| Entry |
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| Name |
4-methylaminobutanoate oxidase (methylamine-forming);
mao (gene name, ambiguous)
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
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| Sysname |
4-methylaminobutanoate methylamidohydrolase
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| Reaction(IUBMB) |
4-methylaminobutanoate + O2 + H2O = succinate semialdehyde + methylamine + H2O2 [RN: R10101]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme participates in the nicotine degradation pathway of the soil bacterium Arthrobacter nicotinovorans. Has a very weak monoamine oxidase (EC 1.4.3.4) activity with 4-aminobutanoate [1].
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| History |
EC 1.5.3.21 created 2012
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| Pathway |
| Nicotinate and nicotinamide metabolism | | Microbial metabolism in diverse environments |
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| Orthology |
| 4-methylaminobutanoate oxidase (methylamine-forming) |
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| Genes |
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| Reference |
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| Authors |
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R |
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| Title |
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1. |
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| Journal |
Eur. J. Biochem. 271 (2004) 4677-84. |
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| Sequence |
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| Reference |
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| Authors |
Chiribau CB, Mihasan M, Ganas P, Igloi GL, Artenie V, Brandsch R |
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| Title |
Final steps in the catabolism of nicotine. |
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| Journal |
FEBS. J. 273 (2006) 1528-36. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: |
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| LinkDB |
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