KEGG   ENZYME: 3.5.2.16Help
Entry
EC 3.5.2.16                 Enzyme                                 

Name
maleimide hydrolase;
imidase;
cyclic imide hydrolase;
cyclic-imide amidohydrolase (decyclicizing) [misprint]
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
BRITE hierarchy
Sysname
cyclic-imide amidohydrolase (decyclizing)
Reaction(IUBMB)
maleimide + H2O = maleamic acid [RN:R05781]
Reaction(KEGG)
Substrate
maleimide [CPD:C07272];
H2O [CPD:C00001]
Product
maleamic acid [CPD:C01596]
Comment
Succinimide and glutarimide, and sulfur-containing cyclic imides, such as rhodanine, can also act as substrates for the enzyme from Blastobacter sp. A17p-4. The reverse, cyclization, reaction is also catalysed, but much more slowly. It has lower activity towards cyclic ureides, which are the substrates of EC 3.5.2.2, dihydropyrimidinase.
History
EC 3.5.2.16 created 2001
Reference
1  [PMID:9030755]
  Authors
Ogawa J, Soong CL, Honda M, Shimizu S.
  Title
Imidase, a dihydropyrimidinase-like enzyme involved in the metabolism of cyclic imides.
  Journal
Eur. J. Biochem. 243 (1997) 322-7.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9030-74-4
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