KEGG   ENZYME: 4.4.1.24Help
Entry
EC 4.4.1.24                 Enzyme                                 
Name
(2R)-sulfolactate sulfo-lyase;
Suy;
SuyAB;
3-sulfolactate bisulfite-lyase;
sulfolactate sulfo-lyase (ambiguous)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(2R)-3-sulfolactate bisulfite-lyase (pyruvate-forming)
Reaction(IUBMB)
(2R)-3-sulfolactate = pyruvate + bisulfite [RN:R07633]
Reaction(KEGG)
Substrate
(2R)-3-sulfolactate [CPD:C11537]
Product
pyruvate [CPD:C00022];
bisulfite [CPD:C11481]
Comment
Requires iron(II). This inducible enzyme participates in cysteate degradation in Paracoccus pantotrophus NKNCYSA and in 3-sulfolactate degradation in Chromohalobacter salexigens. The enzyme is specific for the (R) isomer.
Pathway
Cysteine and methionine metabolism
Orthology
K16845  
(2R)-sulfolactate sulfo-lyase subunit alpha
K16846  
(2R)-sulfolactate sulfo-lyase subunit beta
Genes
CSA: 
REU: 
CTI: 
BPT: 
AXY: 
AKA: 
VEI: 
VAP: 
HAR: 
RGE: 
BPRC: 
D521_1331 D521_1332
DVM: 
DvMF_2003 DvMF_2004 DvMF_2005 DvMF_2006
DDS: 
Ddes_2374 Ddes_2375
DBA: 
Dbac_2155 Dbac_2156
DRT: 
Dret_2324 Dret_2325
DTI: 
Desti_1900 Desti_1901 Desti_3262 Desti_3263
PUB: 
SAR11_0842(garD) SAR11_0843
OCA: 
OCAR_7557 OCAR_7558
OCG: 
OCA5_c05830 OCA5_c05840(garD)
OCO: 
OCA4_c05820 OCA4_c05830(garD)
MRD: 
Mrad2831_5979 Mrad2831_5980
MNO: 
Mnod_3705 Mnod_3706
RVA: 
Rvan_3576 Rvan_3577
DSH: 
Dshi_2037 Dshi_2038
APM: 
HIMB5_00005030 HIMB5_00005040
DSY: 
DSY0965 DSY0966 DSY3251 DSY3252
DHD: 
Dhaf_2050 Dhaf_2051 Dhaf_4418 Dhaf_4419
DDH: 
Desde_3797 Desde_3798
DDL: 
Desdi_3120 Desdi_3121 Desdi_3123 Desdi_3124
DKU: 
Desku_3257 Desku_3258
DRU: 
Desru_0086 Desru_0087 Desru_0601 Desru_1694 Desru_1695 Desru_1700
SAY: 
TPY_1962(uxaA) TPY_1963
SAP: 
Sulac_2158 Sulac_2159
MAS: 
Mahau_2704 Mahau_2705
RHA: 
RHA1_ro08847 RHA1_ro08848
MPH: 
MLP_21600 MLP_21610
RXY: 
Rxyl_2590 Rxyl_2591
MRB: 
Mrub_2462 Mrub_2463
MRE: 
K649_10215 K649_10220
MSV: 
Mesil_1011 Mesil_1012
TNA: 
CTN_1545 CTN_1546
TTA: 
Theth_1763 Theth_1764
DTU: 
Dtur_0481 Dtur_0482
TAC: 
Ta1392 Ta1393
SSO: 
SSO1259(garD) SSO1260
SOL: 
Ssol_2216 Ssol_2217
STO: 
ST2559 ST2560
SIS: 
LS215_0489 LS215_0490
SIA: 
M1425_0434 M1425_0435
SIM: 
M1627_0445 M1627_0446
SID: 
M164_0471 M164_0472
SIY: 
YG5714_0443 YG5714_0444
SIN: 
YN1551_2572 YN1551_2573
SII: 
LD85_0490 LD85_0491
SIH: 
SiH_0939 SiH_0940
SIR: 
SiRe_0429 SiRe_0430
SIC: 
SiL_0462 SiL_0463
MSE: 
Msed_1123 Msed_1124
AHO: 
Ahos_0318 Ahos_0319
CMA: 
Cmaq_1140 Cmaq_1141
TUZ: 
TUZN_0136 TUZN_0137
VMO: 
VMUT_1151 VMUT_1152
 » show all
Taxonomy
Reference
1  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat. Prod. Rep. 19 (2002) 133-47.
Reference
2  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM.
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology. 151 (2005) 737-47.
  Organism
Paracoccus pantotrophus
Reference
3  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology. 156 (2010) 967-74.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
1256650-35-7
DBGET integrated database retrieval system