| Entry |
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| Name |
glutamate formimidoyltransferase;
glutamate formyltransferase;
formiminoglutamic acid transferase;
formiminoglutamic formiminotransferase;
glutamate formiminotransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
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| Sysname |
5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase
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| Reaction(IUBMB) |
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate [RN: R02287]
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| Reaction(KEGG) |
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| Substrate |
5-formimidoyltetrahydrofolate [CPD: C00664];
L-glutamate [CPD: C00025]
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| Product |
tetrahydrofolate [CPD: C00101];
N-formimidoyl-L-glutamate [CPD: C00439]
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| Comment |
A pyridoxal-phosphate protein. Also catalyses formyl transfer from 5-formyltetrahydrofolate to L-glutamate (a reaction formerly listed as EC 2.1.2.6). In eukaryotes, it occurs as a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.
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| History |
EC 2.1.2.5 created 1961, modified 2000 (EC 2.1.2.6 created 1965, incorporated 1984)
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| Pathway |
| Histidine metabolism | | One carbon pool by folate | | Metabolic pathways |
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| Orthology |
| glutamate formiminotransferase | | glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | CCAN: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | BIU: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | BACU: | | LVE: | | ECB: | | MYB: | | MYD: | | HAI: | | RSS: | | LAV: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | CJO: | | APLA: | | TGU: | | GFR: | | FAB: | | PHI: | | CCW: | | FPG: | | FCH: | | CLV: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PBI: | | GJA: | | XLA: | | XTR: | | DRE: | | IPU: | | TRU: | | TNG: | | MZE: | | OLA: | | XMA: | | CSEM: | | SASA: | | LCM: | | CMK: | | BFO: | | CIN: | | SPU: | | SKO: | | DPX: | | ISC: | | HRO: | | LGI: | | CRG: | | OBI: | | NVE: | | ADF: | | AQU: | | DDI: | | DPP: | | DFA: | | BBAY: | | DPS: | | DML: | | DAT: | | DTO: | | SAT: | | HNI: | | FIL: | | FIY: | | SPY: | | SPZ: | | SPYM: | | SPM: | | SPG: | | SPS: | | SPH: | | SPI: | | SPJ: | | SPK: | | SPF: | | SPA: | | SPB: | | STG: | | SOZ: | | STZ: | | STX: | | SPYA: | | SPYH: | | SPYO: | | SSA: | | SGO: | | SDS: | | SDG: | | SDA: | | SDC: | | SDQ: | | STK: | | SCP: | | SCF: | | SOI: | | SIK: | | SIQ: | | SIO: | | SIZ: | | SIG: | | SIP: | | VTE: | | ASAN: | | CTC: | | CTET: | | CLJ: | | CAH: | | CSQ: | | CACE: | | CCK: | | CEU: | | AMT: | | AOE: | | GFE: | | BYL: | | CSO: | | EAC: | | CST: | | STH: | | DOR: | | DAI: | | DMI: | | OVA: | | SAY: | | SAP: | | CAD: | | TTE: | | TEX: | | THX: | | TPD: | | TIT: | | TMT: | | TBO: | | TWI: | | CHY: | | TEP: | | TAE: | | TPZ: | | TOC: | | TTM: | | TTO: | | TXY: | | TSH: | | CPO: | | NTH: | | HPK: | | AAR: | | PED: | | PUF: | | PFT: | | AFN: | | AIN: | | ERL: | | LPIL: | | MBJ: | | CWO: | | AFO: | | ABAI: | | GLJ: | | HAU: | | ATM: | | ABAO: | | ABAT: | | CAP: | | CCZ: | | FGI: | | TTR: | | TDE: | | TPED: | | TPK: | | ABA: | | ACA: | | ACM: | | GMA: | | TSA: | | TRS: | | SUS: | | CTM: | | ABAC: | | EMI: | | FNU: | | FNC: | | FNT: | | FUS: | | FNE: | | FHW: | | TAI: | | ACO: | | TLI: | | AMO: | | CPOR: | | GAU: | | GBA: | | BTH: | | BTHO: | | BFR: | | BFS: | | BFG: | | BFB: | | BVU: | | BHL: | | BXY: | | BDO: | | BDH: | | BOA: | | BCEL: | | BACC: | | PGI: | | PGN: | | PGT: | | PAH: | | PBT: | | PDI: | | TFO: | | TOH: | | PSAC: | | OSP: | | PMZ: | | PDN: | | PIT: | | PFUS: | | PEO: | | AFD: | | ASH: | | RBC: | | DORI: | | BLQ: | | HHY: | | SGN: | | MUP: | | FLI: | | LUT: | | LUL: | | OHO: | | BBAU: | | IAL: | | MRO: | | CACI: | | TMA: | | TMM: | | TMI: | | TMW: | | TMQ: | | TMX: | | TPT: | | TRQ: | | TNA: | | TNP: | | THQ: | | THZ: | | THR: | | TLE: | | TTA: | | PHY: | | TME: | | TAF: | | THP: | | THER: | | FNO: | | FPE: | | FIA: | | PMO: | | DTN: | | KOL: | | KPF: | | MPG: | | CEX: | | CABY: | | NDE: | | NMV: | | NIO: | | TAC: | | TVO: | | PTO: | | FAC: | | FAI: | | CDIV: | | ABI: | | ACF: | | BARC: | | LOKI: | |
» show all
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| Reference |
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| Authors |
MILLER A, WAELSCH H. |
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| Title |
Formimino transfer from formamidinoglutaric acid to tetrahydrofolic acid. |
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| Journal |
J. Biol. Chem. 228 (1957) 397-417. |
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| Reference |
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| Authors |
SILVERMAN M, KERESZTESY JC, KOVAL GJ, GARDINER RC. |
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| Title |
Citrovorum factor and the synthesis of formylglutamic acid. |
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| Journal |
J. Biol. Chem. 226 (1957) 83-94. |
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| Reference |
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| Authors |
TABOR H, WYNGARDEN L. |
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| Title |
The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid. |
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| Journal |
J. Biol. Chem. 234 (1959) 1830-46. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9032-83-1 |
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| LinkDB |
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