| Entry |
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| Name |
isochorismatase;
2,3-dihydro-2,3-dihydroxybenzoate synthase;
2,3-dihydroxy-2,3-dihydrobenzoate synthase;
2,3-dihydroxy-2,3-dihydrobenzoic synthase
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| Class |
Hydrolases;
Acting on ether bonds;
Ether hydrolases
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| Sysname |
isochorismate pyruvate-hydrolase
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| Reaction(IUBMB) |
isochorismate + H2O = (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate [RN: R03037]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate;
pyruvate [CPD: C00022]
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| Comment |
The enzyme is involved in the biosynthesis of several siderophores, such as 2,3-dihydroxybenzoylglycine, enterobactin, bacillibactin, and vibriobactin.
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| History |
EC 3.3.2.1 created 1972
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| Pathway |
| Biosynthesis of siderophore group nonribosomal peptides | | Biosynthesis of secondary metabolites |
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| Orthology |
| bifunctional isochorismate lyase / aryl carrier protein |
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| Genes |
ECO: | | ECJ: | | ECD: | | EBW: | | ECOK: | | ECE: | | ECS: | | ECF: | | ETW: | | ELX: | | EOJ: | | EOI: | | EOH: | | ECG: | | EOK: | | ELR: | | ECC: | | ECP: | | ECI: | | ECV: | | ECX: | | ECW: | | ECM: | | ECY: | | ECR: | | ECQ: | | ECK: | | ECT: | | EOC: | | EUM: | | ECZ: | | ELO: | | ELN: | | ELH: | | ESE: | | ESO: | | ESM: | | ESL: | | ECL: | | EBR: | | EBD: | | EKO: | | EKF: | | EAB: | | EDH: | | EDJ: | | EIH: | | ENA: | | ELU: | | EUN: | | ELW: | | ELL: | | ELC: | | ELD: | | ELP: | | EBL: | | EBE: | | ELF: | | ECOA: | | ECOL: | | ECOI: | | ECOJ: | | ECOO: | | ECOH: | | EFE: | | STY: | | STT: | | SEX: | | SENT: | | STM: | | SEO: | | SEV: | | SEY: | | SEM: | | SEJ: | | SEB: | | SEF: | | SETU: | | SETC: | | SEEN: | | SENR: | | SEND: | | SENI: | | SPT: | | SEK: | | SPQ: | | SEI: | | SEC: | | SEH: | | SHB: | | SENH: | | SEEH: | | SEE: | | SENN: | | SEW: | | SEA: | | SENS: | | SED: | | SEG: | | SEL: | | SEGA: | | SET: | | SENJ: | | SEEC: | | SEEB: | | SEEP: | | SENB: | | SENE: | | SES: | | SBG: | | SBZ: | | SBV: | | YEL: | | SFL: | | SFX: | | SFV: | | SFE: | | SFN: | | SFS: | | SSN: | | SSJ: | | SBO: | | SBC: | | SDY: | | SDZ: | | ECA: | | PATR: | | PATO: | | PCT: | | PCC: | | PCV: | | PWA: | | PEC: | | PLU: | | PAY: | | ENT: | | ENC: | | ENO: | | ECLO: | | EEC: | | ENL: | | ECLA: | | ECLC: | | ECLG: | | ECLE: | | ECLN: | | ESC: | | EAS: | | EAU: | | EAE: | | EAR: | | ENR: | | ESA: | | CSK: | | CSZ: | | CSI: | | CTU: | | KPN: | | KPU: | | KPM: | | KPP: | | KPK: | | KPH: | | KPZ: | | KPW: | | KPY: | | KPG: | | KPQ: | | KPT: | | KPE: | | KPO: | | KPJ: | | KPI: | | KPA: | | KPS: | | KPX: | | KPB: | | KVA: | | KOX: | | KOE: | | KOY: | | KOK: | | KOM: | | CKO: | | CRO: | | CFD: | | SPE: | | SRR: | | SRL: | | SRY: | | SRS: | | SRA: | | SMAF: | | SMW: | | SLQ: | | SERR: | | SFO: | | SERF: | | SERS: | | DDA: | | DDC: | | DDD: | | DZE: | | XBO: | | PVA: | | PAO: | | KLN: | | EBT: | | ROR: | | CED: | | PGE: | | EBF: | | PSTS: | | SML: | | SMT: | | BUJ: | | SMZ: | | VCH: | | VCE: | | VCJ: | | VCO: | | VCR: | | VCM: | | VCI: | | VCL: | | VCQ: | | VVU: | | VVY: | | VVM: | | VVL: | | VHA: | | VCA: | | VAG: | | VEJ: | | VFU: | | VNI: | | VAN: | | LAG: | | PPR: | | PAEU: | | PMOS: | | PSJ: | | AVN: | | AVL: | | AVD: | | ACI: | | ACD: | | ACB: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ABJ: | | ABAB: | | ABAJ: | | ABAZ: | | ABK: | | ABAU: | | ABAA: | | ABW: | | ACC: | | SDE: | | TTU: | | HCH: | | HEL: | | MMW: | | MME: | | MPC: | | AHA: | | AHY: | | AHD: | | AHR: | | AHP: | | ASA: | | AVR: | | AMED: | | SALV: | | CVI: | | BAM: | | CDN: | | JAG: | | MXA: | | MFU: | | MSD: | | CCX: | | SUR: | | SCL: | | SCU: | | HOH: | | AGR: | | RIR: | | BME: | | BMI: | | BMZ: | | BMG: | | BMW: | | BMEE: | | BMF: | | BMB: | | BMC: | | BAA: | | BABO: | | BABR: | | BABT: | | BABB: | | BABU: | | BMS: | | BSI: | | BSF: | | BSUI: | | BSZ: | | BSV: | | BSW: | | BSG: | | BOV: | | BCS: | | BSK: | | BOL: | | BCAR: | | BCAS: | | BMR: | | BPP: | | BPV: | | BCET: | | BCEE: | | SNO: | | RVA: | | MSC: | | ABS: | | ABQ: | | BSU: | | BSR: | | BSL: | | BSH: | | BSY: | | BSUT: | | BSUL: | | BSUS: | | BSS: | | BST: | | BSO: | | BSN: | | BSQ: | | BSX: | | BSP: | | BLI: | | BLD: | | BLH: | | BAO: | | BAY: | | BAQ: | | BYA: | | BAMP: | | BAML: | | BAMA: | | BAMN: | | BAMB: | | BAMT: | | BAZ: | | BQL: | | BXH: | | BQY: | | BAMI: | | BAMC: | | BAMF: | | BAMY: | | BAE: | | BAN: | | BAR: | | BAT: | | BAH: | | BAI: | | BAX: | | BANT: | | BANR: | | BANS: | | BANH: | | BANV: | | BAL: | | BCE: | | BCA: | | BCZ: | | BCR: | | BCB: | | BCU: | | BCG: | | BCQ: | | BCX: | | BNC: | | BCF: | | BCER: | | BCEF: | | BCY: | | BTK: | | BTL: | | BTB: | | BTT: | | BTHR: | | BTHI: | | BTC: | | BTF: | | BTM: | | BTG: | | BTI: | | BTN: | | BTHT: | | BTHU: | | BWE: | | BWW: | | BTY: | | BMYC: | | BJS: | | BMP: | | GST: | | OIH: | | GTH: | | GMC: | | GYM: | | PLV: | | SIV: | | MABB: | | MMV: | | MAY: | | MABO: | | MAZ: | | MAK: | | ASD: | | CTER: | | CGY: | | NCY: | | NBR: | | RHA: | | RER: | | REY: | | ROP: | | ROA: | | REQ: | | RPY: | | GBR: | | GPO: | | TPR: | | SGR: | | SSX: | | SVE: | | SALB: | | SFI: | | AAI: | | RMU: | | RDN: | | MPH: | | TFU: | | NDA: | | NAL: | | SVI: | | AOI: | | AJA: | | SESP: | | KAL: | | SNA: | | GAU: | | CSG: | | HAU: | | DMR: | |
» show all
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| Reference |
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| Authors |
Young IG, Gibson F. |
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| Title |
Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli. |
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| Journal |
Biochim. Biophys. Acta. 177 (1969) 401-11. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 37288-64-5 |
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| LinkDB |
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