KEGG ENZYME: 3.3.2.1

ENZYME: 3.3.2.1

Entry

EC 3.3.2.1 Enzyme

Name

isochorismatase;
2,3-dihydro-2,3-dihydroxybenzoate synthase;
2,3-dihydroxy-2,3-dihydrobenzoate synthase;
2,3-dihydroxy-2,3-dihydrobenzoic synthase

Class

Hydrolases;
Acting on ether bonds;
Ether hydrolases

Sysname

isochorismate pyruvate-hydrolase

Reaction(IUBMB)

isochorismate + H2O = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate [RN:R03037]

Reaction(KEGG)

R03037

Substrate

isochorismate [CPD:C00885];
H2O [CPD:C00001]

Product

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate;
pyruvate [CPD:C00022]

Comment

The enzyme is involved in the biosynthesis of several siderophores, such as 2,3-dihydroxybenzoylglycine, enterobactin, bacillibactin, and vibriobactin.

History

EC 3.3.2.1 created 1972

Pathway

ec01053	Biosynthesis of siderophore group nonribosomal peptides
ec01110	Biosynthesis of secondary metabolites
ec01130	Biosynthesis of antibiotics

Orthology

K01252

bifunctional isochorismate lyase / aryl carrier protein

Genes

ECO:	b0595(entB)
ECJ:	JW0587(entB)
ECD:	ECDH10B_0555(entB) ECDH10B_0663(entB)
EBW:	BWG_0468(entB)
ECOK:	ECMDS42_0456(entB)
ECE:	Z0737(entB)
ECS:	ECs0634
ECF:	ECH74115_0680(entB)
ETW:	ECSP_0649(entB)
ELX:	CDCO157_0619
EOJ:	ECO26_0670(entB)
EOI:	ECO111_0625(entB)
EOH:	ECO103_0603(entB)
ECG:	E2348C_0497(entB)
EOK:	G2583_0758(entB)
ELR:	ECO55CA74_03715
ECC:	c0682(entB)
ECP:	ECP_0627
ECI:	UTI89_C0597(entB)
ECV:	APECO1_1454(entB)
ECX:	EcHS_A0646(entB)
ECW:	EcE24377A_0615(entB)
ECM:	EcSMS35_0615(entB)
ECY:	ECSE_0662
ECR:	ECIAI1_0579(entB)
ECQ:	ECED1_0592(entB)
ECK:	EC55989_0587(entB)
ECT:	ECIAI39_0572(entB)
EOC:	CE10_0595(entB)
EUM:	ECUMN_0689(entB)
ECZ:	ECS88_0634(entB)
ELO:	EC042_0633(entB)
ELN:	NRG857_02700
ELH:	ETEC_0625
ESE:	ECSF_0536
ESO:	O3O_06680
ESM:	O3M_18595
ESL:	O3K_18615
ECL:	EcolC_3049
EBR:	ECB_00562(entB)
EBD:	ECBD_3059
EKO:	EKO11_3270
EKF:	KO11_20690(entB)
EAB:	ECABU_c06450(entB)
EDH:	EcDH1_3031
EDJ:	ECDH1ME8569_0565(entB)
EIH:	ECOK1_0607(entB)
ENA:	ECNA114_0538(entB)
ELU:	UM146_14530
EUN:	UMNK88_628(entB)
ELW:	ECW_m0650(entB)
ELL:	WFL_03230(entB)
ELC:	i14_0656(entB)
ELD:	i02_0656(entB)
ELP:	P12B_c0580(entB)
EBL:	ECD_00562(entB)
EBE:	B21_00551(entB)
ELF:	LF82_0564(entB)
ECOA:	APECO78_06555
ECOL:	LY180_03225
ECOI:	ECOPMV1_00613(entB)
ECOJ:	P423_02920
ECOO:	ECRM13514_0617(entB)
ECOH:	ECRM13516_0561(entB)
ECOS:	EC958_0715(entB)
EFE:	EFER_2499(entB)
EAL:	EAKF1_ch0866c(entB)
STY:	STY0641(entB)
STT:	t2271(entB)
SEX:	STBHUCCB_24050
SENT:	TY21A_11520
STM:	STM0597(entB)
SEO:	STM14_0695(entB)
SEV:	STMMW_06621
SEY:	SL1344_0585(entB)
SEM:	STMDT12_C06590
SEJ:	STMUK_0602(entB)
SEB:	STM474_0617(entB)
SEF:	UMN798_0646(entB)
SETU:	STU288_11390
SETC:	CFSAN001921_14050
SENR:	STMDT2_05881(entB)
SEND:	DT104_06251(entB)
SENI:	CY43_03270
SEEN:	SE451236_09005
SPT:	SPA2137(entB)
SEK:	SSPA1987
SPQ:	SPAB_02966
SEI:	SPC_0609(entB)
SEC:	SCH_0628(entB)
SEH:	SeHA_C0709(entB)
SHB:	SU5_01287
SENH:	CFSAN002069_05860
SEEH:	SEEH1578_12415
SEE:	SNSL254_A0650(entB)
SENN:	SN31241_16010
SEW:	SeSA_A0755(entB)
SEA:	SeAg_B0636(entB)
SENS:	Q786_02915
SED:	SeD_A0693
SEG:	SG0601(entB)
SEL:	SPUL_2369(entB)
SEGA:	SPUCDC_2355(entB)
SET:	SEN0566(entB)
SENA:	AU38_02895
SENO:	AU37_02890
SENV:	AU39_02895
SENQ:	AU40_03185
SENL:	IY59_02950
SENJ:	CFSAN001992_08345
SEEC:	CFSAN002050_09595
SEEB:	SEEB0189_016295
SEEP:	I137_10805
SENB:	BN855_5890
SENE:	IA1_03130
SENC:	SEET0819_09950
SES:	SARI_02339
SBG:	SBG_0505(entB)
SBZ:	A464_570
SBV:	N643_02510
SFL:	SF0509(entB)
SFX:	S0515(entB)
SFV:	SFV_0543(entB)
SFE:	SFxv_0562(entB)
SFN:	SFy_0663
SFS:	SFyv_0702
SFT:	NCTC1_00531(entB)
SSN:	SSON_0546(entB)
SBO:	SBO_0456(entB)
SBC:	SbBS512_E0497(entB)
SDY:	SDY_0526(entB)
SDZ:	Asd1617_00681
SHQ:	A0259_06655
ENT:	Ent638_1127
ENC:	ECL_03106
ENO:	ECENHK_06105
ECLO:	ENC_21380
EEC:	EcWSU1_01170(entB)
ENL:	A3UG_06030
ECLG:	EC036_11550
ECLE:	ECNIH2_06690
ECLN:	ECNIH4_16600
ECLI:	ECNIH5_05810
ECLX:	LI66_05680
ECLY:	LI62_06590
ECLZ:	LI64_06185
ECLA:	ECNIH3_05820
ECLC:	ECR091_05800
ESC:	Entcl_3200
KLE:	AO703_06245
EAS:	Entas_1093
EAU:	DI57_12840
EHM:	AB284_19200
EKB:	BFV64_05745
ELG:	BH714_01965
EXF:	BFV63_05810
ECLS:	LI67_006780
ENR:	H650_21620
ENX:	NI40_005525
ENF:	AKI40_3691
ESA:	ESA_00798
CSK:	ES15_1067(entB)
CSZ:	CSSP291_03915
CSI:	P262_01543
CSJ:	CSK29544_02010
CCON:	AFK62_14470
CDM:	AFK67_14880
CMJ:	AFK66_004940
CUI:	AFK65_14350
CMW:	AFK63_03920
CTU:	CTU_30450(entB)
KPN:	KPN_00613(entB)
KPU:	KP1_1559(entB)
KPM:	KPHS_14480
KPP:	A79E_3627
KPK:	A593_17525
KPH:	KPNIH24_21565
KPZ:	KPNIH27_06710
KPV:	KPNIH29_07400
KPW:	KPNIH30_07440
KPY:	KPNIH31_07315
KPG:	KPNIH32_07545
KPC:	KPNIH10_07225
KPQ:	KPR0928_07135
KPT:	VK055_1923(entB)
KPE:	KPK_3965(entB)
KPO:	KPN2242_05925
KPJ:	N559_3714
KPI:	D364_03215
KPA:	KPNJ1_03969
KPS:	KPNJ2_04013
KPX:	PMK1_02944(entB)
KPB:	FH42_24095
KPNE:	KU54_019215
KPNU:	LI86_19040
KVA:	Kvar_3755
KVD:	KR75_14980
KVQ:	SP68_21610
KOX:	KOX_13960
KOE:	A225_1610
KOY:	J415_23580
KOK:	KONIH1_07905
KOC:	AB185_28215
KOM:	HR38_12700
KQU:	AVR78_11730
EAE:	EAE_13660
EAR:	CCG31239
CKO:	CKO_02566
CRO:	ROD_06041(entB)
CFD:	CFNIH1_13075
CBRA:	A6J81_10120
CAMA:	F384_02630
CAF:	AL524_19660
CIF:	AL515_07630
CFAR:	CI104_07340
EBT:	EBL_c13930(entB)
ROR:	RORB6_12010
RON:	TE10_08890
CED:	LH89_19400
PGE:	LG71_21960
KSA:	C813_08860
KOR:	AWR26_18285
KRD:	A3780_05995
KCO:	BWI95_11755
KIN:	AB182_18170
LAX:	APT61_16620
LAZ:	A8A57_05925
EBF:	D782_3242
PSTS:	E05_19440
YEL:	LC20_00735(entB)
YFR:	AW19_2615(entB)
YKR:	CH54_3173
YRU:	BD65_1339(entB)
YRB:	UGYR_07420
SPE:	Spro_3419
SRR:	SerAS9_3612
SRL:	SOD_c33400(entB)
SRY:	M621_18165
SPLY:	Q5A_018100(entB)
SRS:	SerAS12_3613
SRA:	SerAS13_3614
SMAF:	D781_3205
SMW:	SMWW4_v1c03170(entB)
SMAR:	SM39_4674(entB)
SMAC:	SMDB11_4415(entB)
SLQ:	M495_17620
SERF:	L085_02470
SERS:	SERRSCBI_01445
SFW:	WN53_26465
SFG:	AV650_22550
SRZ:	AXX16_1866
SFO:	Z042_04150
ECA:	ECA0479(entB)
PATR:	EV46_02485
PATO:	GZ59_04960(entB)
PCT:	PC1_0464
PCC:	PCC21_004950
PCV:	BCS7_02465
PWA:	Pecwa_3737
PPAR:	A8F97_22805
PEC:	W5S_3879
PWS:	A7983_03730
DDA:	Dd703_1488 Dd703_3075
DDD:	Dda3937_02432(cbsB)
DZE:	Dd1591_1316
DDC:	Dd586_2819
DZC:	W909_13800
DSO:	A4U42_02260
EGE:	EM595_0482(entB)
PVA:	Pvag_3655(entB)
PAO:	Pat9b_0483
KLN:	LH22_19840
PAGG:	AL522_06405
PAGC:	BEE12_09185
TCI:	A7K98_01160
PLU:	plu2728(entB)
PAY:	PAU_00894(phbB)
PTT:	VY86_02560
XBO:	XBJ1_1435(entB) XBJ1_2612(entB)
XBV:	XBW1_1506(entB)
XPO:	XPG1_1080(entB) XPG1_2292
XHO:	A9255_10775 A9255_12820
SML:	Smlt2820
SMT:	Smal_2274
BUJ:	BurJV3_2332
SMZ:	SMD_2466(entB)
SRH:	BAY15_2133
SLM:	BIZ42_00685
STEN:	CCR98_12105
LAB:	LA76x_2595(dhbB)
LAQ:	GLA29479_1047(dhbB)
LCP:	LC55x_2737(dhbB)
LEZ:	GLE_2622
LEM:	LEN_2414
VCH:	VC0771
VCF:	IR04_09255
VCE:	Vch1786_I0277(vibB)
VCJ:	VCD_003555
VCO:	VC0395_A0300(vibB)
VCR:	VC395_0788(vibB)
VCM:	VCM66_0729(vibB)
VCI:	O3Y_03590
VCL:	VCLMA_A0683
VCQ:	EN18_07245
VCS:	MS6_0583
VCX:	VAA049_2926(dhbB)
VCZ:	VAB027_1427(dhbB)
VVU:	VV2_0838
VVY:	VVA1304
VVM:	VVMO6_04206
VVL:	VV93_v1c42230
VHA:	VIBHAR_01400 VIBHAR_02097
VCA:	M892_02805 M892_06045
VAG:	N646_0827
VHR:	AL538_14160
VNA:	PN96_09095
VOW:	A9237_03870
VEJ:	VEJY3_04080
VFU:	vfu_A01467
VNI:	VIBNI_B0615(vibB)
VAN:	VAA_02395
LAG:	N175_10465 N175_19250
VAU:	VANGNB10_67p011(angB_G) VANGNB10_cI0893(vabB)
VFL:	AL536_11425
VGA:	BSQ33_15370
PPR:	PBPRB1822(BRA0014)
PMOS:	O165_009595
POR:	APT59_14255
PSJ:	PSJM300_09865
PBM:	CL52_05675
PSEC:	CCOS191_2633(dhbB)
AVN:	Avin_21200(entB)
AVL:	AvCA_21200(entB)
AVD:	AvCA6_21200(entB)
ACB:	A1S_2380 A1S_2580
ABY:	ABAYE1097(basF)
ABC:	ACICU_02577(basF)
ABN:	AB57_2809
ABB:	ABBFA_001063
ABX:	ABK1_2696
ABZ:	ABZJ_02771
ABR:	ABTJ_01136
ABD:	ABTW07_2826(basF)
ABH:	M3Q_2844
ABAD:	ABD1_23750(basF)
ABJ:	BJAB07104_02735
ABAB:	BJAB0715_02783
ABAJ:	BJAB0868_02617
ABAZ:	P795_5025
ABK:	LX00_13115
ABAU:	IX87_08650
ABAA:	IX88_15195
ABW:	BL01_04700
ABAL:	ABLAC_10810
ACC:	BDGL_001868(basF)
ANO:	RR32_09150
ACD:	AOLE_09890
ACI:	ACIAD2775(entB)
ACW:	A0J50_05175
ASOL:	BEN76_08880
ALA:	BFG52_10830
PPHE:	PP2015_1092
PRR:	AT705_10855
PLZ:	S4054249_19785
PPIS:	B1L02_00665
SDE:	Sde_3398
TTU:	TERTU_4061(dhbB)
MTHD:	A3224_14750
HCH:	HCH_06565
HEL:	HELO_2837(entB)
HAA:	A5892_08000
KUS:	B9G99_09220
KMA:	B9H00_05630
MMW:	Mmwyl1_1623 Mmwyl1_1633
MME:	Marme_2828
MPC:	Mar181_2163
GSN:	YC6258_02767
AHA:	AHA_2477
AHY:	AHML_13145
AHD:	AI20_07025
AHR:	V428_13605
AHP:	V429_13625
AHJ:	V469_09495
AHH:	RY45_12870
AHI:	VU14_00740 VU14_09430
ASA:	ASA_1840(entB)
AVR:	B565_2635
AVO:	AMS64_15945
AMED:	B224_1644 B224_1648
ASR:	WL1483_37(entB)
AAJ:	BOQ57_12690
AEO:	O23A_p1129
OCM:	CBP12_05485
SALV:	SALWKB2_2018
CVI:	CV_1483(entB)
CVC:	BKX93_20565
JEU:	BJP62_04335
BAM:	Bamb_1688
BPYR:	ABD05_14940
BUB:	BW23_192
BMEC:	WJ16_09000
BSTG:	WT74_07870
CDN:	BN940_00306
AFA:	UZ73_09205
PHN:	PAEH1_09555
CSER:	CCO03_15460
JAG:	GJA_3092
JAB:	VN23_17110
CARE:	LT85_1806
MXA:	MXAN_3644
MFU:	LILAB_26310
MSD:	MYSTI_04308
CCX:	COCOR_04376(mxcF)
SUR:	STAUR_3595(mxcF)
AGE:	AA314_04412
SCL:	sce3881(mxcF)
SCU:	SCE1572_23330
SAMY:	DB32_005870
HOH:	Hoch_2020
ATF:	Ach5_41020(entB)
ATA:	AWN88_09695
AGR:	AGROH133_13522
ARO:	B0909_15795
RIR:	BN877_II0349(entB)
BME:	BMEII0079
BMEL:	DK63_3166(entB)
BMI:	BMEA_B0016
BMZ:	BM28_B0015
BMG:	BM590_B0015
BMW:	BMNI_II0014
BMEE:	DK62_2233(entB)
BMF:	BAB2_0013
BMB:	BruAb2_0014(entB)
BMC:	BAbS19_II00120
BAA:	BAA13334_II00238
BABO:	DK55_3123(entB)
BABR:	DO74_2428(entB)
BABT:	DK49_2126(entB)
BABB:	DK48_2674(entB)
BABU:	DK53_3116(entB)
BABS:	DK51_2601(entB)
BABC:	DO78_3041(entB)
BMS:	BRA0014(entB)
BSI:	BS1330_II0014(entB)
BSF:	BSS2_II0014(entB)
BSUI:	BSSP1_II1415 BSSP1_II1416
BSUP:	BSPT1_II1406 BSPT1_II1407
BSUV:	BSPT2_II1410 BSPT2_II1411
BSUC:	BSSP2_II1419 BSSP2_II1420
BSZ:	DK67_2049(entB)
BSV:	BSVBI22_B0014(entB)
BSW:	IY71_11190
BSG:	IY72_17095
BOV:	BOV_A0011(entB)
BCS:	BCAN_B0016(phzD)
BSK:	BCA52141_II1217
BOL:	BCOUA_II0014(entB)
BCAR:	DK60_2903(entB)
BCAS:	DA85_10590
BMR:	BMI_II14(entB)
BPP:	BPI_II14(entB)
BPV:	DK65_2442(entB)
BCET:	V910_200078
BCEE:	V568_200089
BVL:	BF3285c2_0786(entB)
SNO:	Snov_3332
RVA:	Rvan_0363
BVR:	BVIR_3119 BVIR_3124
MSC:	BN69_2720
BNE:	DA69_02410
PDE:	Pden_2383
PYE:	A6J80_08715
RSU:	NHU_04521
RHM:	B5V46_19015
LAGG:	B0E33_28965
YAN:	AYJ57_22335
PABY:	Ga0080574_TMP1485
RGI:	RGI145_01180
ABS:	AZOBR_p350075(entB)
ABQ:	ABAZ39_25735
ABF:	AMK58_23120
BSU:	BSU31970(dhbB)
BSR:	I33_3288
BSL:	A7A1_2309
BSH:	BSU6051_31970(dhbB)
BSY:	I653_15400
BSUT:	BSUB_03415(dhbB)
BSUL:	BSUA_03415(dhbB)
BSUS:	Q433_17485(dhbB)
BSS:	BSUW23_15545(dhbB)
BST:	GYO_3488
BSO:	BSNT_09660(dhbB)
BSN:	BSn5_06875
BSQ:	B657_31970(dhbB)
BSX:	C663_3056(dhbB)
BSP:	U712_15930
BLI:	BL04023(dhbB)
BLD:	BLi03899(dhbB)
BLH:	BaLi_c39160(dhbB)
BAY:	RBAM_029020(dhbB)
BAQ:	BACAU_2930(dhbB)
BYA:	BANAU_3091(dhbB)
BAMP:	B938_14850(dhbB)
BAML:	BAM5036_2818(dhbB)
BAMA:	RBAU_3033(dhbB)
BAMN:	BASU_2824(dhbB)
BAMB:	BAPNAU_3081(dhbB)
BAMT:	AJ82_16425
BAMY:	V529_31620(dhbB)
BMP:	NG74_03052(dhbB)
BAO:	BAMF_2993(dhbB)
BAZ:	BAMTA208_15885(dhbB)
BQL:	LL3_03266(dhbB)
BXH:	BAXH7_03249(dhbB)
BQY:	MUS_3489(dhbB)
BAMI:	KSO_004635
BAMC:	U471_30080
BAMF:	U722_15640
BAE:	BATR1942_13805
BATR:	TD68_12905
BVM:	B9C48_14830
BAN:	BA_2371(dhbB)
BAR:	GBAA_2371(dhbB)
BAT:	BAS2207
BAH:	BAMEG_2229(bacB)
BAI:	BAA_2429(bacB)
BAX:	H9401_2250
BANT:	A16_24040
BANR:	A16R_24310
BANS:	BAPAT_2264
BANH:	HYU01_11800
BANV:	DJ46_1160(dhbB)
BCE:	BC2305
BCA:	BCE_2401(dhbB)
BCZ:	BCE33L2130(entB)
BCR:	BCAH187_A2471(bacB)
BCB:	BCB4264_A2336(bacB)
BCU:	BCAH820_2389(bacB)
BCG:	BCG9842_B2989(bacB)
BCQ:	BCQ_2297(entB)
BCX:	BCA_2438(bacB)
BAL:	BACI_c23160(entB)
BNC:	BCN_2292
BCF:	bcf_11795
BCER:	BCK_23060
BCEF:	BcrFT9_01877
BCY:	Bcer98_1757
BTK:	BT9727_2146(entB)
BTL:	BALH_2110
BTB:	BMB171_C2076(bacB)
BTT:	HD73_2592
BTHR:	YBT1520_12700
BTHI:	BTK_12865
BTC:	CT43_CH2268(bacB)
BTF:	YBT020_12040
BTM:	MC28_1577
BTG:	BTB_c23870(dhbB)
BTI:	BTG_08305
BTN:	BTF1_09040
BTHT:	H175_ch2304
BTHU:	YBT1518_12775
BTW:	BF38_3556(dhbB)
BTHY:	AQ980_18090
BWE:	BcerKBAB4_2178
BWW:	bwei_2664(dhbB)
BTY:	Btoyo_4933
BMYC:	DJ92_4946(dhbB)
BMYO:	BG05_3689(dhbB)
BPUS:	UP12_18990
BJS:	MY9_3209
GST:	HW35_12745
BACW:	QR42_18500
BACP:	SB24_14215
BACB:	OY17_17835
BBY:	CY96_10650
BACY:	QF06_14310
BACL:	BS34A_34940(dhbB)
BALM:	BsLM_3192
BEO:	BEH_16980
BGY:	BGLY_4306(dhbB)
BGI:	BGM20_10085
OIH:	OB0957(dhbB)
GMC:	GY4MC1_0170
GTH:	Geoth_0190
PTL:	AOT13_02030
ANM:	GFC28_2444(dhbB)
ANL:	GFC29_2991(dhbB)
GYM:	GYMC10_4574
PLV:	ERIC2_c15750(dhbB)
PIH:	UB51_13755
PBV:	AR543_20120
TAB:	CIG75_13305
SIV:	SSIL_0948
SSIL:	SOLI23_13875
PFT:	JBW_01673
ASD:	AS9A_0134
CTER:	A606_08105
CGY:	CGLY_03455(entB)
CPHO:	CPHO_11150
NCY:	NOCYR_4111(entB)
NBR:	O3I_007970 O3I_033020
NSL:	BOX37_24320
RHA:	RHA1_ro02318
RER:	RER_26990
REY:	O5Y_12385
REB:	XU06_12600
ROP:	ROP_20360
ROA:	Pd630_LPD06512
REQ:	REQ_08100
RPY:	Y013_21875
RAV:	AAT18_04745
GBR:	Gbro_0639 Gbro_2425
GPO:	GPOL_c23560
TPR:	Tpau_3684
DTM:	BJL86_1942
SGR:	SGR_6731
SGB:	WQO_01360
SSX:	SACTE_0625 SACTE_6072
SVE:	SVEN_0490
SALS:	SLNWT_0966
SFI:	SFUL_395
SPRI:	SPRI_0283 SPRI_7070
SCZ:	ABE83_33685
STRT:	A8713_24155 A8713_28980
KAB:	B7C62_00865
MIO:	AOA12_09215
AAI:	AARI_32920(dhbB)
RMU:	RMDY18_02520
RDN:	HMPREF0733_10559(entB)
MPH:	MLP_27460(dhbB)
TFU:	Tfu_1870
NDA:	Ndas_1027
SVI:	Svir_20850
AOI:	AORI_3540(entB)
AJA:	AJAP_21435
ALU:	BB31_04300
PSEE:	FRP1_00465
PSEQ:	AD006_08105
PECQ:	AD017_15940
PHH:	AFB00_13775
SESP:	BN6_27020 BN6_27030
KAL:	KALB_4804
KPHY:	AOZ06_18275
PMAD:	BAY61_22285
SNA:	Snas_4517
CSG:	Cylst_6411
HAU:	Haur_1804
DMR:	Deima_0183
GAU:	GAU_3220