| Entry |
|
|---|
| Name |
deoxycytidylate 5-hydroxymethyltransferase;
dCMP hydroxymethylase;
d-cytidine 5'-monophosphate hydroxymethylase;
deoxyCMP hydroxymethylase;
deoxycytidylate hydroxymethylase;
deoxycytidylic hydroxymethylase
|
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
 |
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| Sysname |
5,10-methylenetetrahydrofolate:deoxycytidylate 5-hydroxymethyltransferase
|
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| Reaction(IUBMB) |
5,10-methylenetetrahydrofolate + H2O + deoxycytidylate = tetrahydrofolate + 5-hydroxymethyldeoxycytidylate [RN: R01669]
|
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| Reaction(KEGG) |
|
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| Substrate |
5,10-methylenetetrahydrofolate [CPD: C00143];
H2O [CPD: C00001];
deoxycytidylate [CPD: C00239]
|
|---|
| Product |
tetrahydrofolate [CPD: C00101];
5-hydroxymethyldeoxycytidylate [CPD: C03997]
|
|---|
| History |
EC 2.1.2.8 created 1972
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| Pathway |
| Pyrimidine metabolism | | One carbon pool by folate |
|
|---|
| Orthology |
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| Reference |
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| Authors |
MATHEWS CK, BROWN F, COHEN SS. |
|---|
| Title |
VIRUS-INDUCED ACQUISITION OF METABOLIC FUNCTION. VII. BIOSYNTHESIS DE NOVO OF DEOXYCYTIDYLATE HYDROXYMETHYLASE. |
|---|
| Journal |
J. Biol. Chem. 239 (1964) 2957-63. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9012-68-4 |
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| LinkDB |
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