KEGG   ENZYME: 6.2.1.4Help
Entry
EC 6.2.1.4                  Enzyme                                 
Name
succinate---CoA ligase (GDP-forming);
succinyl-CoA synthetase (GDP-forming);
succinyl coenzyme A synthetase (guanosine diphosphate-forming);
succinate thiokinase;
succinic thiokinase;
succinyl coenzyme A synthetase;
succinate-phosphorylating enzyme;
P-enzyme;
SCS;
G-STK;
succinyl coenzyme A synthetase (GDP-forming);
succinyl CoA synthetase;
succinyl coenzyme A synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
succinate:CoA ligase (GDP-forming)
Reaction(IUBMB)
GTP + succinate + CoA = GDP + phosphate + succinyl-CoA [RN:R00432]
Reaction(KEGG)
Substrate
GTP [CPD:C00044];
succinate [CPD:C00042];
CoA [CPD:C00010]
Product
GDP [CPD:C00035];
phosphate [CPD:C00009];
succinyl-CoA [CPD:C00091]
Comment
Itaconate can act instead of succinate, and ITP instead of GTP.
Pathway
Citrate cycle (TCA cycle)
Propanoate metabolism
Metabolic pathways
Biosynthesis of secondary metabolites
Microbial metabolism in diverse environments
Orthology
K01899  
succinyl-CoA synthetase alpha subunit
K01900  
succinyl-CoA synthetase beta subunit
Genes
HSA: 
8801(SUCLG2) 8802(SUCLG1) 8803(SUCLA2)
PTR: 
452711(SUCLA2) 460492(SUCLG2) 470417(SUCLG1)
PPS: 
100971297(SUCLA2) 100973485(SUCLG2) 100985425(SUCLG1)
GGO: 
101127943 101128782(SUCLA2) 101143056(SUCLG1)
PON: 
100171525(SUCLA2) 100173831(SUCLG1) 100443464(SUCLG2)
MCC: 
693991(SUCLG1) 697454(SUCLG2) 704434(SUCLA2)
MMU: 
20916(Sucla2) 20917(Suclg2) 56451(Suclg1)
RNO: 
114597(Suclg1) 361071(Sucla2) 362404(Suclg2)
CFA: 
475775(SUCLG1) 476562(SUCLG2) 485448(SUCLA2)
AML: 
FCA: 
101084188(SUCLG1) 101088732(SUCLG2) 101096373(SUCLA2)
BTA: 
509983(SUCLG1) 511090(SUCLA2) 537713(SUCLG2)
SSC: 
397026(SUCLG2) 399539(SUCLG1) 399540(SUCLA2)
ECB: 
100050430 100063955(SUCLG2) 100067584
MDO: 
100019343 100029052 100030644
SHR: 
100915499(SUCLA2) 100923653(SUCLG1) 100930947(SUCLG2)
OAA: 
100075539 100078564 100079574
GGA: 
416087(SUCLG2) 422932(SUCLG1)
MGP: 
100538831 100548125 100550609
TGU: 
100224467 100225534(SUCLG2) 100227336(SUCLA2)
ACS: 
100555196 100559792 100561742
XLA: 
447333(sucla2) 494796(suclg1) 734975(suclg2)
XTR: 
394842(sucla2) 496495(suclg2) 594977(suclg1)
DRE: 
317746(suclg2) 406299(sucla2) 436850(suclg1)
TRU: 
101063974 101071250 101075271
OLA: 
101158169 101161764 101170834
BFO: 
BRAFLDRAFT_117780 BRAFLDRAFT_124275 BRAFLDRAFT_208919
CIN: 
100175858 100180260 100184967
SPU: 
581428 581456 581673
DME: 
Dmel_CG10622(Sucb) Dmel_CG1065(Scsalpha) Dmel_CG11963(skap) Dmel_CG6255
DPO: 
Dpse_GA10444 Dpse_GA23007 Dpse_GA23751 Dpse_GA26331
DAN: 
Dana_GF10458 Dana_GF17693 Dana_GF22035 Dana_GF24225
DER: 
Dere_GG13653 Dere_GG14126 Dere_GG15160 Dere_GG15952
DPE: 
Dper_GL12039 Dper_GL14403 Dper_GL21555 Dper_GL25295
DSE: 
Dsec_GM13912 Dsec_GM14589 Dsec_GM23771 Dsec_GM26905
DSI: 
Dsim_GD13190 Dsim_GD13780 Dsim_GD18581
DWI: 
Dwil_GK11971 Dwil_GK16245 Dwil_GK17298 Dwil_GK20526
DYA: 
Dyak_GE20552 Dyak_GE21380(Dyak_Scsalpha) Dyak_GE25125 Dyak_GE25915
DGR: 
Dgri_GH12731 Dgri_GH16246 Dgri_GH16428 Dgri_GH23962
DMO: 
Dmoj_GI10056 Dmoj_GI12510 Dmoj_GI13181 Dmoj_GI14987
DVI: 
Dvir_GJ11957 Dvir_GJ12416 Dvir_GJ15342 Dvir_GJ23792
AGA: 
AgaP_AGAP001312 AgaP_AGAP004352 AgaP_AGAP004744
AAG: 
AaeL_AAEL005552 AaeL_AAEL006833 AaeL_AAEL011746
CQU: 
CpipJ_CPIJ005779 CpipJ_CPIJ006157 CpipJ_CPIJ018673
AME: 
551403(Scsalpha) 551958
NVI: 
100122377(NV12734) 100123453(NV13707)
TCA: 
659315 660087 661403
API: 
100168560 100168788 100168943(Scsalpha)
PHU: 
Phum_PHUM148770 Phum_PHUM168040 Phum_PHUM173270
ISC: 
IscW_ISCW011750 IscW_ISCW015999 IscW_ISCW020686
CEL: 
CELE_C05G5.4(sucl-1) CELE_C50F7.4(sucg-1) CELE_F23H11.3(sucl-2) CELE_F47B10.1(suca-1)
CBR: 
CBG00458 CBG07585 CBG15175 CBG17559
BMY: 
Bm1_00350 Bm1_00840
TSP: 
Tsp_03823 Tsp_06006
SMM: 
Smp_052060 Smp_060820 Smp_167330
NVE: 
NEMVE_v1g163681 NEMVE_v1g208385 NEMVE_v1g246109
HMG: 
100204599 100206952 100212510
TAD: 
TRIADDRAFT_25488 TRIADDRAFT_55336 TRIADDRAFT_61514
AQU: 
100634721 100639406 100641457
ATH: 
AT2G20420 AT5G08300 AT5G23250
ALY: 
ARALYDRAFT_480870 ARALYDRAFT_487662 ARALYDRAFT_489184
GMX: 
100527938 100782001 100790952 100815484
MTR: 
MTR_6g077820
CSV: 
101205496 101206269
RCU: 
RCOM_0258610 RCOM_1669290 RCOM_1669400
POP: 
POPTR_422788 POPTR_553334 POPTR_730613 POPTR_827745 POPTR_831388
VVI: 
100248061 100261358 100261494
OSA: 
4330016 4343710
DOSA: 
Os02t0621700-01(Os02g0621700) Os07t0577700-01(Os07g0577700)
BDI: 
100835038 100843332
SBI: 
SORBI_02g037420(SORBIDRAFT_02g037420) SORBI_04g026360(SORBIDRAFT_04g026360)
ZMA: 
100216609 100273271 100283329 100284286 100284826
SMO: 
SELMODRAFT_122224 SELMODRAFT_405593 SELMODRAFT_408824 SELMODRAFT_419323
PPP: 
PHYPADRAFT_104557 PHYPADRAFT_209911 PHYPADRAFT_212421
CRE: 
CHLREDRAFT_196570(SCLA1) CHLREDRAFT_24101(SCLB1a)
VCN: 
VOLCADRAFT_104417(sclb1) VOLCADRAFT_107577(scla1)
OLU: 
OSTLU_30915 OSTLU_31367
OTA: 
Ot03g05850
CME: 
CMH132C CMT209C
SCE: 
YGR244C(LSC2) YOR142W(LSC1)
AGO: 
AGOS_AEL211W AGOS_AFR134C
ERC: 
Ecym_4557 Ecym_5568
KLA: 
KLLA0A05478g KLLA0E03235g
LTH: 
KLTH0G02464g KLTH0H00880g
PPA: 
PAS_chr2-2_0407 PAS_chr3_0831
VPO: 
Kpol_1050p74 Kpol_440p13
ZRO: 
ZYRO0D11352g ZYRO0F13596g
CGR: 
CAGL0F08107g CAGL0I07139g
NCS: 
NCAS_0E03800(NCAS0E03800) NCAS_0H02300(NCAS0H02300)
NDI: 
NDAI_0B00990(NDAI0B00990) NDAI_0C01360(NDAI0C01360)
TPF: 
TPHA_0A05220(TPHA0A05220) TPHA_0E01470(TPHA0E01470)
TBL: 
TBLA_0B02220(TBLA0B02220) TBLA_0C06560(TBLA0C06560)
TDL: 
TDEL_0A03420(TDEL0A03420) TDEL_0G01060(TDEL0G01060)
KAF: 
KAFR_0B04370(KAFR0B04370) KAFR_0E02520(KAFR0E02520)
DHA: 
DEHA2G10384g DEHA2G23584g
PIC: 
PICST_66961(LSC2) PICST_69303(LSC1)
PGU: 
PGUG_02787 PGUG_04080
LEL: 
LELG_01441 LELG_03227
CAL: 
CaO19.10866(LSC1) CaO19.3358(LSC1) CaO19.710(LSC2) CaO19.8329(LSC2)
CTP: 
CTRG_00671 CTRG_04465
CDU: 
CD36_01550 CD36_32310
COT: 
CORT_0B10480 CORT_0D04850
YLI: 
YALI0D04741g YALI0E24013g
CLU: 
CLUG_02473 CLUG_03602
NCR: 
NCU01227 NCU08471 NCU09810
SMP: 
SMAC_00014 SMAC_03928 SMAC_08470
PAN: 
PODANSg5971 PODANSg6609 PODANSg8268
TTT: 
THITE_2108018 THITE_2123869
MTM: 
MYCTH_2296474 MYCTH_2301810 MYCTH_2312147
MGR: 
MGG_05480 MGG_16230
FGR: 
FG02030.1 FG07898.1 FG10885.1
NHE: 
NECHADRAFT_54871 NECHADRAFT_69004 NECHADRAFT_72513
VAL: 
VDBG_05569 VDBG_09517
SSL: 
SS1G_06854 SS1G_07524 SS1G_07857
BFU: 
BC1G_04587 BC1G_05074 BC1G_15906
ANI: 
AN1193.2 AN2295.2 AN7000.2
NFI: 
NFIA_014810 NFIA_028840 NFIA_036970 NFIA_045340
AFM: 
AFUA_1G10830 AFUA_4G00290 AFUA_4G04520 AFUA_5G06130
AOR: 
AOR_1_1080184(AO090009000644) AOR_1_550074(AO090038000330) AOR_1_610144(AO090023000354) AOR_1_66044(AO090206000040)
ANG: 
ANI_1_230154(An17g01670) ANI_1_58124(An14g00310)
AFV: 
AFLA_048610 AFLA_068760 AFLA_107660 AFLA_115170
ACT: 
ACLA_009460 ACLA_024680 ACLA_053840 ACLA_078590
PCS: 
Pc12g06870 Pc13g06650 Pc13g13290 Pc20g10080
CIM: 
CIMG_06044 CIMG_06921 CIMG_08546
CPW: 
CPC735_026160 CPC735_033080 CPC735_062050
PBL: 
PAAG_00417 PAAG_01463 PAAG_03040
URE: 
UREG_02609 UREG_04332 UREG_05927
ABE: 
ARB_02840 ARB_06073 ARB_07144
TVE: 
TRV_00293 TRV_04876 TRV_04944
AJE: 
HCAG_01746 HCAG_07697 HCAG_08548
PNO: 
SNOG_07991 SNOG_08494 SNOG_15384
PTE: 
PTT_09097 PTT_17669 PTT_19429
ZTR: 
MYCGRDRAFT_56933(LSC2) MYCGRDRAFT_67374 MYCGRDRAFT_74730(LSC1)
TML: 
GSTUM_00004464001 GSTUM_00008015001
SPO: 
SPAC16E8.17c SPCC1620.08
CNE: 
CNA07260 CNG02080
CNB: 
CNBA7060 CNBG2700
CGI: 
CGB_A8350W CGB_G4001W
LBC: 
LACBIDRAFT_300566 LACBIDRAFT_301769
MPR: 
MPER_11085 MPER_12266
CCI: 
CC1G_04425 CC1G_10272
SCM: 
SCHCODRAFT_13366 SCHCODRAFT_47353
UMA: 
UM00368.1 UM01672.1
MGL: 
MGL_2351 MGL_3165
PGR: 
PGTG_00377 PGTG_05991
MBR: 
MONBRDRAFT_16401 MONBRDRAFT_20070 MONBRDRAFT_21309
NGR: 
NAEGRDRAFT_29455 NAEGRDRAFT_79109 NAEGRDRAFT_83245
DDI: 
DDB_G0271842(scsC) DDB_G0274449(scsB) DDB_G0289325(scsA)
DPP: 
DICPUDRAFT_156596 DICPUDRAFT_158646 DICPUDRAFT_159229
PFA: 
PF11_0097 PF14_0295
PFD: 
PFDG_02825 PFDG_03168
PFH: 
PFHG_00507 PFHG_04701
PYO: 
PY02175 PY05049
PCB: 
PC000095.02.0 PC001331.02.0 PC302362.00.0
PBE: 
PB000281.02.0 PB001002.01.0
PKN: 
PKH_090570 PKH_131870
PVX: 
PVX_084960 PVX_091100
PCY: 
PCYB_091540 PCYB_132710
TAN: 
TA02815 TA10625
TPV: 
TP01_0677 TP04_0660
BBO: 
BBOV_III007780(17.m07682) BBOV_IV010490(23.m06275)
TGO: 
TGME49_090600 TGME49_109750
TET: 
TTHERM_00068140 TTHERM_00079540 TTHERM_00437600 TTHERM_00535260
PTM: 
GSPATT00001403001 GSPATT00001822001 GSPATT00004885001 GSPATT00009157001 GSPATT00014000001 GSPATT00017703001 GSPATT00025345001 GSPATT00027937001 GSPATT00031530001
TBR: 
Tb10.6k15.3250 Tb927.3.2230(Tb03.48O8.710)
TCR: 
507681.20 507767.10 508479.340
LMA: 
LMJF_25_2130 LMJF_25_2140 LMJF_36_2950
LIF: 
LINJ_25_2220 LINJ_25_2230 LINJ_36_3100
LDO: 
LDBPK_252220 LDBPK_363100
LMI: 
LMXM_25_2130 LMXM_25_2140 LMXM_36_2950
LBZ: 
LBRM_25_1700 LBRM_25_1710 LBRM_35_3170
TVA: 
TVAG_047890 TVAG_144730 TVAG_165340 TVAG_183500 TVAG_259190 TVAG_318670
PTI: 
PHATRDRAFT_26921 PHATRDRAFT_42015(SCS-alpha)
TPS: 
THAPSDRAFT_31362(SCS1) THAPSDRAFT_411(SCS2)
PIF: 
PITG_02026 PITG_08881
 » show all
Taxonomy
Reference
1
  Authors
Hager, L.P.
  Title
Succinyl CoA synthetase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 387-399.
Reference
2  [PMID:13084656]
  Authors
KAUFMAN S, GILVARG C, CORI O, OCHOA S.
  Title
Enzymatic oxidation of alpha-ketoglutarate and coupled phosphorylation.
  Journal
J. Biol. Chem. 203 (1953) 869-88.
  Organism
Sus scofa [GN:ssc]
Reference
3  [PMID:13768680]
  Authors
MAZUMDER R, SANADI DR, RODWELL VW.
  Title
Purification and properties of hog kidney succinic thiokinase.
  Journal
J. Biol. Chem. 235 (1960) 2546-50.
  Organism
Sus scofa [GN:ssc]
Reference
4  [PMID:13181903]
  Authors
SANADI DR, GIBSON M, AYENGAR P.
  Title
Guanosine triphosphate, the primary product of phosphorylation coupled to the breakdown of succinyl coenzyme A.
  Journal
Biochim. Biophys. Acta. 14 (1954) 434-6.
  Organism
Sus scofa [GN:ssc], Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9014-36-2
DBGET integrated database retrieval system