Entry |
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Name |
mRNA m6A methyltransferase;
METTL3 (gene name);
METTL14 (gene name)
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Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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Sysname |
S-adenosyl-L-methionine:adenine in mRNA methyltransferase
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Reaction(IUBMB) |
S-adenosyl-L-methionine + adenine in mRNA = S-adenosyl-L-homocysteine + N6-methyladenine in mRNA [RN: R12011]
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Reaction(KEGG) |
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Substrate |
S-adenosyl-L-methionine [CPD: C00019];
adenine in mRNA [CPD: C21844]
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Product |
S-adenosyl-L-homocysteine [CPD: C00021];
N6-methyladenine in mRNA [CPD: C21845]
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Comment |
This enzyme, found in eukaryotes, methylates adenines in mRNA with the consensus sequence RRACH.
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History |
EC 2.1.1.348 created 2018
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Orthology |
K05925 | mRNA m6A methyltransferase catalytic subunit |
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Genes |
MNP: | 131999573(METTL3) 132002945 |
MLK: | 131813660 131836001(METTL3) |
BTAX: | 128053730(METTL3) 128071349 |
AJM: | 119040151 119054260(METTL3) |
CATA: | 118261342 118261625 |
PMUR: | 107286571(METTL3) 107295391 |
SANH: | 107659734 107664282 |
CCAR: | 109096172 109100071 |
CAUA: | 113052177 113076162 113105868 |
CGIB: | 127961747 128017179 |
MASI: | 127449178 127455230 |
MSAM: | 119896743 119912345(mettl3) |
PRET: | 103476007(mettl3) 103480536 |
SMAU: | 118284182 118291304(mettl3) |
SALP: | 111953381 112070048(mettl3) |
CCLU: | 121573001 123482978(mettl3) |
DSI: | Dsimw501_GD21054(Dsim_GD21054) |
CLON: | 129607196 129617606 |
PPYR: | 116159665 116173594 |
DPX: | DAPPUDRAFT_192406 DAPPUDRAFT_305196 DAPPUDRAFT_66395 |
PMOO: | 119580328 119590051 |
HRO: | HELRODRAFT_121421 HELRODRAFT_68987 HELRODRAFT_79167 |
RPHI: | 132732390 132751102 |
SHX: | MS3_00009168(METTL3_1) |
CSAT: | 104707363 104720582 104737069 |
HSYR: | 120155364 120186807 120199672 |
TPRA: | 123909821 123916667 |
LJA: | Lj0g3v0251359.1(Lj0g3v0251359.1) |
LANG: | 109330921 109360911 |
PAVI: | 110758914 110774093 |
MSYL: | 126600722 126625127 |
CMAX: | 111465197 111498696 |
CMOS: | 111431216 111453835 |
CPEP: | 111800888 111810602 |
CAVE: | 132175174 132176018 |
CANN: | 107839021 107842841 |
SIND: | 105167810 105179105 |
SSPL: | 121796126 121799870 |
PSOM: | 113297700 113301518 |
DOSA: | Os02t0672600-01(Os02g0672600) |
TAES: | 123127974 123137653 123145073 |
PVIR: | 120656777 120712316 |
ZOF: | 121970019 121975132 122007977 122015008 |
SMO: | SELMODRAFT_123364 SELMODRAFT_130187 |
CRE: | CHLRE_06g288100v5 CHLRE_06g295600v5 |
VCN: | VOLCADRAFT_116042 VOLCADRAFT_59216 |
CSL: | COCSUDRAFT_13342 COCSUDRAFT_19144 |
BPG: | Bathy13g02200 Bathy13g02600 |
MPP: | MICPUCDRAFT_51320(JGI:MicpuC2_51320) |
NCS: | NCAS_0B05490(NCAS0B05490) |
NDI: | NDAI_0B02700(NDAI0B02700) |
TPF: | TPHA_0H00330(TPHA0H00330) |
TBL: | TBLA_0F00390(TBLA0F00390) |
TDL: | TDEL_0B04590(TDEL0B04590) |
KAF: | KAFR_0C02930(KAFR0C02930) |
KNG: | KNAG_0G01340(KNAG0G01340) |
CAL: | CAALFM_C201650WA(CaO19.1476) |
CCAC: | CcaHIS019_0210950(IME4) |
ABP: | AGABI1DRAFT73723(AGABI1DRAFT_73723) |
ABV: | AGABI2DRAFT67638(AGABI2DRAFT_67638) |
SCM: | SCHCO_01115185(SCHCODRAFT_01115185) |
TET: | TTHERM_00704040 TTHERM_00962190 |
PTM: | GSPATT00000069001 GSPATT00003428001 GSPATT00015836001 GSPATT00017263001 GSPATT00019450001 GSPATT00027862001 GSPATT00039029001 |
EHX: | EMIHUDRAFT_211665 EMIHUDRAFT_232802 |
TVA: | TVAG_2v0127160 TVAG_2v0543820 TVAG_2v0580320 TVAG_2v0938940 |
» show all
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Reference |
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Authors |
Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C |
Title |
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. |
Journal |
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Sequence |
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Reference |
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Authors |
Wang X, Huang J, Zou T, Yin P |
Title |
Human m(6)A writers: Two subunits, 2 roles. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.1.1.348 |
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LinkDB |
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