| Entry |
|
|---|
| Name |
chrysanthemyl diphosphate synthase;
CPPase |
|---|
| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only
sub-subclass identified to date)
 |
|---|
| Sysname |
dimethylallyl-diphosphate:dimethylallyl-diphosphate
dimethylallyltransferase (chrysanthemyl-diphosphate-forming) |
|---|
| Reaction(IUBMB) |
2 dimethylallyl diphosphate = diphosphate + chrysanthemyl
diphosphate [RN:R08948] |
|---|
| Reaction(KEGG) |
R08948
 |
|---|
| Substrate |
dimethylallyl diphosphate [CPD:C00235] |
|---|
| Product |
diphosphate [CPD:C00013];
chrysanthemyl diphosphate [CPD:C18051] |
|---|
| Comment |
Requires a divalent metal ion for activity, with Mg2+ being better
than Mn2+ [1]. Chrysanthemyl diphosphate is a monoterpene with a
non-head-to-tail linkage. It is unlike most monoterpenoids, which
are derived from geranyl diphosphate and have isoprene units that
are linked head-to-tail. The mechanism of its formation is similar
to that of the early steps of squalene and phytoene biosynthesis.
Chrysanthemyl diphosphate is the precursor of chrysanthemic acid,
the acid half of the pyrethroid insecticides found in
chrysanthemums. |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:11287653]
Rivera SB, Swedlund BD, King GJ, Bell RN, Hussey CE Jr,
Shattuck-Eidens DM, Wrobel WM, Peiser GD, Poulter CD.
Chrysanthemyl diphosphate synthase: isolation of the gene and
characterization of the recombinant non-head-to-tail monoterpene
synthase from Chrysanthemum cinerariaefolium.
Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 4373-8.
Chrysanthemum cinerariaefolium |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:12783539]
Erickson HK, Poulter CD.
Chrysanthemyl diphosphate synthase. The relationship among chain
elongation, branching, and cyclopropanation reactions in the
isoprenoid biosynthetic pathway.
J. Am. Chem. Soc. 125 (2003) 6886-8. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 2.5.1.67
IUBMB Enzyme Nomenclature: 2.5.1.67
ExPASy - ENZYME nomenclature database: 2.5.1.67
BRENDA, the Enzyme Database: 2.5.1.67 |
|---|
