| Entry |
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| Name |
gamma-glutamyl hydrolase;
conjugase;
folate conjugase;
lysosomal gamma-glutamyl carboxypeptidase;
gamma-Glu-X carboxypeptidase;
pteroyl-poly-gamma-glutamate hydrolase;
carboxypeptidase G;
folic acid conjugase;
poly(gamma-glutamic acid) endohydrolase;
polyglutamate hydrolase;
poly(glutamic acid) hydrolase II;
pteroylpoly-gamma-glutamyl hydrolase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases
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| Reaction(IUBMB) |
Hydrolysis of a gamma-glutamyl bond
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| Reaction(KEGG) |
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| Comment |
A lysosomal or secreted, thiol-dependent peptidase, most active at acidic pH. Commonly studied with folylpoly-gamma-glutamate as substrate, with which the initial cleavage may release glutamate or poly-gamma-glutamate of two or more residues, according to the species of origin of the enzyme. Final products are pteroyl-alpha-glutamate (folic acid) and free glutamate. Highly specific for the gamma-glutamyl bond, but not for the C-terminal amino acid (leaving group). Action on gamma-glutamyl bonds is independent of an N-terminal pteroyl moiety, but it is not known whether an N-terminal gamma-Glu residue can be hydrolysed. Type example of peptidase family C26.
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| History |
EC 3.4.19.9 created 1972 as EC 3.4.12.10, transferred 1978 to EC 3.4.22.12, transferred 1992 to EC 3.4.19.9, modified 1997
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| Pathway |
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| Orthology |
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| Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | CCAN: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | BIU: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | BACU: | | LVE: | | ECB: | | MYB: | | MYD: | | HAI: | | RSS: | | PALE: | | LAV: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | CJO: | | APLA: | | TGU: | | GFR: | | FAB: | | PHI: | | CCW: | | FPG: | | FCH: | | CLV: | | AAM: | | ASN: | | AMJ: | | PSS: | | CPIC: | | ACS: | | PBI: | | GJA: | | XLA: | | XTR: | | DRE: | | IPU: | | TRU: | | TNG: | | LCO: | | MZE: | | OLA: | | XMA: | | CSEM: | | SASA: | | LCM: | | CMK: | | BFO: | | SPU: | | SKO: | | DME: | | DPO: | | DAN: | | DER: | | DPE: | | DSE: | | DSI: | | DWI: | | DYA: | | DGR: | | DMO: | | DVI: | | MDE: | | AGA: | | AAG: | | CQU: | | BIM: | | BTER: | | SOC: | | AEC: | | PBAR: | | NVI: | | TCA: | | BMOR: | | PXY: | | API: | | PHU: | | DPX: | | ISC: | | LGI: | | CRG: | | NVE: | | ADF: | | HMG: | | TAD: | | AQU: | | ATH: | | ALY: | | CRB: | | EUS: | | BRP: | | BNA: | | THJ: | | CIT: | | CIC: | | TCC: | | GRA: | | GHI: | | EGR: | | GMX: | | PVU: | | VRA: | | VAR: | | CCAJ: | | MTR: | | CAM: | | ADU: | | AIP: | | LJA: | | LANG: | | FVE: | | PPER: | | PMUM: | | MDM: | | PXB: | | ZJU: | | CSV: | | CMO: | | RCU: | | JCU: | | POP: | | VVI: | | SLY: | | SPEN: | | SOT: | | INI: | | SIND: | | BVG: | | NNU: | | OSA: | | DOSA: | | OBR: | | BDI: | | ATS: | | ZMA: | | SITA: | | PDA: | | EGU: | | MUS: | | ATR: | | SMO: | | PPP: | | CRE: | | VCN: | | MIS: | | CSL: | | CVR: | | APRO: | | MBR: | | SRE: | | DDI: | | DPP: | | DFA: | | ACAN: | | TET: | | PTM: | | SMIN: | | PTI: | | PIF: | | PSOJ: | | SPAR: | | EHX: | | GTT: | | NGR: | |
» show all
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| Reference |
1 |
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| Authors |
McGuire, J.J. and Coward, J.K. |
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| Title |
Pteroylpolyglutamates: biosynthesis, degradation and function. |
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| Journal |
In: Blakley, R.L. and Benkovic, S.J. (Eds.), Folates and Pterins, John Wiley and Sons, New York, 1984, p. 135-191. |
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| Reference |
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| Authors |
Wang Y, Nimec Z, Ryan TJ, Dias JA, Galivan J. |
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| Title |
The properties of the secreted gamma-glutamyl hydrolases from H35 hepatoma cells. |
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| Journal |
Biochim. Biophys. Acta. 1164 (1993) 227-35. |
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| Sequence |
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| Reference |
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| Authors |
Yao R, Rhee MS, Galivan J. |
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| Title |
Effects of gamma-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells. |
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| Journal |
Mol. Pharmacol. 48 (1995) 505-11. |
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| Reference |
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| Authors |
Yao R, Schneider E, Ryan TJ, Galivan J. |
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| Title |
Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro. |
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| Journal |
Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 10134-8. |
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| Sequence |
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| Reference |
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| Authors |
Yao R, Nimec Z, Ryan TJ, Galivan J. |
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| Title |
Identification, cloning, and sequencing of a cDNA coding for rat gamma-glutamyl hydrolase. |
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| Journal |
J. Biol. Chem. 271 (1996) 8525-8. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9074-87-7 |
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| LinkDB |
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