KEGG   ENZYME: 2.6.1.77Help
Entry
EC 2.6.1.77                 Enzyme                                 

Name
taurine---pyruvate aminotransferase;
Tpa
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
taurine:pyruvate aminotransferase
Reaction(IUBMB)
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde [RN:R05652]
Reaction(KEGG)
Substrate
taurine [CPD:C00245];
pyruvate [CPD:C00022]
Product
L-alanine [CPD:C00041];
2-sulfoacetaldehyde [CPD:C00593]
Comment
The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.
History
EC 2.6.1.77 created 2003
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K03851  taurine-pyruvate aminotransferase
Genes
VNA: PN96_16085
VEJ: VEJY3_24191
PGB: H744_1c1564
PCQ: PcP3B5_40420(tpa_3)
COLW: A3Q33_11510
PIN: Ping_0051
WOC: BA177_02200
GAI: IMCC3135_11690(tpa)
HHH: CLM76_04195
MPC: Mar181_2033
BPE: BP0721
BPC: BPTD_0724
BPER: BN118_0083
BPET: B1917_3102
BPEU: Q425_33090
BPA: BPP3675
BPAR: BN117_1002
BBR: BB4110
DVM: DvMF_0516
DDS: Ddes_0218
DPS: DP0541
MAQU: Maq22A_c21465(bioA)
SIL: SPO0673(tpa)
RSP: RSP_0943(yhxA)
RCP: RCAP_rcc02240(tpa)
RDE: RD1_0981(tpa)
RLI: RLO149_c001900(tpa)
PDE: Pden_4273
DSH: Dshi_2042(tpa)
KVU: EIO_1453
KVL: KVU_0494(yhxA) KVU_0941(tpa)
KRO: BVG79_01142(tpa)
PGA: PGA1_c28770(tpa)
PGL: PGA2_c26710(tpa)
PGD: Gal_00552
PHP: PhaeoP97_00629(tpa)
PPIC: PhaeoP14_02649(tpa)
OAT: OAN307_c06270(tpa)
OAR: OA238_c35800(tpa)
OTM: OSB_27890(tpa_2)
PTP: RCA23_c01520(tpa)
CID: P73_3057
MALG: MALG_00569
RHC: RGUI_0795
SPSE: SULPSESMR1_03483(tpa)
RMM: ROSMUCSMR3_02376(tpa)
TMO: TMO_c0442
 » show all
Taxonomy
Reference
1  [PMID:11082195]
  Authors
Laue H, Cook AM.
  Title
Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia.
  Journal
Eur. J. Biochem. 267 (2000) 6841-8.
  Sequence
Reference
2  [PMID:12471498]
  Authors
Cook AM, Denger K.
  Title
Dissimilation of the C2 sulfonates.
  Journal
Arch. Microbiol. 179 (2002) 1-6.
Reference
3  [PMID:11728723]
  Authors
Masepohl B, Fuhrer F, Klipp W.
  Title
Genetic analysis of a Rhodobacter capsulatus gene region involved in utilization of taurine as a sulfur source.
  Journal
FEMS. Microbiol. Lett. 205 (2001) 105-11.
Reference
4  [PMID:23603744]
  Authors
Felux AK, Denger K, Weiss M, Cook AM, Schleheck D
  Title
Paracoccus denitrificans PD1222 utilizes hypotaurine via transamination followed  by spontaneous desulfination to yield acetaldehyde and, finally, acetate for growth.
  Journal
J. Bacteriol. 195 (2013) 2921-30.
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.77
IUBMB Enzyme Nomenclature: 2.6.1.77
ExPASy - ENZYME nomenclature database: 2.6.1.77
BRENDA, the Enzyme Database: 2.6.1.77
CAS: 51901-18-9
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