
Mesci_0159 Mesci_3329 Mesci_5294
MOP: 
Mesop_0158 Mesop_3820 Mesop_5916
MAM: 
Mesau_00160 Mesau_03609 Mesau_05390
MAMO: 
A6B35_06950 A6B35_21970
MESO: 
BSQ44_08170 BSQ44_15815 BSQ44_15870
MESW: 
A9K65_000760 A9K65_018010 A9K65_028955
HOE: 
IMCC20628_00238 IMCC20628_00540 IMCC20628_02182
AAK: 
AA2016_2970 AA2016_5410 AA2016_5857
SME: 
SM_b21534 SMc01662
SMK: 
Sinme_2254 Sinme_4737
SMQ: 
SinmeB_2098 SinmeB_3696
SMX: 
SM11_chr0984 SM11_pD0626
SMI: 
BN406_02098 BN406_05690(SARDH)
SMEG: 
C770_GR4Chr2333 C770_GR4pD0611
SMEL: 
SM2011_b21534 SM2011_c01662
SMER: 
DU99_12725 DU99_28565
SMD: 
Smed_2197 Smed_4871
RHI: 
NGR_b16520 NGR_c21810
SFH: 
SFHH103_02077
SFD: 
USDA257_c17540(gcvT1) USDA257_c24400(gcvT2) USDA257_c45730(gcvT4)
SIX: 
BSY16_4844 BSY16_523 BSY16_5615 BSY16_5617
SAME: 
SAMCFNEI73_Ch2543(gcvT)
EAD: 
OV14_3708 OV14_b0086
EAH: 
FA04_11565 FA04_31280
ARA: 
Arad_3548
AGC: 
BSY240_18 BSY240_19
RET: 
RHE_CH00088
REL: 
REMIM1_CH00091
REI: 
IE4771_CH00094
REP: 
IE4803_CH00094
RLE: 
RL0097
RLT: 
Rleg2_3311
RLG: 
Rleg_4350
RLB: 
RLEG3_32760
RLU: 
RLEG12_31745
RTR: 
RTCIAT899_CH14075
RHL: 
LPU83_0169
RGA: 
RGR602_CH00096
RHN: 
AMJ98_CH00090
RPHA: 
AMC79_CH00093
RHX: 
AMK02_CH00090
SHZ: 
shn_12220 shn_23650
BRC: 
BCCGELA001_29460
BIC: 
LMTR13_25925
MET: 
M446_3866
HMC: 
HYPMC_3595 HYPMC_3932
MSC: 
BN69_2738
MBRY: 
B1812_11180
RBM: 
TEF_03635
SIL: 
SPO2436 SPO3396
SIT: 
TM1040_0434
RMB: 
K529_007070
RCP: 
RCAP_rcc02885
RHP: 
LPB142_05570
JAN: 
Jann_2849
RDE: 
RD1_0017
RLI: 
RLO149_c003560 RLO149_c039090(sardh)
PDE: 
Pden_4916
PAMI: 
JCM7686_0180
PYE: 
A6J80_21925
PSF: 
PSE_0938 PSE_2975
PGA: 
PGA1_c23300 PGA1_c23390 PGA1_c33110(sardh)
PGL: 
PGA2_c21250 PGA2_c21340 PGA2_c31380(sardh)
PGD: 
Gal_03370
PHP: 
PhaeoP97_02079(sardh_1) PhaeoP97_03221(sardh_2)
OAT: 
OAN307_c43050(sardh2) OAN307_c46300(sardh1)
OAR: 
OA238_c40890(sardh)
OTM: 
OSB_30250(mlr_6)
LMD: 
METH_17920 METH_19105 METH_22720
PTP: 
RCA23_c00690(sardh)
MALG: 
MALG_02870 MALG_03958 MALG_04224
RHC: 
RGUI_2285
SUAM: 
BOO69_16545
TOM: 
BWR18_17925
PABY: 
Ga0080574_TMP412 Ga0080574_TMP433
RMM: 
ROSMUCSMR3_03063(abo)
LVS: 
LOKVESSMR4R_00305(abo)
ATI: 
AL072_19345
PUB: 
SAR11_1221
APC: 
HIMB59_00013500
APM: 
HIMB5_00003950
APB: 
SAR116_1183
MSA: 
Mycsm_02460
MVA: 
Mvan_2290
MRH: 
MycrhN_5693
MCB: 
Mycch_2026
MYE: 
AB431_06845
ICA: 
Intca_0402
MPH: 
MLP_04500
NCA: 
Noca_0642 Noca_2591 Noca_3838
NOA: 
BKM31_27530
KAL: 
KALB_2196
AHM: 
TL08_05290
ABAI: 
IMCC26256_11850
PSL: 
Psta_3136
PSTY: 
BFS30_02915
LUT: 
Lupro_02580
 » show all
Taxonomy
Reference
1  [PMID:15606755]
  Authors
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R
  Title
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism  of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
  Journal
Eur. J. Biochem. 271 (2004) 4677-84.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 
LinkDB All DBs

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