KEGG   Felis catus (domestic cat): 101098403Help
Entry
101098403         CDS       T02385                                 

Gene name
HK1
Definition
(RefSeq) hexokinase-1 isoform X2
  KO
K00844  hexokinase [EC:2.7.1.1]
Organism
fca  Felis catus (domestic cat)
Pathway
fca00010  Glycolysis / Gluconeogenesis
fca00051  Fructose and mannose metabolism
fca00052  Galactose metabolism
fca00500  Starch and sucrose metabolism
fca00520  Amino sugar and nucleotide sugar metabolism
fca00524  Neomycin, kanamycin and gentamicin biosynthesis
fca01100  Metabolic pathways
fca01200  Carbon metabolism
fca04066  HIF-1 signaling pathway
fca04910  Insulin signaling pathway
fca04930  Type II diabetes mellitus
fca04973  Carbohydrate digestion and absorption
fca05230  Central carbon metabolism in cancer
Module
fca_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
fca_M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose
Brite
KEGG Orthology (KO) [BR:fca00001]
 Metabolism
  Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    101098403 (HK1)
   00051 Fructose and mannose metabolism
    101098403 (HK1)
   00052 Galactose metabolism
    101098403 (HK1)
   00500 Starch and sucrose metabolism
    101098403 (HK1)
   00520 Amino sugar and nucleotide sugar metabolism
    101098403 (HK1)
  Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    101098403 (HK1)
 Environmental Information Processing
  Signal transduction
   04066 HIF-1 signaling pathway
    101098403 (HK1)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    101098403 (HK1)
  Digestive system
   04973 Carbohydrate digestion and absorption
    101098403 (HK1)
 Human Diseases
  Cancers
   05230 Central carbon metabolism in cancer
    101098403 (HK1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101098403 (HK1)
Enzymes [BR:fca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.1  hexokinase
     101098403 (HK1)
Membrane trafficking [BR:fca04131]
 Autophagy
  Mitophagy
   Other mitophagy associated  proteins
    101098403 (HK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Hexokinase_2 Hexokinase_1 CSD
Motif
Other DBs
NCBI-GeneID: 101098403
NCBI-ProteinID: XP_006937896
Ensembl: ENSFCAG00000004927
UniProt: A0A2I2UHA4
LinkDB All DBs
Position
D2
AA seq 922 aa AA seqDB search
MGQSCQRGCSEEASEKPIKPPLTEAKIDKYLYAMRLSDETLIDIMTRFKKEMKNGLSRDF
NPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEQNQNVHMESEIYDTP
ENIVHGSGSQLFDHVAECLGDFMEKKKIKDKKLPVGFTFSFPCRQSKIDEAILITWTKKF
KASGVEGMDVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTN
ACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEK
MVSGMYLGELVRLILVKMAKEGLLFEGRITPELLTRGKFKTSDVSAIEKNKEGLHNAKEI
LTRLGVEPSDDDCISVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGS
LYKTHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLA
HFRLTKDMLLEVKKRMRAEMDMGLRKQTHEKAVVKMLPSFVRSTPDGTEHGDFLALDLGG
TNFRVLLVKIRSGKKRTVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPR
MPLGFTFSFPCKQTSLDAGILITWTKGFKATDCVGHDVATLLRDAIKRREEFDLDVVAVV
NDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMLEGDEGRMCINMEWGAFGDN
GCLDDIRTLYDRLVDEYSLNAGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEP
LKTRGIFQTKYLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCG
AGMAAVVDKIRENRGLDHLSVTVGVDGTLYKLHPHFSRIMHQTVQELSPNCNVSFLLSED
GSGKGAALITAVGVRLREESSS
NT seq 2769 nt NT seq  +upstreamnt  +downstreamnt
atggggcagagctgccagcgaggatgcagtgaagaagcatctgaaaagcccatcaagccc
ccacttactgaagctaagattgacaagtatctctatgccatgcggctctccgatgaaact
ctgatagatatcatgactcggttcaagaaggagatgaagaatggcctctcccgggatttt
aatccaacagccacagtgaagatgttgccaacgtttgtaaggtctattcctgatggttca
gaaaagggagatttcattgccctggatcttggcgggtcttcctttcgaattctgagggtg
caagtgaatcatgagcaaaaccagaatgttcacatggagtccgagatttatgacaccccg
gagaacatcgtgcacggcagtggaagccagcttttcgatcacgtcgccgagtgcctggga
gacttcatggagaagaagaaaatcaaggacaagaaattacctgtgggattcacgttttcc
ttcccttgtcggcagtccaaaatagacgaggccatcctgatcacctggacaaagaaattt
aaagcgagcggagtggagggaatggatgtggtgaagctgcttaacaaagccatcaaaaag
cgcggggactacgatgccaacattgtggccgtggtgaacgacacggtggggaccatgatg
acctgtggctacgacgaccagcagtgcgaagtcggcctcatcattggcactggcaccaac
gcgtgctacatggaggaactgaggcacattgacctggtggaaggcgacgagggcaggatg
tgcatcaacacggagtggggggcctttggggacgacgggtccctcgaagacatccgcacc
gagttcgaccgggagatagaccgtggctctctcaaccctgggaagcagctgtttgagaag
atggtgagtggcatgtacttgggggagctggttcgactgatcctggtcaagatggccaag
gagggcctcttatttgaaggacggatcaccccggagctgctcaccagggggaagttcaag
accagtgatgtgtcagccattgaaaagaataaggaaggcctccacaatgccaaagaaatc
ctgacccgcctgggagtggagccatctgatgacgactgtatttcagtccagcacgtgtgt
accattgtctcatttcgctctgccaacctggtggctgcaacgctgggcgccatcttgaac
cgccttcgagataacaagggcacacccaggctgcggaccacggttggtgtcgacgggtct
ctttacaagacgcacccacagtattcacgacgtttccacaagactctgaggcgcttggtg
cccgactccgatgtgcgcttcctcctctcggagagcggcagcggcaagggggccgccatg
gtcaccgcggtggcctaccgcctggccgagcagcaccggcagatcgaggagaccctggcc
cacttccgcctcaccaaggatatgctgctggaggtgaagaagagaatgcgggccgagatg
gacatgggcctgaggaaacagacgcacgaaaaggccgtagtcaagatgctgccctccttc
gtccggagcactccagacgggaccgagcatggtgacttcttggcccttgatcttggagga
acgaatttccgtgtcttactggtgaaaatccgcagtgggaaaaagagaacggtggaaatg
cacaacaagatctatgccattcccattgaaatcatgcagggcactggggaagagctgttt
gaccacatcgtctcctgcatctccgacttcctggactacatggggatcaaaggccccaga
atgcctctcggcttcacgttctcattcccctgcaagcagacgagcttggatgcgggaatc
ttgatcacctggacgaagggttttaaggcaaccgactgcgtggggcacgatgtagcaacc
ttactaagggatgcgatcaaaaggagagaggaatttgacctggacgtggtggctgtggtc
aatgacacggtgggcaccatgatgacctgtgcttatgaagagcctacctgcgaggttgga
ctcatcgtagggactggcagcaacgcctgctacatggaagaaatgaagaatgtcgagatg
ctggagggggacgaggggcgaatgtgcatcaacatggagtggggtgcctttggggacaac
gggtgtctcgatgacatcagaactctctatgacagactggtggatgaatattctctaaac
gctggaaaacaaaggtttgagaagatgatcagcggtatgtacctgggtgagatcgtccgc
aacatcttgatcgacttcaccaagaaggggttcctcttccgagggcagatctctgagccg
ctgaagactcgcggcatttttcagaccaaatatctctcccagattgagagtgaccgatta
gcactgctccaggtccgggccatcctccagcagctgggcctgaatagcacctgtgacgac
agtatcctcgtcaagaccgtgtgcggggtggtgtccaaacgggccgcgcagctgtgcggt
gcgggcatggccgccgtggtggacaagatccgcgagaacagagggctggaccatctcagt
gtgactgtgggggtggatggaacactctacaagcttcatccgcacttctcgagaatcatg
caccaaaccgtgcaggaactgtcaccgaactgcaacgtgtccttcctcctgtccgaagac
ggcagcggcaagggggctgccctcatcacggccgtgggcgtccggctccgggaagaatcg
agcagctaa

DBGET integrated database retrieval system