KEGG   ENZYME: 2.6.1.77Help
Entry
EC 2.6.1.77                 Enzyme                                 

Name
taurine---pyruvate aminotransferase;
Tpa
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
taurine:pyruvate aminotransferase
Reaction(IUBMB)
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde [RN:R05652]
Reaction(KEGG)
Substrate
taurine [CPD:C00245];
pyruvate [CPD:C00022]
Product
L-alanine [CPD:C00041];
2-sulfoacetaldehyde [CPD:C00593]
Comment
The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.
History
EC 2.6.1.77 created 2003
Pathway
Taurine and hypotaurine metabolism
Metabolic pathways
Orthology
K03851  
taurine-pyruvate aminotransferase
Genes
VEJ: 
PIN: 
MPC: 
BPE: 
BPC: 
BPER: 
BPA: 
BPAR: 
BBR: 
BBM: 
BBH: 
DVM: 
DDS: 
DPS: 
SIL: 
SPO0673(tpa)
SIT: 
RSP: 
RSP_0943(yhxA)
RSH: 
RSQ: 
RSK: 
RCP: 
RDE: 
RLI: 
PDE: 
PAMI: 
DSH: 
KVU: 
KVL: 
KVU_0494(yhxA) KVU_0941(tpa)
PGA: 
PGL: 
PGD: 
OAT: 
OAR: 
LMD: 
PTP: 
GXL: 
TMO: 
PBD: 
DDL: 
DRU: 
 » show all
Taxonomy
Reference
1  [PMID:11082195]
  Authors
Laue H, Cook AM.
  Title
Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia.
  Journal
Eur. J. Biochem. 267 (2000) 6841-8.
  Sequence
[up:Q9APM5]
Reference
2  [PMID:12471498]
  Authors
Cook AM, Denger K.
  Title
Dissimilation of the C2 sulfonates.
  Journal
Arch. Microbiol. 179 (2002) 1-6.
Reference
3  [PMID:11728723]
  Authors
Masepohl B, Fuhrer F, Klipp W.
  Title
Genetic analysis of a Rhodobacter capsulatus gene region involved in utilization of taurine as a sulfur source.
  Journal
FEMS. Microbiol. Lett. 205 (2001) 105-11.
Reference
4  [PMID:23603744]
  Authors
Felux AK, Denger K, Weiss M, Cook AM, Schleheck D
  Title
Paracoccus denitrificans PD1222 utilizes hypotaurine via transamination followed  by spontaneous desulfination to yield acetaldehyde and, finally, acetate for growth.
  Journal
J. Bacteriol. 195 (2013) 2921-30.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
51901-18-9
LinkDB All DBs

DBGET integrated database retrieval system