KEGG   ENZYME: 4.4.1.24Help
Entry
EC 4.4.1.24                 Enzyme                                 

Name
(2R)-sulfolactate sulfo-lyase;
Suy;
SuyAB;
3-sulfolactate bisulfite-lyase;
sulfolactate sulfo-lyase (ambigious);
(2R)-3-sulfolactate bisulfite-lyase (pyruvate-forming)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2R)-3-sulfolactate hydrogensulfite-lyase (pyruvate-forming)
Reaction(IUBMB)
(2R)-3-sulfolactate = pyruvate + hydrogensulfite [RN:R07633]
Reaction(KEGG)
Substrate
(2R)-3-sulfolactate [CPD:C11537]
Product
pyruvate [CPD:C00022];
hydrogensulfite
Comment
Requires iron(II). This inducible enzyme participates in cysteate degradation by the bacterium Paracoccus pantotrophus NKNCYSA and in 3-sulfolactate degradation by the bacterium Chromohalobacter salexigens. The enzyme is specific for the (R) isomer of its substrate.
History
EC 4.4.1.24 created 2006, modified 2011
Pathway
ec00270  Cysteine and methionine metabolism
Orthology
K16845  (2R)-sulfolactate sulfo-lyase subunit alpha
K16846  (2R)-sulfolactate sulfo-lyase subunit beta
Genes
GHO: AL542_00730 AL542_00735
APRS: BI364_08775 BI364_08780
CSA: Csal_1765 Csal_1766
HBE: BEI_0833(suyA) BEI_0834(suyB)
SVA: SVA_1848 SVA_1849
TSN: W908_01095 W908_01100
RPJ: N234_02625 N234_02630
REU: Reut_B3528 Reut_B3529 Reut_C6087 Reut_C6088
CTI: RALTA_B0839 RALTA_B0840
CBW: RR42_m0459 RR42_m0460
CGD: CR3_0181(suyA) CR3_0182(suyB)
LIH: L63ED372_00897(suyB) L63ED372_00898(suyA)
HAR: HEAR3336 HEAR3337(uxaA)
RGE: RGE_25210(suyB) RGE_25220
VGO: GJW-30_1_00129(suyB_1) GJW-30_1_00130(suyA)
SAY: TPY_1962(uxaA) TPY_1963
RHA: RHA1_ro08847(suyA) RHA1_ro08848(suyB)
SSO: SSO1259(garD) SSO1260
 » show all
Taxonomy
Reference
1  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat. Prod. Rep. 19 (2002) 133-47.
Reference
2  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM.
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology. 151 (2005) 737-47.
  Sequence
Reference
3  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology. 156 (2010) 967-74.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.24
IUBMB Enzyme Nomenclature: 4.4.1.24
ExPASy - ENZYME nomenclature database: 4.4.1.24
BRENDA, the Enzyme Database: 4.4.1.24
CAS: 1256650-35-7
LinkDB All DBs

DBGET integrated database retrieval system