| Entry |
|
|---|
| Name |
isopentenyl-diphosphate Delta-isomerase;
isopentenylpyrophosphate Delta-isomerase;
methylbutenylpyrophosphate isomerase;
isopentenylpyrophosphate isomerase |
|---|
| Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
 |
|---|
| Sysname |
isopentenyl-diphosphate Delta3-Delta2-isomerase |
|---|
| Reaction(IUBMB) |
isopentenyl diphosphate = dimethylallyl diphosphate [RN:R01123] |
|---|
| Reaction(KEGG) |
R01123
 |
|---|
| Substrate |
isopentenyl diphosphate [CPD:C00129] |
|---|
| Product |
dimethylallyl diphosphate [CPD:C00235] |
|---|
| Comment |
The enzyme from Streptomyces sp. strain CL190 requires FMN and
NAD(P)H as cofactors. Activity is reduced if FMN is replaced by FAD,
but the enzyme becomes inactive when NAD(P)H is replaced by NAD+ or
NADP+. That enzyme also requires Mg2+, Mn2+ or Ca2+ for activity. |
|---|
| Pathway |
ec00900 Terpenoid backbone biosynthesis
ec01100 Metabolic pathways
ec01110 Biosynthesis of secondary metabolites |
|---|
| Orthology |
K01823 isopentenyl-diphosphate delta-isomerase |
|---|
| Genes |
HSA: 3422(IDI1) 91734(IDI2)
PTR: 450262(IDI2) 450263(IDI1)
MCC: 710052
MMU: 100044783 319554(Idi1)
RNO: 291266(RGD1564999) 89784(Idi1)
BTA: 514293(IDI1)
ECB: 100071228
MDO: 100021550 100021613 100021638
OAA: 100080658
GGA: 420459(IDI1)
TGU: 100223263
XLA: 494671(idi1)
XTR: 496783(idi1)
DRE: 553513(idi1)
BFO: BRAFLDRAFT_76431
CIN: 100186921
SPU: 586184
DME: Dmel_CG5919
DPO: Dpse_GA19228
DAN: Dana_GF17702
DER: Dere_GG24520
DPE: Dper_GL27329
DSE: Dsec_GM15083
DSI: Dsim_GD19412
DWI: Dwil_GK14497
DYA: Dyak_GE25722
DGR: Dgri_GH21955
DMO: Dmoj_GI21943
DVI: Dvir_GJ14302
AGA: AgaP_AGAP001704
AAG: AaeL_AAEL006144
CQU: CpipJ_CPIJ017833
AME: 725363
NVI: 100116989(NV15223)
TCA: 660176
API: 100166744(ACYPI007594) 100167596(ACYPI008380)
PHU: Phum_PHUM459520
CEL: K06H7.9(idi-1)
CBR: CBG22969(Cbr-idi-1)
BMY: Bm1_16940
NVE: NEMVE_v1g121175
HMG: 100207619
TAD: TRIADDRAFT_22592
ATH: AT3G02780(IPP2) AT5G16440(IPP1)
POP: POPTR_809590
RCU: RCOM_1078490
VVI: 100241072
OSA: 4338791(Os05g0413400) 4343523(Os07g0546000)
SBI: SORBI_02g035700 SORBI_09g020370
ZMA: 541901(umc1301)
PPP: PHYPADRAFT_56143
CRE: CHLREDRAFT_24471(IDI1)
OLU: OSTLU_13493
CME: CMB062C
SCE: YPL117C(IDI1)
AGO: AGOS_ADL268C
KLA: KLLA0F00924g
LTH: KLTH0D09658g
PPA: PAS_chr1-4_0429
VPO: Kpol_479p9
ZRO: ZYRO0F10846g
CGR: CAGL0J06952g
DHA: DEHA2G18832g
PIC: PICST_68990(IDI1)
PGU: PGUG_02383
LEL: LELG_04388
CTP: CTRG_00166
CDU: CD36_42170
YLI: YALI0F04015g
CLU: CLUG_04976
NCR: NCU07719
PAN: PODANSg7228
MGR: MGG_07125(MG07125.4)
FGR: FG09722.1
BFU: BC1G_11480
ANI: AN0579.2
AFM: AFUA_6G11160
NFI: NFIA_056850
AOR: AO090023000500
ANG: An08g07570
AFV: AFLA_109160
ACT: ACLA_084820
PCS: Pc21g21730
CIM: CIMG_00236
URE: UREG_00325
PNO: SNOG_08955
TML: GSTUM_00006247001
SPO: SPBC106.15(idi1)
CNE: CNA02550
CNB: CNBA2380
LBC: LACBIDRAFT_291469
MPR: MPER_02905
CCI: CC1G_11292
UMA: UM04838.1
MGL: MGL_1929
ECU: ECU02_0230
MBR: MONBRDRAFT_34433
NGR: NAEGRDRAFT_83092
DDI: DDB_G0290011(ipi)
EHI: EHI_194410(46.t00025)
EDI: EDI_289600
TET: TTHERM_00237280 TTHERM_00438860
PTM: GSPATT00007643001
TBR: Tb09.211.0700
TCR: 408799.19 510431.10
LMA: LmjF35.5330
LIF: LinJ35.5260
LBZ: LbrM34_V2.5270
GLA: GL50803_6335
TVA: TVAG_116230 TVAG_495540
PTI: PHATRDRAFT_12533 PHATRDRAFT_12972
TPS: THAPSDRAFT_31266
ECO: b2889(idi)
ECJ: JW2857(idi)
ECD: ECDH10B_3063(idi)
EBW: BWG_2614(idi)
ECE: Z4227
ECS: ECs3761
ECF: ECH74115_4179(idi)
ETW: ECSP_3858(idi)
EOJ: ECO26_3978(idi)
EOI: ECO111_3627(idi)
EOH: ECO103_3464(idi)
ECG: E2348C_3142(idi)
EOK: G2583_3542(idi)
ECC: c3467
ECP: ECP_2882
ECI: UTI89_C3274
ECV: APECO1_3638
ECX: EcHS_A3048(idi)
ECW: EcE24377A_3215(idi)
ECM: EcSMS35_3022(idi)
ECY: ECSE_3152
ECR: ECIAI1_3008(idi)
ECQ: ECED1_3348(idi)
ECK: EC55989_3175(idi)
ECT: ECIAI39_3305(idi)
EUM: ECUMN_3231(idi)
ECZ: ECS88_3169(idi)
ECL: EcolC_0820
EBR: ECB_02721(idi)
EBD: ECBD_0848
EFE: EFER_2824(idi)
STY: STY3195
STT: t2957
STM: STM3039(idi)
SPT: SPA2907(idi)
SEK: SSPA2708
SPQ: SPAB_03786
SEI: SPC_3098(idi)
SEC: SC2979(idi)
SEH: SeHA_C3270(idi)
SEE: SNSL254_A3273(idi)
SEW: SeSA_A3207(idi)
SEA: SeAg_B3195(idi)
SED: SeD_A3375(idi)
SEG: SG2934(idi)
SET: SEN2882(idi)
SES: SARI_04611
SFL: SF2875
SFX: S3074
SFV: SFV_2937
SSN: SSON_3042
SBO: SBO_3103
SBC: SbBS512_E3308(idi)
SDY: SDY_3193
ECA: ECA2789
PCT: PC1_1548
PWA: Pecwa_2914
ETA: ETA_22390(idi)
EPY: EpC_23710(idi)
EAM: EAMY_1238(mvaD)
EAY: EAM_1238(idi)
EBI: EbC_13810(idi)
PLU: plu3987
PAY: PAU_03622(idi2)
ENT: Ent638_3307
ENC: ECL_04214
ESA: ESA_00346
CTU: Ctu_35400(fni)
KPN: KPN_03317(idi)
KPE: KPK_0781(idi)
KPU: KP1_4604(idi)
KVA: Kvar_0748
CKO: CKO_04250
CRO: ROD_49441(idi)
SPE: Spro_2201
PMR: PMI2767
EIC: NT01EI_3775
ETR: ETAE_3401
PAM: PANA_1249(idi)
VPA: VPA0278
VHA: VIBHAR_04924
VEX: VEA_000726
VFI: VF_0403(idi)
VFM: VFMJ11_0393(idi)
PPR: PBPRA0469
PEN: PSEEN4850
PSA: PST_3876
AVN: Avin_20640(idi)
TTU: TERTU_3249(idi)
CBU: CBU_0607(mvaD)
CBS: COXBURSA331_A0720(mvaD)
CBD: CBUD_0619(mvaD)
CBG: CbuG_1396(mvaD)
CBC: CbuK_1443(mvaD)
LPN: lpg2051
LPF: lpl2029
LPP: lpp2034
LPC: LPC_1537(fni)
LPA: lpa_02993
LLO: LLO_0238(fni)
TCX: Tcr_1718
ALV: Alvin_2544
HHA: Hhal_1623
DNO: DNO_0798
BMU: Bmul_5942
BMJ: BMULJ_05584(idi)
EBA: ebA5678 p2A143
DVU: DVU1679(idi)
DDE: Dde_1991
LIP: LI1134
DBA: Dbac_0666
BBA: Bd1626
AFW: Anae109_4082
MXA: MXAN_5021(fni)
SCL: sce1761(idi)
HOH: Hoch_3410
DBR: Deba_2887
RPR: RP452
RTY: RT0439(idi)
RCM: A1E_02555
RCO: RC0744
RFE: RF_0785(fni)
RAK: A1C_04195
RRI: A1G_04195
RRJ: RrIowa_0882
RMS: RMA_0766(fni)
RPK: RPR_02950
RAF: RAF_ORF0665(fni)
RBE: RBE_0731(fni)
RBO: A1I_04760
MLO: mlr6371
MES: Meso_4299
RET: RHE_PD00245(ypd00046)
REC: RHECIAT_PB0000285
LAS: CLIBASIA_04610
XAU: Xaut_4134
BSB: Bresu_2275
SIL: SPO0131
SIT: TM1040_3442
RSP: RSP_0276
RSH: Rsph17029_1919
RSQ: Rsph17025_1019
RSK: RSKD131_1602
RCP: RCAP_rcc00028(idi1) RCAP_rcc00674(idi2)
JAN: Jann_0168
RDE: RD1_0147(idi)
DSH: Dshi_3527(idi)
RCE: RC1_2077(idi)
PBR: PB2503_11214
APB: SAR116_2132
BSU: BSU22870(fni)
BAN: BA_1520
BAR: GBAA_1520
BAT: BAS1409
BAH: BAMEG_3073
BAI: BAA_1589
BAL: BACI_c15430(fni)
BCE: BC1499
BCA: BCE_1626
BCZ: BCZK1380(fni)
BCR: BCAH187_A1662
BCB: BCB4264_A1554
BCU: BCAH820_1593
BCG: BCG9842_B3790
BCQ: BCQ_1569(fni)
BCX: BCA_1558
BCY: Bcer98_1222
BTK: BT9727_1381(fni)
BTL: BALH_1354
BTB: BMB171_C1332
BWE: BcerKBAB4_1422
BLI: BL02217(fni)
BLD: BLi02426
BAY: RBAM_021020(fni)
BPU: BPUM_2020(fni)
BPF: BpOF4_15340
BMQ: BMQ_4343(fni)
BMD: BMD_4329(fni)
BSE: Bsel_2145
OIH: OB0537
GWC: GWCH70_2168
GYM: GYMC10_5929
AFL: Aflv_1080
SAU: SA2136(fni)
SAV: SAV2346(fni)
SAW: SAHV_2330(fni)
SAH: SaurJH1_2416
SAJ: SaurJH9_2370
SAM: MW2267(fni)
SAS: SAS2237
SAR: SAR2431(fni)
SAC: SACOL2341(fni)
SAX: USA300HOU_2327
SAA: SAUSA300_2292(fni)
SAO: SAOUHSC_02623
SAE: NWMN_2247(idi)
SAD: SAAV_2410(fni)
SAB: SAB2225c(fni)
SEP: SE1925
SER: SERP1937(fni-2)
SHA: SH0712(fni)
SSP: SSP0556
SCA: Sca_1847(fni)
SLG: SLGD_00693
LMO: lmo1383
LMF: LMOf2365_1402(fni)
LMH: LMHCC_1186
LMC: Lm4b_01392
LMN: LM5578_1524
LMY: LM5923_1476
LIN: lin1420
LWE: lwe1399(fni)
LSG: lse_1300
BBE: BBR47_24440(fni)
PJD: Pjdr2_4464
AAC: Aaci_2447
LLA: L11083(yebB)
LLK: LLKF_0459(idi)
LLC: LACR_0457
LLM: llmg_0428(fni)
SPY: SPy_0879
SPZ: M5005_Spy_0685
SPM: spyM18_0940
SPG: SpyM3_0598
SPS: SPs1255
SPH: MGAS10270_Spy0743
SPI: MGAS10750_Spy0777
SPJ: MGAS2096_Spy0756
SPK: MGAS9429_Spy0740
SPF: SpyM51123(fni)
SPA: M6_Spy0702
SPB: M28_Spy0665
SOZ: Spy49_0693
SPN: SP_0384
SPD: SPD_0349(fni)
SPR: spr0341(fni)
SPW: SPCG_0379(fni)
SPX: SPG_0349
SNE: SPN23F_03560(fni)
SPV: SPH_0491(fni)
SNM: SP70585_0455(fni)
SJJ: SPJ_0371(fni)
SPP: SPP_0422(fni)
SNT: SPT_0429(fni)
SNC: HMPREF0837_10682(fni)
SAG: SAG1323
SAN: gbs1393
SAK: SAK_1354(fni)
SMU: SMU.939
SMC: SmuNN2025_1089
STC: str0562(idi)
STL: stu0562(idi)
STE: STER_0601
SSA: SSA_0336
SSU: SSU05_0292
SSV: SSU98_0288
SSB: SSUBM407_0263(fni)
SSI: SSU0272(fni)
SSS: SSUSC84_0261(fni)
SGO: SGO_0242
SEQ: SZO_08860
SEZ: Sez_1081
SEU: SEQ_1107
SUB: SUB0768(fni)
SDS: SDEG_0836
SGA: GALLO_1263
SMB: smi_1744
LPL: lp_1732(idi1)
LPJ: JDM1_1455(idi1)
LJO: LJ1208
LJF: FI9785_972(idi)
LAC: LBA1171
LSA: LSA0905(idi)
LSL: LSL_0682
LDB: Ldb0996(fni)
LBU: LBUL_0903
LBR: LVIS_0861
LCA: LSEI_1493
LCB: LCABL_17150(fni)
LCZ: LCAZH_1485
LGA: LGAS_1036
LRE: Lreu_0912
LRF: LAR_0859
LHE: lhv_1278
LFE: LAF_1195
LRH: LGG_01500(fni)
LRL: LC705_01515(fni)
LCR: LCRIS_01178(idi)
PPE: PEPE_0924
EFA: EF0901
OOE: OEOE_1103
LME: LEUM_1388
LCI: LCK_00620
LKI: LKI_01550
LGS: LEGAS_1196(fni)
CBE: Cbei_3081
STH: STH1674
SWO: Swol_1341
SLP: Slip_1481
AFN: Acfer_1238
DRM: Dred_0474
HMO: HM1_1981(fni)
FMA: FMG_1144
APR: Apre_0190
ERE: EUBREC_0755
MTA: Moth_1328
TOC: Toce_1157
NTH: Nther_1637
ACL: ACL_0797(idi)
MTU: Rv1745c(idi)
MTC: MT1787(idi)
MRA: MRA_1756(idi)
MTF: TBFG_11763
MTB: TBMG_02250(TBMG_02250.1)
MBO: Mb1774c(idi)
MBB: BCG_1784c(idi)
MBT: JTY_1759(idi)
MPA: MAP3079c
MAV: MAV_3894(fni)
MSM: MSMEG_1057(fni) MSMEG_2337(fni)
MUL: MUL_0380(idi2)
MVA: Mvan_1582 Mvan_2176
MGI: Mflv_1842 Mflv_4187
MAB: MAB_3242
MMC: Mmcs_1954
MKM: Mkms_2000
MJL: Mjls_1934
MMI: MMAR_3218(idi) MMAR_4812(idi2)
CGL: NCgl2223(cgl2305)
CGB: cg2531(idi)
CGT: cgR_2177
CEF: CE2207
CDI: DIP1730(idi)
CAR: cauri_1819(idi)
CKP: ckrop_0029(idi)
CPU: cpfrc_01545(idi)
NFA: nfa19790 nfa22100
RHA: RHA1_ro00239
GBR: Gbro_2543
SRT: Srot_0532
SCO: SCO6750(SC5F2A.33c)
SMA: SAV_1663(idi)
SGR: SGR_977
SCB: SCAB_13111
LXX: Lxx23810(idi)
CMI: CMM_2889(idiA)
CMS: CMS_2609(idi)
AAU: AAur_0321(idi)
KRH: KRH_03040(idi)
MLU: Mlut_21260
BCV: Bcav_0969
BFA: Bfae_04480
JDE: Jden_0343
KSE: Ksed_13780
SKE: Sked_12740
CFL: Cfla_3045
PAC: PPA2115
PAK: HMPREF0675_5171
KFL: Kfla_1887
NDA: Ndas_2618 Ndas_4870
TCU: Tcur_1754
SRO: Sros_9366
FRA: Francci3_4188
FRE: Franean1_5570
FAL: FRAAL6504(idi)
NML: Namu_2029
GOB: Gobs_1382
KRA: Krad_3991
SEN: SACE_2627(idiB_2) SACE_5210(idi)
SVI: Svir_37460
TBI: Tbis_3569
AMD: AMED_8998(idi)
AMI: Amir_5294
STP: Strop_4438
SAQ: Sare_4564 Sare_4928
MAU: Micau_0242
CAI: Caci_5925
GVA: HMPREF0424_0314(fni)
RXY: Rxyl_0400
SHI: Shel_24100
OLS: Olsu_1461
WCH: wcw_1116(fni)
BBU: BB0684
BBZ: BbuZS7_0704(fni)
BGA: BG0707
BTU: BT0684
BHR: BH0684
BDU: BDU_687
BRE: BRE_690
SRU: SRU_1900(idi)
SRM: SRM_02110(idi)
CHU: CHU_0674(idi)
DFE: Dfer_2032
CPI: Cpin_4731
PHE: Phep_2276
GFO: GFO_2363(idi)
FJO: Fjoh_0269
FPS: FP1792(idi)
FBA: FIC_00523
COC: Coch_2043
RBI: RB2501_02010
ZPR: ZPR_1174
CAT: CA2559_13638
BBL: BLBBGE_190(idi)
BPI: BPLAN_445(idi)
LBA: Lebu_1675
SMF: Smon_0009
SYN: sll1556
SYC: syc2161_c
SYF: Synpcc7942_1933
SYP: SYNPCC7002_A1132(fni)
CYA: CYA_2395(fni)
CYB: CYB_2691(fni)
TEL: tll1403
MAR: MAE_56570
CYT: cce_1202
CYP: PCC8801_4020
CYC: PCC7424_4607
CYN: Cyan7425_3586
CYH: Cyan8802_4058
ANA: all4591
NPU: Npun_R1243
AVA: Ava_2461 Ava_B0346
NAZ: Aazo_4596
TER: Tery_1589
AMR: AM1_4374(fni)
CTE: CT0257
CPC: Cpar_1777
CCH: Cag_1445
CPH: Cpha266_0385
CPB: Cphamn1_0417
CLI: Clim_0316
PVI: Cvib_1545
PLT: Plut_1764
PPH: Ppha_0414
PAA: Paes_0384
CTS: Ctha_0403
RRS: RoseRS_2437
RCA: Rcas_2215
CAU: Caur_3877
CAG: Cagg_0435
CHL: Chy400_4188
HAU: Haur_4687
DRA: DR_1087
DGE: Dgeo_1381
DDR: Deide_09340
TRA: Trad_2168
TTH: TT_P0067
TTJ: TTHB110
MRB: Mrub_0397
MSV: Mesil_1495
TTR: Tter_2044
MJA: MJ_0862
MFE: Mefer_1122
MVU: Metvu_0279
MFS: MFS40622_1300
MMP: MMP0043
MMQ: MmarC5_1637
MMX: MmarC6_0906
MMZ: MmarC7_1040
MAE: Maeo_1184
MVN: Mevan_1058
MVO: Mvol_1388
MAC: MA0604(idi)
MBA: Mbar_A1419
MMA: MM_1764
MBU: Mbur_2397
MMH: Mmah_1551
MEV: Metev_0323
MTP: Mthe_0474
MHU: Mhun_2888
MLA: Mlab_0683 Mlab_1665
MEM: Memar_1814
MBN: Mboo_2211
MPL: Mpal_2374
MPD: MCP_1637(fni)
MTH: MTH48
MMG: MTBMA_c05370(fni)
MST: Msp_0856(fni)
MSI: Msm_1441
MRU: mru_0922(fni)
MKA: MK0776(lldD)
AFU: AF2287
APO: Arcpr_1563
FPL: Ferp_1503
HAL: VNG1818G(idi) VNG6081G(crt_1) VNG6445G(crt_2) VNG7060 VNG7149
HSL: OE3560F(idiA) OE6213R(idiB2)
HMA: rrnAC3484(idi)
HWA: HQ2772A(idiA) HQ2847A(idiB)
NPH: NP0360A(idiB_1) NP4826A(idiA) NP5124A(idiB_2)
HLA: Hlac_1959
HUT: Huta_0419
HMU: Hmuk_1568
HTU: Htur_0774 Htur_4151
NMG: Nmag_1947 Nmag_2726
HVO: HVO_2506
HJE: HacjB3_06290
TAC: Ta0102
TVO: TVN0179
PTO: PTO0496
PHO: PH1202
PAB: PAB1662
PFU: PF0856
TKO: TK1470
TON: TON_0135
TGA: TGAM_1826(fni)
TSI: TSIB_1231
ABI: Aboo_0726
RCI: LRC397(fni)
APE: APE_1765.1(fni)
SMR: Smar_0822
SHC: Shell_1645
IHO: Igni_0804
DKA: DKAM_1356
TAG: Tagg_1387
HBU: Hbut_0539
SSO: SSO0063
STO: ST2059
SAI: Saci_0091
SIS: LS215_2222
SIA: M1425_2057
SIM: M1627_2137
SID: M164_2064
SIY: YG5714_2183
SIN: YN1551_0736
SII: LD85_2324
MSE: Msed_2136
PAI: PAE0801
PIS: Pisl_1093
PCL: Pcal_0017
PAS: Pars_0051
CMA: Cmaq_0231 Cmaq_1145
TNE: Tneu_0048
TPE: Tpen_0272
ASC: ASAC_0331
NMR: Nmar_0313
KCR: Kcr_1016
 |
|---|
Reference
Authors
Title
Journal
Organism
Sequence
|
1 [PMID:11158573]
Kaneda K, Kuzuyama T, Takagi M, Hayakawa Y, Seto H.
An unusual isopentenyl diphosphate isomerase found in the mevalonate
pathway gene cluster from Streptomyces sp. strain CL190.
Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 932-7.
Staphylococcus aureus, Streptomyces sp.
NCBI-GI: 12539425 (Staphylococcus aureus)
NCBI-GI: 12539423 (Streptomyces sp. CL190) |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:6351725]
Bishop JM.
Cellular oncogenes and retroviruses.
Annu. Rev. Biochem. 52 (1983) 301-54. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13792054]
AGRANOFF BW, EGGERER H, HENNING U, LYNEN F.
Biosynthesis of terpenes. VII. Isopentenyl pyrophosphate isomerase.
J. Biol. Chem. 235 (1960) 326-32.
Saccharomyces cerevisiae [GN:sce] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 5.3.3.2
IUBMB Enzyme Nomenclature: 5.3.3.2
ExPASy - ENZYME nomenclature database: 5.3.3.2
BRENDA, the Enzyme Database: 5.3.3.2
CAS: 9033-27-6 |
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