| Entry |
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| Name |
2,3-epoxybenzoyl-CoA dihydrolase;
2,3-dihydro-2,3-dihydroxybenzoyl-CoA lyase/hydrolase (deformylating);
BoxC;
dihydrodiol transforming enzyme;
benzoyl-CoA oxidation component C;
2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA semialdehyde-lyase (formate-forming);
benzoyl-CoA-dihydrodiol lyase (incorrect);
2,3-dihydro-2,3-dihydroxybenzoyl-CoA 3,4-didehydroadipyl-CoA-semialdehyde-lyase (formate-forming)
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| Class |
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
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| Sysname |
2,3-epoxy-2,3-dihydrobenzoyl-CoA (3Z)-6-oxohex-3-enoyl-CoA-lyase (formate-forming)
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| Reaction(IUBMB) |
2,3-epoxy-2,3-dihydrobenzoyl-CoA + 2 H2O = (3Z)-6-oxohex-3-enoyl-CoA + formate [RN: R09556]
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| Reaction(KEGG) |
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| Substrate |
2,3-epoxy-2,3-dihydrobenzoyl-CoA [CPD: C19684];
H2O [CPD: C00001]
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| Product |
(3Z)-6-oxohex-3-enoyl-CoA [CPD: C19683];
formate [CPD: C00058]
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| Comment |
The enzyme is involved in the aerobic benzoyl-CoA catabolic pathway of the bacterium Azoarcus evansii. The enzyme converts 2,3-epoxy-2,3-dihydrobenzoyl-CoA to its oxepin form prior to the ring-opening and the formation of a dialdehyde intermediate.
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| History |
EC 4.1.2.44 created 2010, modified 2015
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| Orthology |
| benzoyl-CoA-dihydrodiol lyase |
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| Genes |
ADI: | | AXE: | | RPJ: | | REU: | | REH: | | CNC: | | RME: | | CTI: | | CBW: | | CGD: | | CCUP: | | BUG: | | BGE: | | BGF: | | BUQ: | | BXE: | | BXB: | | BPH: | | BRH: | | BPX: | | BPY: | | BFN: | | BCAI: | | PSPW: | | PPK: | | PPNO: | | PPNM: | | PRB: | | PPUL: | | PSPU: | | PAPI: | | PVE: | | POX: | | PTX: | | PFG: | | PNR: | | BPT: | | BHO: | | BHM: | | BHZ: | | BBRO: | | BFZ: | | AXY: | | AXO: | | AXN: | | AXS: | | ADT: | | AIS: | | AKA: | | AMIM: | | CDN: | | RFR: | | POL: | | PNA: | | ACK: | | VEI: | | DAC: | | DEL: | | DTS: | | DHK: | | VAP: | | VPE: | | VPD: | | CTT: | | CTES: | | RTA: | | LIM: | | LIH: | | HYR: | | HYB: | | HYL: | | CBAA: | | LCH: | | THI: | | SHD: | | EBA: | | AZO: | | AZA: | | AZI: | | TMZ: | | TCL: | | VIN: | | SCL: | | SCU: | | CCRO: | | SAMY: | | LLU: | | MRM: | | HOH: | | MESO: | | BJA: | | BJU: | | BJP: | | BRA: | | BBT: | | BRS: | | AOL: | | BRC: | | BIC: | | RPA: | | RPB: | | RPD: | | RPE: | | RPT: | | RPX: | | RHZ: | | PSIN: | | RBM: | | SIL: | | JAN: | | PTP: | | SUAM: | | TOM: | | MAG: | | MAGX: | | MAGN: | | GOQ: | | NOA: | | BSD: | | AMD: | | AMN: | | AMM: | | AMZ: | | AOI: | | AJA: | | AMQ: | | ALU: | | PDX: | | PSEE: | | PSEH: | | PSEQ: | | PECQ: | | PHH: | | KPHY: | | CAI: | |
» show all
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| Reference |
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| Authors |
Gescher J, Eisenreich W, Worth J, Bacher A, Fuchs G |
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| Title |
Aerobic benzoyl-CoA catabolic pathway in Azoarcus evansii: studies on the non-oxygenolytic ring cleavage enzyme. |
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| Journal |
Mol. Microbiol. 56 (2005) 1586-600. |
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| Sequence |
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| Reference |
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| Authors |
Rather LJ, Knapp B, Haehnel W, Fuchs G |
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| Title |
Coenzyme A-dependent aerobic metabolism of benzoate via epoxide formation. |
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| Journal |
J. Biol. Chem. 285 (2010) 20615-24. |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: UM-BBD (Biocatalysis/Biodegradation Database): BRENDA, the Enzyme Database: |
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| LinkDB |
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