| Entry |
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| Name |
2-hydroxy-3-oxoadipate synthase;
2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating);
alpha-ketoglutaric-glyoxylic carboligase;
oxoglutarate: glyoxylate carboligase
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| Class |
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
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| Sysname |
2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)
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| Reaction(IUBMB) |
2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 [RN: R00474]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The bacterial enzyme requires thiamine diphosphate. The product decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate.
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| History |
EC 2.2.1.5 created 1972 as EC 4.1.3.15, transferred 2002 to EC 2.2.1.5
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| Pathway |
| Glyoxylate and dicarboxylate metabolism |
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| Reference |
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| Authors |
Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW. |
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| Title |
Carboligase activity of alpha-ketoglutarate dehydrogenase. |
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| Journal |
Biochemistry. 9 (1970) 1148-53. |
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| Reference |
|
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| Authors |
Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW. |
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| Title |
Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase. |
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| Journal |
Biochemistry. 7 (1968) 333-7. |
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| Reference |
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| Authors |
Stewart PR, Quayle JR. |
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| Title |
The synergistic decarboxylation of glyoxylate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria. |
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| Journal |
Biochem. J. 102 (1967) 885-897. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9054-72-2 |
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| LinkDB |
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