KEGG   ENZYME: 3.5.1.91Help
Entry
EC 3.5.1.91                 Enzyme                                 

Name
N-substituted formamide deformylase;
NfdA
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
N-benzylformamide amidohydrolase
Reaction(IUBMB)
N-benzylformamide + H2O = formate + benzylamine [RN:R07303]
Reaction(KEGG)
Substrate
N-benzylformamide [CPD:C15561];
H2O [CPD:C00001]
Product
formate [CPD:C00058];
benzylamine [CPD:C15562]
Comment
Zinc is a cofactor. While N-benzylformamide is the best substrate, the enzyme from Arthrobacter pascens can also act on the N-substituted formamides N-butylformamide, N-allylformamide, N-[2-(cyclohex-1-enyl)ethyl]formamide and N-(1-phenylethyl)formamide, but much more slowly. Amides of other acids do not act as substrates.
History
EC 3.5.1.91 created 2005
Reference
1  [PMID:15358859]
  Authors
Fukatsu H, Hashimoto Y, Goda M, Higashibata H, Kobayashi M.
  Title
Amine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloning.
  Journal
Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 13726-31.
  Sequence
[up:Q68AP4]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
115299-95-1
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