Oxidoreductases;
Acting on a sulfur group of donors;
With oxygen as acceptor

S-prenyl-L-cysteine:oxygen oxidoreductase

an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2 [RN:R07360]

R07360 > R09562

S-prenyl-L-cysteine [CPD:C06751];
O2 [CPD:C00007];
H2O [CPD:C00001]

A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase so it had been classified as EC 4.4.1.18.

EC 1.8.3.5 created 2000 as EC 4.4.1.18, transferred 2002 to EC 1.8.3.5

1  [PMID:9287348]

Zhang L, Tschantz WR, Casey PJ.

Isolation and characterization of a prenylcysteine lyase from bovine brain.

J. Biol. Chem. 272 (1997) 23354-9.

2  [PMID:11078725]

Tschantz WR, Digits JA, Pyun HJ, Coates RM, Casey PJ.

Lysosomal prenylcysteine lyase is a FAD-dependent thioether oxidase.

J. Biol. Chem. 276 (2001) 2321-4.