| Entry |
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| Name |
renalase;
alphaNAD(P)H oxidase/anomerase (incorrect);
NAD(P)H:oxygen oxidoreductase (H2O2-forming, epimerising) (incorrect)
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| Class |
Oxidoreductases;
Acting on NADH or NADPH;
With oxygen as acceptor
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| Sysname |
dihydro-NAD(P):oxygen oxidoreductase (H2O2-forming)
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| Reaction(IUBMB) |
(1) 1,2-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2 [RN: R11504];
(2) 1,6-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2 [RN: R11505]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Requires FAD. Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta-NAD(P)+. These isomeric forms, generated by nonspecific reduction of beta-NAD(P)+ or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
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| History |
EC 1.6.3.5 created 2014, modified 2015
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | CCAN: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | BIU: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | BACU: | | LVE: | | ECB: | | MYB: | | MYD: | | HAI: | | RSS: | | PALE: | | LAV: | | MDO: | | SHR: | | GGA: | | MGP: | | CJO: | | APLA: | | TGU: | | GFR: | | FAB: | | PHI: | | CCW: | | FPG: | | FCH: | | CLV: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PBI: | | GJA: | | XLA: | | XTR: | | DRE: | | IPU: | | TNG: | | LCO: | | MZE: | | OLA: | | XMA: | | CSEM: | | SASA: | | LCM: | | CMK: | | BFO: | | SPU: | | SKO: | | API: | | DPX: | | LGI: | | CRG: | | OBI: | | NVE: | | ADF: | | HMG: | | TAD: | | AQU: | | SMIN: | | PIF: | | PSOJ: | | EHX: | |
» show all
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| Reference |
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| Authors |
Xu J, Li G, Wang P, Velazquez H, Yao X, Li Y, Wu Y, Peixoto A, Crowley S, Desir GV |
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| Title |
Renalase is a novel, soluble monoamine oxidase that regulates cardiac function and blood pressure. |
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| Journal |
J. Clin. Invest. 115 (2005) 1275-80. |
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| Sequence |
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| Reference |
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| Authors |
Beaupre BA, Hoag MR, Roman J, Forsterling FH, Moran GR |
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| Title |
Metabolic function for human renalase: oxidation of isomeric forms of beta-NAD(P)H that are inhibitory to primary metabolism. |
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| Journal |
Biochemistry. 54 (2015) 795-806. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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