KEGG   ENZYME: 3.5.1.102Help
Entry
EC 3.5.1.102                Enzyme                                 

Name
2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase;
ArfB
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one amidohydrolase
Reaction(IUBMB)
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + formate [RN:R09374]
Reaction(KEGG)
Substrate
2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C15563];
H2O [CPD:C00001]
Product
2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C01304];
formate [CPD:C00058]
Comment
The enzyme catalyses the second step in archaeal riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin biosynthesis. The first step is catalysed by EC 3.5.4.29 (GTP cyclohydrolase IIa). The bacterial enzyme, EC 3.5.4.25 (GTP cyclohydrolase II) catalyses both reactions.
History
EC 3.5.1.102 created 2010, modified 2011
Pathway
Riboflavin metabolism
Metabolic pathways
Orthology
K14653  
2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase
Genes
MJA: 
MFE: 
MVU: 
MFS: 
MIF: 
MIG: 
MMP: 
MMQ: 
MMX: 
MMZ: 
MMD: 
GYY_09400
MAE: 
Maeo_0663
MVN: 
Mevan_1007
MVO: 
Mvol_1322
MOK: 
Metok_1397
MTH: 
MTH_651
MMG: 
MTBMA_c10310
MST: 
Msp_1177
MSI: 
Msm_0184
MRU: 
mru_1283(arfB)
MEB: 
Abm4_0796(arfB)
MEL: 
Metbo_2103
MEW: 
MSWAN_0504
METH: 
MBMB1_0319(arfB)
MFV: 
Mfer_1218
 » show all
Taxonomy
Reference
1  [PMID:19309161]
  Authors
Grochowski LL, Xu H, White RH
  Title
An iron(II) dependent formamide hydrolase catalyzes the second step in the archaeal biosynthetic pathway to riboflavin and 7,8-didemethyl-8-hydroxy-5-deazariboflavin.
  Journal
Biochemistry. 48 (2009) 4181-8.
  Sequence
[mja:MJ_0116]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
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