KEGG   ENZYME: 1.5.4.1Help
Entry
EC 1.5.4.1                  Enzyme                                 

Name
pyrimidodiazepine synthase;
PDA synthase;
pyrimidodiazepine:oxidized-glutathione oxidoreductase (ring-opening, cyclizing);
pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a disulfide as acceptor
BRITE hierarchy
Sysname
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)
Reaction(IUBMB)
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one + glutathione disulfide + H2O = 6-pyruvoyltetrahydropterin + 2 glutathione [RN:R03984]
Reaction(KEGG)
Substrate
2-amino-6-acetyl-3,7,8,9-tetrahydro-3H-pyrimido[4,5-b][1,4]diazepin-4-one [CPD:C02587];
glutathione disulfide [CPD:C00127];
H2O [CPD:C00001]
Product
6-pyruvoyltetrahydropterin [CPD:C03684];
glutathione [CPD:C00051]
Comment
In the reverse direction, the reduction of 6-pyruvoyl-tetrahydropterin is accompanied by the opening of the 6-membered pyrazine ring and the formation of the 7-membered diazepine ring. The pyrimidodiazepine formed is an acetyldihydro derivative. Involved in the formation of the eye pigment drosopterin in Drosophila melanogaster.
History
EC 1.5.4.1 created 1990, modified 2014
Pathway
ec00480  Glutathione metabolism
ec00790  Folate biosynthesis
Orthology
K00310  pyrimidodiazepine synthase
Genes
APLC: 110980055 110980113
SKO: 102805287
DME: Dmel_CG6673(GstO2) Dmel_CG6776(GstO3) Dmel_CG6781(se)
DPO: Dpse_GA19859
DAN: Dana_GF10161 Dana_GF24330 Dana_GF24331
DER: Dere_GG14320 Dere_GG14321 Dere_GG15075
DPE: Dper_GL15503 Dper_GL15504 Dper_GL15566 Dper_GL15567
DSE: Dsec_GM24931 Dsec_GM24932 Dsec_GM25061 Dsec_GM25062
DSI: Dsimw501_GD12980(Dsim_GD12980) Dsimw501_GD14099(Dsim_GD14099) Dsimw501_GD14100(Dsim_GD14100)
DWI: Dwil_GK20354 Dwil_GK20355 Dwil_GK20540
MDE: 101891696
AGA: AgaP_AGAP005749(GSTO1)
AAG: 23687505
AME: 552118(GstO1)
BIM: 100745560
BTER: 100646742
SOC: 105200535
AEC: 105147922
ACEP: 105622284
PBAR: 105424214
HST: 105185767
CFO: 105256274
LHU: 105676415
PGC: 109858549
NVI: 100116224(GstO1)
DPA: 109534346
NVL: 108564623
BMOR: 100141441(GSTo4) 692819(GSTo1) 692941(GSTo2) 732973(GSTo3)
API: 100167548
DNX: 107163884
 » show all
Taxonomy
Reference
1  [PMID:6438092]
  Authors
Wiederrecht GJ, Brown GM.
  Title
Purification and properties of the enzymes from Drosophila melanogaster that catalyze the conversion of dihydroneopterin triphosphate to the pyrimidodiazepine precursor of the drosopterins.
  Journal
J. Biol. Chem. 259 (1984) 14121-7.
Reference
2  [PMID:16712527]
  Authors
Kim J, Suh H, Kim S, Kim K, Ahn C, Yim J
  Title
Identification and characteristics of the structural gene for the Drosophila eye  colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases.
  Journal
Biochem. J. 398 (2006) 451-60.
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.4.1
IUBMB Enzyme Nomenclature: 1.5.4.1
ExPASy - ENZYME nomenclature database: 1.5.4.1
BRENDA, the Enzyme Database: 1.5.4.1
CAS: 93586-06-2
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