| Entry |
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| Name |
GTP cyclohydrolase IV;
MptA;
GTP cyclohydrolase MptA
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
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| Sysname |
GTP 7,8-8,9-dihydrolase (cyclizing, formate-releasing, diphosphate-releasing)
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| Reaction(IUBMB) |
GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate + formate + diphosphate [RN: R10348]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
7,8-dihydroneopterin 2',3'-cyclic phosphate [CPD: C20567];
formate [CPD: C00058];
diphosphate [CPD: C00013]
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| Comment |
Requires Fe2+. A zinc protein. The enzyme is involved in methanopterin biosynthesis in methanogenic archaea. cf. GTP cyclohydrolase I (EC 3.5.4.16), GTP cyclohydrolase II (EC 3.5.4.25) and GTP cyclohydrolase IIa (EC 3.5.4.29).
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| History |
EC 3.5.4.39 created 2013
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| Orthology |
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| Genes |
TFL: | | AMO: | | MJA: | | MFE: | | MVU: | | MFS: | | MIF: | | MJH: | | MIG: | | MMP: | | MMQ: | | MMX: | | MMZ: | | MMD: | | MMAK: | | MMAO: | | MAE: | | MVN: | | MVO: | | MOK: | | MAC: | | MBA: | | MBY: | | MBW: | | MBAR: | | MBAK: | | MMA: | | MMAZ: | | MMJ: | | MMAC: | | MVC: | | MEK: | | MLS: | | METM: | | MEF: | | MEQ: | | MSJ: | | MSZ: | | MSW: | | MTHE: | | MTHR: | | MHOR: | | MBU: | | MMET: | | MMH: | | MHAZ: | | MEV: | | MZH: | | MPY: | | MHZ: | | MTP: | | MCJ: | | MHI: | | MHU: | | MLA: | | MEM: | | MBG: | | MEMA: | | MPI: | | MBN: | | MFO: | | MPL: | | MPD: | | MEZ: | | RCI: | | MTH: | | MMG: | | METC: | | MWO: | | MST: | | MSI: | | MRU: | | MEB: | | MMIL: | | MEYE: | | MOL: | | MEL: | | MEW: | | METH: | | MFC: | | MFI: | | MCUB: | | MFV: | | MKA: | | AFU: | | AFG: | | APO: | | AVE: | | AST: | | FPL: | | GAC: | | GAH: | | HAL: | | HSL: | | HDL: | | HHB: | | HJE: | | HALH: | | HHSR: | | HMA: | | HHI: | | HHN: | | HAB: | | NPH: | | NMO: | | HUT: | | HTI: | | HMU: | | HALI: | | HSU: | | HSF: | | HWA: | | HWC: | | HVO: | | HME: | | HGI: | | HBO: | | HLA: | | HTU: | | HDA: | | NMG: | | HXA: | | NAT: | | NPE: | | NGE: | | HRU: | | NOU: | | SALI: | | HLR: | | HLC: | | TAC: | | TVO: | | PTO: | | CDIV: | | TAR: | | MAX: | | MER: | | MEAR: | | MARC: | | PHO: | | PAB: | | PFU: | | PFI: | | PYN: | | PYA: | | PYS: | | PYC: | | TKO: | | TON: | | TGA: | | TSI: | | TBA: | | THE: | | THA: | | THM: | | TLT: | | THS: | | TNU: | | TEU: | | TGY: | | THV: | | TCH: | | TPEP: | | PPAC: | | ABI: | | ACF: | | APE: | | ACJ: | | SHC: | | DKA: | | DFD: | | DMU: | | TAG: | | IAG: | | THG: | | ASC: | | CLG: | | FFO: | | CSU: | | KCR: | | LOKI: | | HAH: | |
» show all
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| Reference |
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| Authors |
Grochowski LL, Xu H, Leung K, White RH |
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| Title |
Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii. |
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| Journal |
Biochemistry. 46 (2007) 6658-67. |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: |
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| LinkDB |
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