| Entry |
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| Name |
NADH oxidase (H2O2-forming);
NOX-1;
H2O2-forming NADH oxidase
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| Class |
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
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| Sysname |
NADH:oxygen oxidoreductase (H2O2-forming)
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| Reaction(IUBMB) |
NADH + H+ + O2 = NAD+ + H2O2 [RN: R07171]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A flavoprotein (FAD). The bacterium Streptococcus mutans contains two distinct NADH oxidases, a H2O2-forming enzyme and a H2O-forming enzyme (cf. EC 1.6.3.4, NADH oxidase (H2O-forming)) [1]. The enzymes from the anaerobic archaea Methanocaldococcus jannaschii [6] and Pyrococcus furiosus [3] also produce low amounts of H2O. Unlike EC 1.6.3.1 (NAD(P)H oxidase) it has no activity towards NADPH.
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| History |
EC 1.6.3.3 created 2013
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| Orthology |
| NADH oxidase (H2O2-forming) |
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| Genes |
MJA: | | MFE: | | MVU: | | MFS: | | MIF: | | MJH: | | MIG: | | MMP: | | MMQ: | | MMX: | | MMZ: | | MMD: | | MMAK: | | MMAO: | | MAE: | | MVN: | | MVO: | | MOK: | | MAC: | | MBA: | | MBY: | | MBW: | | MBAR: | | MBAK: | | MMA: | | MMAZ: | | MMJ: | | MMAC: | | MVC: | | MEK: | | MLS: | | METM: | | MEF: | | MEQ: | | MSJ: | | MSZ: | | MSW: | | MTHE: | | MTHR: | | MHOR: | | MBU: | | MMET: | | MEV: | | MPY: | | MHZ: | | MCJ: | | MPD: | | MEZ: | | RCI: | | MTH: | | MMG: | | METC: | | MWO: | | MST: | | MSI: | | MRU: | | MEB: | | MMIL: | | MEYE: | | MOL: | | MEL: | | MEW: | | METH: | | MFC: | | MFI: | | MCUB: | | MFV: | | MKA: | | TAR: | | MAX: | | MER: | | MEAR: | | MARC: | | PHO: | | PAB: | | PFU: | | PFI: | | PYN: | | PYA: | | PYS: | | PYC: | | TKO: | | TON: | | TGA: | | TSI: | | TBA: | | THE: | | THA: | | THM: | | TLT: | | THS: | | TNU: | | TEU: | | TGY: | | THV: | | TCH: | | TPEP: | | PPAC: | | ACF: | | KCR: | | BARC: | |
» show all
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| Reference |
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| Authors |
Higuchi M, Shimada M, Yamamoto Y, Hayashi T, Koga T, Kamio Y |
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| Title |
Identification of two distinct NADH oxidases corresponding to H2O2-forming oxidase and H2O-forming oxidase induced in Streptococcus mutans. |
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| Journal |
J. Gen. Microbiol. 139 (1993) 2343-51. |
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| Sequence |
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| Reference |
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| Authors |
Ward DE, Donnelly CJ, Mullendore ME, van der Oost J, de Vos WM, Crane EJ 3rd |
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| Title |
The NADH oxidase from Pyrococcus furiosus. Implications for the protection of anaerobic hyperthermophiles against oxidative stress. |
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| Journal |
Eur. J. Biochem. 268 (2001) 5816-23. |
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| Sequence |
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| Reference |
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| Authors |
Kengen SW, van der Oost J, de Vos WM |
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| Title |
Molecular characterization of H2O2-forming NADH oxidases from Archaeoglobus fulgidus. |
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| Journal |
Eur. J. Biochem. 270 (2003) 2885-94. |
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| Sequence |
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| Reference |
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| Authors |
Yang X, Ma K |
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| Title |
Characterization of an exceedingly active NADH oxidase from the anaerobic hyperthermophilic bacterium Thermotoga maritima. |
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| Journal |
J. Bacteriol. 189 (2007) 3312-7. |
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| Sequence |
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| Reference |
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| Authors |
Hirano J, Miyamoto K, Ohta H |
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| Title |
Purification and characterization of thermostable H2O2-forming NADH oxidase from 2-phenylethanol-assimilating Brevibacterium sp. KU1309. |
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| Journal |
Appl. Microbiol. Biotechnol. 80 (2008) 71-8. |
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| Reference |
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| Authors |
Case CL, Rodriguez JR, Mukhopadhyay B |
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| Title |
Characterization of an NADH oxidase of the flavin-dependent disulfide reductase family from Methanocaldococcus jannaschii. |
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| Journal |
Microbiology. 155 (2009) 69-79. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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