EC 18.104.22.168 Enzyme
cyclic imide hydrolase;
cyclic-imide amidohydrolase (decyclicizing) [misprint];
cyclic-imide amidohydrolase (decyclizing)
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
cyclic-imide amidohydrolase (ring-opening)
maleimide + H2O = maleamic acid [RN:
maleamic acid [CPD:
Succinimide and glutarimide, and sulfur-containing cyclic imides, such as rhodanine, can also act as substrates for the enzyme from Blastobacter sp. A17p-4. The reverse, cyclization, reaction is also catalysed, but much more slowly. It has lower activity towards cyclic ureides, which are the substrates of EC
EC 22.214.171.124 created 2001
Ogawa J, Soong CL, Honda M, Shimizu S.
Imidase, a dihydropyrimidinase-like enzyme involved in the metabolism of cyclic imides.
Eur. J. Biochem. 243 (1997) 322-7.
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