| Entry |
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| Name |
UDP-4-amino-4-deoxy-L-arabinose formyltransferase;
UDP-L-Ara4N formyltransferase;
ArnAFT
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| Class |
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
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| Sysname |
10-formyltetrahydrofolate:UDP-4-amino-4-deoxy-beta-L-arabinose N-formyltransferase
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| Reaction(IUBMB) |
10-formyltetrahydrofolate + UDP-4-amino-4-deoxy-beta-L-arabinopyranose = 5,6,7,8-tetrahydrofolate + UDP-4-deoxy-4-formamido-beta-L-arabinopyranose [RN: R07660]
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| Reaction(KEGG) |
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| Substrate |
10-formyltetrahydrofolate [CPD: C00234];
UDP-4-amino-4-deoxy-beta-L-arabinopyranose [CPD: C16153]
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| Product |
5,6,7,8-tetrahydrofolate [CPD: C00101];
UDP-4-deoxy-4-formamido-beta-L-arabinopyranose [CPD: C16154]
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| Comment |
The activity is part of a bifunctional enzyme also performing the reaction of EC 1.1.1.305 [UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)].
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| History |
EC 2.1.2.13 created 2010
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| Pathway |
| Amino sugar and nucleotide sugar metabolism |
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| Orthology |
| UDP-4-amino-4-deoxy-L-arabinose formyltransferase / UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating) |
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| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | ECOL: | | ECOI: | | ECOJ: | | ECOO: | | ECOH: | | ECOS: | | EFE: | | EAL: | | STY: | | STT: | | SEX: | | SENT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SETC: | | SENR: | | SEND: | | SENI: | | SEEN: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEH: | | SHB: | | SENH: | | SEEH: | | SEE: | | SENN: | | SEW: | | SEA: | | SENS: | | SED: | | SEG: | | SEL: | | SEGA: | | SET: | | SENA: | | SENO: | | SENV: | | SENQ: | | SENL: | | SENJ: | | SEEC: | | SEEB: | | SEEP: | | SENB: | | SENE: | | SENC: | | SBG: | | SBZ: | | SBV: | | SFX: | | SFV: | | SFE: | | SFN: | | SFS: | | SFT: | | SSN: | | SBO: | | SBC: | | SDZ: | | SHQ: | | ENT: | | ENC: | | ENO: | | ECLO: | | EEC: | | ENL: | | ECLG: | | ECLE: | | ECLN: | | ECLY: | | ESC: | | KLE: | | EAS: | | EAU: | | EHM: | | EKB: | | ELG: | | ECLS: | | ENR: | | ENX: | | ENF: | | KPN: | | KPU: | | KPM: | | KPP: | | KPK: | | KPH: | | KPZ: | | KPV: | | KPW: | | KPY: | | KPG: | | KPC: | | KPQ: | | KPT: | | KPE: | | KPO: | | KPR: | | KPJ: | | KPI: | | KPA: | | KPS: | | KPX: | | KPB: | | KPNE: | | KPNU: | | KVA: | | KVD: | | KVQ: | | KOX: | | KOE: | | KOY: | | KMI: | | KOK: | | KOC: | | KOM: | | KQU: | | EAE: | | EAR: | | CFD: | | CBRA: | | CAMA: | | CAF: | | CIF: | | HDE: | | SECT: | | SEHC: | | EBT: | | ROR: | | RON: | | CNT: | | CEM: | | CEN: | | CED: | | PGE: | | KSA: | | KOR: | | KRD: | | KCO: | | KIN: | | EBF: | | YPE: | | YPK: | | YPA: | | YPN: | | YPM: | | YPP: | | YPG: | | YPZ: | | YPT: | | YPD: | | YPX: | | YPH: | | YPW: | | YPJ: | | YPV: | | YPL: | | YPS: | | YPO: | | YPI: | | YPY: | | YPB: | | YPQ: | | YPU: | | YPR: | | YPC: | | YPF: | | YEN: | | YEP: | | YEY: | | YEL: | | YEW: | | YET: | | YEF: | | YEE: | | YSI: | | YAL: | | YFR: | | YIN: | | YKR: | | YRO: | | YRU: | | YRB: | | SPE: | | SRR: | | SRL: | | SRY: | | SPLY: | | SRS: | | SRA: | | SMAF: | | SMW: | | SMAR: | | SMAC: | | SLQ: | | SERF: | | SERS: | | SFW: | | SFG: | | SRZ: | | SFO: | | RAH: | | RAQ: | | RAA: | | ECA: | | PATR: | | PATO: | | PCT: | | PCC: | | PCV: | | PWA: | | PPAR: | | PEC: | | PWS: | | SGL: | | SOD: | | PES: | | DDA: | | DDD: | | DZE: | | DDC: | | DZC: | | DSO: | | ETA: | | EPY: | | EPR: | | EAM: | | EAY: | | EBI: | | ERJ: | | EGE: | | WBR: | | WGL: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | PAGG: | | PAGC: | | TCI: | | PLU: | | PAY: | | PTT: | | PMR: | | PMIB: | | PVL: | | XBO: | | XBV: | | XNE: | | XNM: | | XDO: | | XPO: | | XHO: | | PSI: | | PSX: | | PSTA: | | PRG: | | MMK: | | EIC: | | ETR: | | ETD: | | ETE: | | ETC: | | EDW: | | EDL: | | EHO: | | HAV: | | OPO: | | PFQ: | | PAE: | | PAEV: | | PAEI: | | PAU: | | PAP: | | PAG: | | PAF: | | PNC: | | PAEB: | | PDK: | | PSG: | | PRP: | | PAEP: | | PAER: | | PAEM: | | PAEL: | | PAES: | | PAEU: | | PAEG: | | PAEC: | | PAEO: | | PCQ: | | POR: | | PSB: | | PSYR: | | PSP: | | PFL: | | PPRC: | | PPRO: | | PFO: | | PFS: | | PFC: | | PFN: | | PFW: | | PFB: | | PFF: | | PFX: | | PPZ: | | PMAN: | | PTV: | | PCG: | | PVR: | | PAZO: | | PDR: | | PSK: | | PKC: | | PCH: | | PCZ: | | PCP: | | PFZ: | | PPV: | | PSEM: | | PPSY: | | PSOS: | | PANR: | | SSE: | | OME: | | AHA: | | AHY: | | AHD: | | AHR: | | AHP: | | AHJ: | | AHH: | | AHI: | | ASA: | | ASR: | | AAJ: | | BBH: | | BBX: | | CFU: | | CCO: | | DAO: | | DAV: | | PNS: | | MAGQ: | | WIN: | | WIJ: | | SALI: | |
» show all
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| Reference |
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| Authors |
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR. |
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| Title |
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. |
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| Journal |
J. Biol. Chem. 280 (2005) 14154-67. |
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| Sequence |
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| Reference |
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| Authors |
Gatzeva-Topalova PZ, May AP, Sousa MC |
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| Title |
Crystal structure and mechanism of the Escherichia coli ArnA (PmrI) transformylase domain. An enzyme for lipid A modification with 4-amino-4-deoxy-L-arabinose and polymyxin resistance. |
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| Journal |
Biochemistry. 44 (2005) 5328-38. |
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| Sequence |
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| Reference |
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| Authors |
Williams GJ, Breazeale SD, Raetz CR, Naismith JH. |
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| Title |
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis. |
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| Journal |
J. Biol. Chem. 280 (2005) 23000-8. |
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| Sequence |
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| Reference |
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| Authors |
Gatzeva-Topalova PZ, May AP, Sousa MC |
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| Title |
Structure and mechanism of ArnA: conformational change implies ordered dehydrogenase mechanism in key enzyme for polymyxin resistance. |
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| Journal |
Structure. 13 (2005) 929-42. |
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| Sequence |
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| Reference |
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| Authors |
Yan A, Guan Z, Raetz CR |
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| Title |
An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli. |
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| Journal |
J. Biol. Chem. 282 (2007) 36077-89. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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