KEGG ENZYME: 2.3.1.169

ENZYME: 2.3.1.169

Entry

EC 2.3.1.169 Enzyme

Name

CO-methylating acetyl-CoA synthase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:corrinoid protein O-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] [RN:R08433]

Reaction(KEGG)

R08433;
(other) R09317 R10243

Substrate

acetyl-CoA [CPD:C00024];
[Co(I) corrinoid Fe-S protein]

Product

CO [CPD:C00237];
CoA [CPD:C00010];
[methyl-Co(III) corrinoid Fe-S protein]

Comment

Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2.

History

EC 2.3.1.169 created 2003, modified 2015

Pathway

ec00720	Carbon fixation pathways in prokaryotes
ec01120	Microbial metabolism in diverse environments

Orthology

K14138

acetyl-CoA synthase

Genes

DAK:	DaAHT2_0825
DSF:	UWK_03162
DOL:	Dole_3184
DML:	Dmul_30850(cdhC)
DAL:	Dalk_0681
DAT:	HRM2_16660(cdhC)
DTO:	TOL2_C11810(cdhC)
DAO:	Desac_1967
DTI:	Desti_0231
SFU:	Sfum_2565
DBR:	Deba_0240
CLJ:	CLJU_c37550
CAH:	CAETHG_1608
CSQ:	CSCA_4551
CACE:	CACET_c10320(acsB)
CCK:	Ccar_18785
AMT:	Amet_2028
GFE:	Gferi_06315
BYL:	A4V09_05460
CDF:	CD630_07280
PDC:	CDIF630_00844(cdhC)
CDC:	CD196_0674
CDL:	CDR20291_0655
PDF:	CD630DERM_07280
CST:	CLOST_1171
DSY:	DSY1652
DHD:	Dhaf_2797
DDH:	Desde_2255
DDL:	Desdi_1921
DMT:	DESME_07330
DAE:	Dtox_1271 Dtox_3781
DKU:	Desku_1491 Desku_2149
DGI:	Desgi_0523 Desgi_1186 Desgi_2051
DAU:	Daud_0871
TJR:	TherJR_1158
DOR:	Desor_3273
DAI:	Desaci_2974
DMI:	Desmer_2535
DED:	DHBDCA_p224
DEC:	DCF50_p284
DRS:	DEHRE_00705
ELM:	ELI_3601
AWO:	Awo_c10760(acsB1) Awo_c33680(acsB2)
TKI:	TKV_c19820(acsB)
CHY:	CHY_1222(acsB)
TEP:	TepRe1_0561
TAE:	TepiRe1_0613
MTA:	Moth_1202
ADG:	Adeg_0336
TPZ:	Tph_c15170(acsA)
TOC:	Toce_0813
AAR:	Acear_1304
DET:	DET0666 DET0700
DEH:	cbdbA652(codH)
DEB:	DehaBAV1_0635
DEV:	DhcVS_604(cdhC)
DEG:	DehalGT_0597
DMC:	btf_622(acsB)
DMD:	dcmb_668(acsB)
DMG:	GY50_0591(cdhC)
DMX:	X792_03230
DMY:	X793_02975
DMZ:	X794_02725
DUC:	UCH007_05840(acsB)
DLY:	Dehly_0817
DEW:	DGWBC_1386
DFO:	Dform_00887(acsB) Dform_00914(acsB)
TAZ:	TREAZ_1648
TPI:	TREPR_3067
TYE:	THEYE_A1470
TID:	Thein_2183
TOP:	TOPB45_0394
TCM:	HL41_07625
CTHI:	THC_1762
MEMA:	MMAB1_3162
MER:	MMINT_19140

» show all

Reference

1 [PMID:2984190]

Authors

Ragsdale SW, Wood HG.

Title

Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.

Journal

J. Biol. Chem. 260 (1985) 3970-7.

Reference

2 [PMID:12386327]

Authors

Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL.

Title

A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.

Journal

Science. 298 (2002) 567-72.

Sequence

[mta:Moth_1202]