| Entry |
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| Name |
dimethylsulfoniopropionate demethylase;
dmdA (gene name);
dimethylsulfoniopropionate-dependent demethylase A
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S,S-dimethyl-beta-propiothetin:tetrahydrofolate S-methyltransferase
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| Reaction(IUBMB) |
S,S-dimethyl-beta-propiothetin + tetrahydrofolate = 3-(methylthio)propanoate + 5-methyltetrahydrofolate [RN: R10333]
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| Reaction(KEGG) |
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| Substrate |
S,S-dimethyl-beta-propiothetin [CPD: C04022];
tetrahydrofolate [CPD: C00101]
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| Product |
3-(methylthio)propanoate [CPD: C08276];
5-methyltetrahydrofolate [CPD: C00440]
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| Comment |
The enzyme from the marine bacteria Pelagibacter ubique and Ruegeria pomeroyi are specific towards S,S-dimethyl-beta-propiothetin. They do not demethylate glycine-betaine [1,2].
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| History |
EC 2.1.1.269 created 2013
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| Pathway |
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| Orthology |
| dimethylsulfoniopropionate demethylase |
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| Genes |
HOE: | | SIL: | | SIT: | | JAN: | | RDE: | | RLI: | | DSH: | | PGA: | | OAT: | | OAR: | | OTM: | | LMD: | | RED: | | MALG: | | PUB: | | APC: | | APM: | | APB: | |
» show all
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| Reference |
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| Authors |
Jansen M, Hansen TA |
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| Title |
Tetrahydrofolate serves as a methyl acceptor in the demethylation of dimethylsulfoniopropionate in cell extracts of sulfate-reducing bacteria. |
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| Journal |
Arch. Microbiol. 169 (1998) 84-7. |
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| Reference |
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| Authors |
Reisch CR, Moran MA, Whitman WB |
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| Title |
Dimethylsulfoniopropionate-dependent demethylase (DmdA) from Pelagibacter ubique and Silicibacter pomeroyi. |
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| Journal |
J. Bacteriol. 190 (2008) 8018-24. |
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| Sequence |
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| Reference |
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| Authors |
Schuller DJ, Reisch CR, Moran MA, Whitman WB, Lanzilotta WN |
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| Title |
Structures of dimethylsulfoniopropionate-dependent demethylase from the marine organism Pelagabacter ubique. |
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| Journal |
Protein. Sci. 21 (2012) 289-98. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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