| Entry |
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| Name |
spermidine dehydrogenase;
spermidine:(acceptor) oxidoreductase
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| Class |
Oxidoreductases;
Acting on the CH-NH group of donors;
With unknown physiological acceptors
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| Sysname |
spermidine:acceptor oxidoreductase
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| Reaction(IUBMB) |
spermidine + acceptor + H2O = propane-1,3-diamine + 4-aminobutanal + reduced acceptor [RN: R01915]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
propane-1,3-diamine [CPD: C00986];
4-aminobutanal [CPD: C00555];
reduced acceptor [CPD: C00030]
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| Comment |
A flavohemoprotein (FAD). Ferricyanide, 2,6-dichloroindophenol and cytochrome c can act as acceptor. 4-Aminobutanal condenses non-enzymically to 1-pyrroline.
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| History |
EC 1.5.99.6 created 1976
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| Pathway |
| Arginine and proline metabolism | | beta-Alanine metabolism | | Metabolic pathways |
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| Orthology |
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| Genes |
ESA: | | CSK: | | CSZ: | | CSI: | | CSJ: | | CCON: | | CDM: | | CMJ: | | CUI: | | CMW: | | CTU: | | KMI: | | CFD: | | CBRA: | | CIF: | | CNT: | | CEM: | | CEN: | | YRU: | | YRB: | | SPE: | | SRL: | | SRY: | | SPLY: | | SMW: | | SMAR: | | SMAC: | | SLQ: | | SERF: | | SERS: | | SFW: | | SFO: | | EBI: | | EGE: | | HAV: | | OPO: | | PFQ: | | PAE: | | PAEV: | | PAEI: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PAEB: | | PDK: | | PSG: | | PRP: | | PAEP: | | PAER: | | PAEM: | | PAEL: | | PAES: | | PAEU: | | PAEG: | | PAEC: | | PAEO: | | PPG: | | PFS: | | PFW: | | PFF: | | PFX: | | PTV: | | PAZO: | | PPUU: | | PALK: | | SAGA: | | OSG: | | HJA: | | WOC: | | APAC: | | AHA: | | AHY: | | AHD: | | AHR: | | AHP: | | AHJ: | | AHH: | | AHI: | | ASA: | | AVR: | | AVO: | | ASR: | | AAJ: | | GPB: | | NWE: | | KKI: | | CVI: | | CVC: | | RPJ: | | REU: | | REH: | | CNC: | | RME: | | CTI: | | CBW: | | CCUP: | | RGE: | | CJI: | | CJEJ: | | CJEU: | | CJEN: | | CJEI: | | CJY: | | CJW: | | CLA: | | CLR: | | CLM: | | CLQ: | | CLN: | | CLL: | | CIS: | | CVO: | | CPEL: | | CAMR: | | CSM: | | CSF: | | AAK: | | RHZ: | | PSIN: | | SSY: | | GXL: | | KNA: | | KEU: | | ASZ: | | SRO: | | NOA: | | MSV: | | ABA: | | GBA: | |
» show all
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| Reference |
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| Authors |
Tabor CW, Kellogg PD. |
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| Title |
Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens. |
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| Journal |
J. Biol. Chem. 245 (1970) 5424-33. |
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| Reference |
2 |
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| Authors |
Tabor, H. and Tabor, C.W. |
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| Title |
Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase. |
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| Journal |
Adv. Enzymol. Relat. Areas Mol. Biol. 36 (1972) 225-226. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9076-64-6 |
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| LinkDB |
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