Heterocephalus glaber (naked mole-rat): 101725481 Help Entry 101725481         CDS       T02812                                  Symbol Rnf213 Name (RefSeq) ring finger protein 213   KO K22754   E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27] Organism hgl  Heterocephalus glaber (naked mole-rat) Brite KEGG Orthology (KO) [BR:hgl00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hgl04121]     101725481 (Rnf213) Enzymes [BR:hgl01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      101725481 (Rnf213) Ubiquitin system [BR:hgl04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    Other single Ring-finger type E3     101725481 (Rnf213) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  ZnF_RZ-type zf-C3HC4 zf-RING_2 zf-C3HC4_3 AAA AAA_5 AAA_22 zf-C3HC4_2 zf-RING_UBOX zf-C3HC4_4 AAA_7 ABC_tran Nudix_N_2 Prok-RING_4 zf-RING_6 PduV-EutP Motif Other DBs NCBI-GeneID:  101725481 NCBI-ProteinID:  XP_012933580 LinkDB All DBs Position Un AA seq 5150 aa AA seqDB search MECPRCRHVSSEQAPKFCSQCGQRLLLAAPAPDADAENNPLVCSAPKGERALGEAPKEND DLHSIPGSSDWQENLEDPESDTPWILVQKSKRKGKKKKNQNMSDSSELSSWFSSLSDSSS QSLLSSPGSLDAATPHSQAPQGDPAGQLGQAQDWRLLPLEGGHPLVPLVGGPEAATGGMP QELPGGQDLRATVPSGDRGSLAERSSSTASGSEDHPAASDVTQQSESRRDGCGSKEEAQK DGQQAESPASRGMNATAEPANKANEAIKDMQGKTQTVKQPPDSPVVPKEPCQRVEAKGKL AVAGEKTSENANVKLEDVRKEEESNRAQPVAVKNKEQRNQSTTTQEVTASTLGPGEGVTV YFHAIIAKQFAFDPSCHRVFVRGDGLGRPKWKNACEMHCTKVLEENECLIEGSMVIPKQS VNCPIPYKYVIVKGQDSGEYEFIYKKQKKGEHVNRCLYMPAHLVFAGEWHQYDDVCMKPP GRFQKAKDWFTDGTRKEVVAGKHMATVVMLDRIFSVLQTWSLINLKTFLNQFLQFYSVVR EPVVHQEKKEIWSDLQYTEKEVKQHLWEHLKKHMAPFVKGKDGDALPEDSPVKSKLRMGL IVLSIVGKIHISLSKSDISFLSYLLVPAACSPDALHSDLDHFRSTTERWQEYLVNLCQQC MEEGVHQWLGTLPVLHYCMQLSPAKNEPVVHLEDTWAALEGIPFSKFREDTTYQNELLQF VEKKKHLLYVDDYLFRSWFSLLPLRALAQYIEKATEFLTLVPAHVLDCFLGLDYRLAELQ ISHQNVADVENVFKKLLQLVDTYHGVILEETLVQCYLPLCLKLHEGVCSSTGDYRFYEIP ALSAELICRMTKLQPLQDTAGPGAEASRAMFQSALTATRSWLRKVLKMNMLYSVPSAAMF SYPTEIKIWRRLVDIDFPEAHGWKRSLLGDMEGRLKQATPRLQISAFCSTLWDATSPDDS VARSFKNCVFEAVNSACQSQTSILEGLSCLDCQKLGVLMSAVVTKSWPRSSGQAVEDPDE ILKYLLTWRDVEQLFKLYGTNEKILASITEESQKLMAVADSVFTKVAGDLHDGTILVGQL ELILKHKSQFLSIWELKRKCPSVQKTQCDLKEVLDCRMVDLWVLKREARWVDSLLKLCGK TRHLIPVDFGEMEAMHSEDLSTKRLNEAVTVTLPMFPASNYRTHYNLSSQVQEMAEKIDL LKDSHIFQILWEEAAEKLSSPIEELERQSLQFPEVYAYLYFPCYQRFTELYHNLRLGKVT FATINDVFKDFVDKYGDLDSDLQVMCLMDPLAQRDWIPVRIGQIREYHSLHQAISSAKVI QKVKKNFELTGDFSVLRILLNFNDDFQSFCCETLDQISPQLVRAKKKLQDISEPRRRCLE ELSLQRELVSWLHEALEGINELKVFVDLASISAGENDIDVDRVACFHDAVQGYACLLYDL DRTAGFEVFMKHLTELWKALDNDPNLPRKLRDSARNLEWLKTVKESHGSVELSSLTLAKA INSKGIYMIKAPKSGQKISPDAVLSLMLPESHGGLEEVRSYSLEELKDLLNKLMLMSGKK DHNNEEVERFSEVFSGMQRLLQAFLNLYTAGSMLFRTWTAEVYCCPRRGKSIRMDFGLKL VTQLSDSGDVTACLEALCRQMEHFLDRWKRFVTEKRAEHFYLNFYTAEQLVYLSTELRKR YPSEPALTMLSFIKSSCTPHDVVRAVEEYDSEASTHCVRTVVAELPLQLSSEGSLEARLR LIMEQSLRCLPAFLPGCLDLDALGRCLAHLAGMGGPPVERHLPHGLHVGQPNLVLCGHSE VLLAALAIYMQAQDEPLPTFDEVLLCTPETTFEEVALLLRRCLTPGAQGHKVYSLLFADQ LSYEVACQGEALFHSLRTQHHREDYQLVMVCDAAREHCLLPSAFSRHKALLTPQASLPDI QAYLEQHYKVPKPSLSAASVFRDQTCVGIVASERAGVGKSLYVKRLHGKLEEKFNGRMMP LKVIRLNDPKVDENQVLGSLLPFLEARYQQTPMIFHFDVTASVQTGIWVFLFKLLILQYL MDINGKMWLRNPRHLYIVEILERKTVLPKMASNTSMHALLFSFLDIFPKVTCRPPKEVID LELSAKRSRKEPGMDKRKFRSETFQRPYQYLRRFHQNENLDTFQYQEGSVEGTPEECVQH LLIYCGVVNPSWSELRNFARFLNCQLRDCEASVFCNAGFIGDTLRGFKNFVVTFMVFMAR DFATPTLHTSDQSPGNYAVTMDGVEEEDLAPFSLRKRWESEPHPYIFFNGDRVTMTFMGF YLQPNNNGSIDAINHLNGRVIKRNVMTSELYRGLLLQRVPFNINFDNLPRHEKLERLCQA LGIQWVTDPDETYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRAG AKTDTMKLVKVHGGTTPRMVYSSVREAEKIAFVNKGQLQLDTILFFDEANTTEAISCIKE VLCDRTVDGQPLINNSGLHIIAACNPYRKHSQEMICRLESAGLGYRVSAEETAEKLGSIP LRQLVYRVHALPPSLIPLVWDFGQLNDTAERLYIQQIVQRRVDSSLIDDSGIHVITEVLS ASQGFMRQRENECSFVSLRDVERCVRIFQWFYERSNMLLVNLTKFLCKSGASKNTYKRDP VLWSLVLAIGICYHASLEKKDPYRRTICRFLPEPYKDSKVILDEITQAQDLFLNGVPLRK TIAKNLALKENVFMMIICIELKIPLFLVGKPGSSKSLAKTIVADAMQGQAAHSDLFRSLK QVHLVSFQCSPHSTPQGIIGTFRQCARFQQGKNLEQYVSVVVLDEVGLAEDSPKMPLKTL HPLLEDGCIEDDPAPHKKVGFIGISNWALDPAKMNRGIFVSRGIPNEKELIDSAKGICSS DNLLLDRIQAYFGPFARAYKTVCQTQDKEFFGLRDYYSLIKMIFATAKASNKKPSPQDIA QAVLRNFSGKDDIQALDIFTASLPEARYIEEVSTIELIKQNIYGGPERATGTELEDTEAR YLLVLTKNYVALQILQRTFFDEDQQPEIIFGSSFPQDQEYTQICRNINRVKICMETGKMV VLLNLQNLYESLYDALNQYYVYLGGQKYVDLGLGTHRVKCRVHPAFRLIVIEEKDVVYQQ FPVPLINRLEKHFLDIHTVLEHWQKDIVRRLMDWAQEFSDVKAGPFLAGHKYSPADVFIG YHSDACASVVLQATERQGPRPEKEELDRKVMEEAKLILLDCATPDAVVRLGTSALGTFAA AMLSHEYYYRQEHNSFADFLQAHLRAAGLERQAIFTEITTFSRLLTSHDCEILASEVAGL APKPTILSLQQFDTEHSFLRAVRNCLASKASCKILIIQTDFDDGFYSAQLIASAKYSALN EINKTQGKNSCVFVYFITKLSRMGSGASYVGFHGGLWQSVHIDDLQRSTVMASDVTQLQT ITLSQLFEPNNKPEWEGNQEEEMETDPSRSGEAAETEMEVKSPEEMEIEPSDQKGGSVQV LDTTKLLRSCVQGAVAMLRDQNEGCTRNMRRVVILLSLLNEDNDCNAFFLRVSKMRLHVL LKKQEENQPCSVKEWVTREASNQEALQEAGTFRHTLWKRVQGAITPLLASMIALLDRDAN LELLSRPDLPTWAQDLWMLIFSDDKLLDIPLVHSLRSKSDMSSILVENCMAGNTSNDIPF SWRIKDYLEELCIQAQYITHAEGLPQKLVEIFQQTPLGLFLTQLPERQQVELLHSYSNDF LLLTMKVSTMEELKFLQMALWSCLRELQEALGQPEGALSLPWVHLAYQHFRTRLQNFSRI LTIHPSVLHSLTEAAPKHNLAGREMTLDVFAAMACVEKLTEDTLEPSPQAWLQLVKNLSM PLELICSDGYLQGSGNMTRALIGEIRAQWNRIFSISLFVEHVLLGTESQVPELSELVTKY VFLLNKCLQENSDIKMHEPFVAVMTTLCECKDRASSTFTRFGIHPCSICLGDAQDPVCLP CDHVYCLACIKPWLASGEDLCPYCLTNLPDNFSPTISQEYREAVEKHAHFRRMCNSFFVD LVSTMCFKDNAPPQKKVIDSLLSLLFVQKEFPKVAPRGCREHTKTLSPFNDVVDKTPVIR SVVLKLLLKYSFQEVKNYIQDYLSLLESKAFIFEDKTELYMLFINCLEDSIYEKTSSCSR NNELSYLREEAHFLQSCSPRRHGQGPATVASVEYLQELARIRLCLDRASDFLAELPEGSE LAEERQCYLQQVKQFCDRSGNDWYRVYLVRRLSSQRGMDFVQGLCRQGHPCHWVFPKGVT EQKDHLSQMDGYLVYGEEYKAVRDAVGHAMLQLKTTGIGTALMACRSPRPQQAAYLLLAL YREVAVLFCSQSEDLHPTPKQCEAMNKFIEESKLLSPEIQRFATPLVNNILPLLNSGPGS SRLEGTVAEMAIHAAVVLLCGQNGVLAPLRNLAFSPANMKNAYLPTMPEDLLFQARHWMG LKHLQWYTCPNGHPCTVGECGRPVQQAVCVDCHAQIGGLNHKPEAGFQMTLDNKDRTQSG HVLGKPQPRGVAVVPDRELSPVVFILLRLLTHLALLLGAAHSPQALGNIIKPPVEDPKAF LQQHIQRDLEQLTKMLGKNADETSLVVHLMLRRLLRTQQPTSGQKTLNFSAQLSTKDERN NWEKYTEALLLPELEHLDKTLLTMNTLISQDERISSSPVAKIIFGDPATFLLHLPQNSAT HCSKIWSCRKKITVEYLQHIVEQKNGKETLPVLWNFLQKEAELRLVKFLPEILALQKSLV KQFQNVPEIESASIRKFIKSHSSDGLKKLFEERITIFLSTWNALRRSLETHGEIKLPKEY CSSDLDLDTDFEVILPRRRGLGLCSTALVSYLIHLHNEVVYMVEKFSKENSSYSVDASEI TDVHVISYDVERDLIPLILSNCQYQVVQGGETSQEFDLEKIQRQVRGRLLQGKPRLTVKG IPTLVHRHDQNYERLFMDIKNKMKQSALQSAAMGTISGQLQSFSDACEALSVIEVTLGFL STAGGDPNMQLNMYIQEVLRMGDQTTSVLKALSRCQLKHSIALWQFLSAHKSEQLLRLKK EPFREISPRYKEDLTPEHARLLSTFLNHSSLDTFLLELHEMMVLKLKNTQAEDTFNPKWS LRDTLVSYMETKDSEVPPDLESQFPEEILLSSCVSVWKAAATRKRDRQAR NT seq 15453 nt NT seq  +upstreamnt  +downstreamnt atggagtgcccgaggtgccgccacgtctccagcgagcaagcccctaaattctgcagccag tgtggacagcggctgctgctcgcagctcctgcgccagatgcagatgctgagaacaacccc ttggtgtgctcagcccccaaaggagagagagcgctcggagaagcaccgaaggagaatgac gacctgcattcgatcccaggctcctctgactggcaggaaaatttagaggatcctgaatcg gacaccccctggatcctcgtccaaaagagtaaaaggaagggaaagaagaaaaagaatcag aacatgtctgattcctcggagctgagttcctggttctcatctctctctgactcttcaagt caaagtttgctttcaagccctggctctctggatgcagccacgccccacagccaagccccg cagggtgacccggctggccagcttggtcaggcccaggactggcggctgctgccgttggag ggtggccacccccttgtcccccttgtcggagggcctgaggcagccacgggaggcatgccc caggagctcccgggagggcaggacctcagggccaccgtgccctctggagaccgaggctcc cttgcggagaggtccagctcaactgcctctggctctgaagaccaccctgcggcttcggat gtcactcagcagtctgagtccagaagggacggttgtgggtccaaggaggaagcacagaag gatggacagcaggcagagtcgccagcgtccagaggaatgaatgctacagctgagccagct aacaaagccaacgaggccatcaaggatatgcagggcaagactcagacagtcaaacagcca ccagacagccccgttgtgcccaaggagccctgccagagagtggaagccaagggcaagtta gctgttgctggggaaaaaaccagtgaaaatgcgaatgtgaagctagaagacgtgaggaag gaggaagagagtaacagagctcaaccagtggctgtgaaaaacaaggagcagaggaaccag agcaccactacgcaggaggtcacagcgagcacgctgggcccgggggaaggagtcaccgtg tacttccacgccatcatcgccaagcaatttgcatttgaccccagctgccaccgagtgttt gtgcgtggtgatggacttgggaggccaaaatggaaaaatgcgtgtgagatgcactgcacc aaggtcttagaggagaatgagtgtctcatcgagggcagcatggtcattcccaagcagagc gtgaactgtcccatcccatacaagtacgtcattgtcaaaggccaagactccggggagtat gaattcatctacaagaagcagaagaaaggcgagcatgtcaaccgctgtctgtacatgccg gcccacctggtatttgcaggagaatggcatcaatatgatgacgtctgcatgaagcctcct gggaggtttcagaaagccaaggactggttcactgatgggacgaggaaggaggtggtggct gggaagcacatggcgactgtggtcatgctggaccgcatcttcagtgtcctgcagacctgg agcctcatcaacctgaagacctttctcaaccagttcctgcaattctactctgtcgtccga gagcctgtggttcaccaagagaagaaggagatatggagtgatctgcagtacacggagaag gaggtgaaacaacacctgtgggagcatttgaagaagcacatggccccgtttgtgaaaggc aaggatggggacgccctgcctgaggactccccggtgaagagcaaactgcggatgggcctg attgtcctttccatagtgggaaaaattcacatttccttgtccaaatctgacatctccttc ctgagctacctcctggtccctgctgcctgttcaccagacgccctgcacagcgacctagac cacttccgcagcacaactgagaggtggcaagagtacctggtaaacctgtgccaacagtgc atggaagagggagtccaccagtggctgggcaccctgccggtcctgcactactgcatgcag ctctcccctgccaagaacgagccagtggtccacctggaggacacttgggcggccctggaa ggaatccccttctcgaagtttcgggaagacacaacctatcagaatgaattgctgcagttt gtggaaaagaagaaacatttgctatatgtggatgactaccttttccggtcctggtttagt ttgctgcctctgagagccctggctcaatacatagaaaaggccaccgagttcctgaccctt gtgcccgctcacgtgctggactgtttcctggggctcgactatcggctggcagaacttcag atctctcaccaaaatgtggcggatgtcgagaatgtttttaagaagctgttgcaactcgtg gacacttaccatggcgtaattctggaggagactctggtgcagtgctacctgcctttgtgc ctcaaactgcatgaaggtgtctgcagcagcacgggagactacaggttctatgaaatcccg gccttatctgcagagctcatctgcaggatgactaaacttcaaccactacaggacactgca ggcccaggggcagaagccagcagggctatgttccagagtgctctgactgccactcgaagc tggctcaggaaagtgttgaaaatgaacatgttgtactcagtgccgtcggctgccatgttc tcttaccccacggagattaagatctggcggcggctggtggacatagacttccctgaggcc catggctggaaaaggtcactgctgggagacatggaagggagactcaagcaggcgacgccc cgcctccagatctctgccttctgcagcactctgtgggatgccaccagccctgacgacagt gtggccaggagcttcaagaattgtgtcttcgaagctgtgaactccgcctgccagtctcag accagcatcctcgaaggactctcctgtcttgattgccagaaacttggcgtcctcatgtcc gctgtggttaccaagtcctggccccggagcagcgggcaagcagtggaggacccagacgag attctgaaatacctgctcacgtggcgagatgtggagcagctcttcaaactgtacggaacc aatgagaaaattttagccagtattacagaggaaagccagaagttgatggcagtagccgac tctgtgtttacgaaagtagctggtgacctccatgatgggaccattttagttggacaattg gagctgatcctgaagcataagtctcagtttctgagcatctgggaactgaagagaaaatgt ccttcagttcaaaagacccagtgcgatttgaaggaagtgctggactgcagaatggtggac ctgtgggttctaaagagagaggcgagatgggtcgacagcctcctgaagctgtgtgggaag acgagacacctgataccagtggactttggagagatggaagcaatgcactctgaagacctc agcaccaagaggctaaacgaagctgtgaccgtgacactgcccatgttcccagcctccaat tacaggacacattacaacctgagctcccaggtccaagaaatggccgaaaagatagacctg ctgaaagacagccacatctttcagatcctatgggaagaggctgcggagaagctgagcagt ccgatagaggaattggaacggcagagcctgcaatttcccgaggtctacgcatacttgtac tttccttgttaccaaaggttcaccgaactgtatcacaatctgaggttgggaaaggtcacc tttgccacaatcaatgacgtcttcaaggactttgtagataaatatggcgacttggactcc gacctccaggtcatgtgtcttatggatcccctggcccaaagggactggatccctgtgcgc atcgggcagatcagggagtaccacagcctgcaccaggccatcagctcggccaaggtcatc cagaaggtcaagaagaactttgaattgaccggggacttcagcgtgcttcgcattttatta aactttaatgatgacttccagagcttttgctgtgagacactggaccagatcagcccacag cttgtccgggccaagaagaagctgcaggacatcagtgagccgcgacggcgctgtctggag gagctgtccctgcagagagagcttgtcagctggctccacgaggcgctcgaaggcatcaac gaactcaaagtgtttgtggacctggcctccatctcagcgggggagaacgacatcgatgtg gaccgcgtggcctgcttccatgatgccgtgcagggctacgcctgcctactgtatgatctg gacaggacagcaggcttcgaggtgttcatgaaacatctgacagagctctggaaggcccta gacaacgacccaaacctgcccagaaagctgcgagattctgccaggaacttggagtggctg aagacagtcaaggaaagccatgggtccgtagagctgtcgtccctgaccctggccaaagca atcaacagcaagggcatctacatgatcaaggcacccaaaagtggccagaagatttccccg gatgctgtcctgagcttgatgctccctgagagtcacggtggcctggaggaagtgcgcagc tactctttggaagagctgaaggaccttttgaataagctgatgctgatgtctggcaagaaa gaccacaacaacgaggaagtggagaggttttcagaggtgttctctggcatgcagcggctc ctgcaggccttcctcaacttatacactgccggcagcatgctctttaggacctggacggct gaggtttactgctgtcccaggagaggtaaatccatccgcatggactttggcttgaagctg gtgacccagctgtcagacagtggggacgtcaccgcatgcctggaagccctctgcaggcag atggagcattttctggaccgctggaagagattcgtgacagagaagcgtgctgagcacttt tacctcaacttctacactgctgagcagctggtctacctgagcaccgagctccggaagcgc taccccagcgagcccgccctgaccatgctgtccttcatcaaaagcagctgcaccccacat gatgtcgtaagggccgtggaggagtacgacagtgaggcttccacacactgcgtgaggacc gtggtggcagaactaccactgcagctgagctctgagggcagcctggaggccaggctgcgg ctcatcatggagcagtccctgcgctgccttcctgccttcctgccgggctgccttgacctg gatgccctcggccgctgcctggctcacctggctgggatgggcgggccccccgtggagcgg catctcccacacggcctgcacgtgggccagcccaacctcgtcttgtgtggccactctgag gtgctgctggccgctctggccatctacatgcaggcccaggatgagcccctgcccaccttt gatgaggtgcttctgtgtaccccagagaccacgtttgaggaggtggcactgctcctacgc cgctgcctcaccccaggtgctcaaggtcacaaggtctacagcctgctgtttgcagaccag ctgagttatgaggtggcctgccagggagaggcgctcttccacagcctgcgcacacagcac caccgcgaggactaccagctggtcatggtctgtgatgcagcccgggagcactgcctcctc ccctctgccttcagccggcacaaagccctcctcaccccgcaggcatctctccctgacatc caggcctacctggagcagcactacaaggtcccaaagccaagcttgtcggcagcttcagtg ttcagagaccagacgtgtgttggaatcgtggcctccgagagagcgggtgtcggaaagtct ctctatgtgaagagactgcatggcaaactggaagagaagttcaacggtagaatgatgcct ttgaaagttattcggttgaatgaccctaaggtggatgagaaccaagtcctgggctccctc ctgcctttcttggaagcacgataccagcagacgcccatgatattccacttcgacgtgact gcttctgtacagactggaatttgggtctttcttttcaaactcctcattttacaatacctc atggatataaatgggaaaatgtggcttcggaacccacgccatttatatatcgttgaaatc ctggaaagaaagacagtactgccaaagatggcttcaaatacgagtatgcatgcccttctg ttcagttttcttgacatcttccccaaagtcacctgcagacctcctaaagaagtgatagac ttggagctgtctgccaagaggagccgcaaagagcccggaatggataagagaaagtttcgc agtgagactttccagaggccttaccaatatttaagacggttccaccaaaacgagaacctg gacacctttcagtaccaggaaggctccgtggaaggcaccccagaggagtgcgtccagcac ctcctgatttactgtggggtggtaaacccgtcctggtcggagcttcggaacttcgctcgc ttcttaaactgtcagctcagagactgtgaggcctctgtgttctgcaatgcagggtttatt ggggacacactgaggggcttcaagaactttgttgtaaccttcatggtcttcatggcgaga gactttgccacaccgacactgcacacctctgaccaaagcccagggaattatgcggtcacc atggatggggttgaggaagaagacctagcccccttctctctccgaaagaggtgggaatca gagcctcatccatatattttcttcaatggcgaccgtgtgaccatgaccttcatgggcttc tatctccagcccaataacaatggcagcattgatgccatcaatcacttgaatgggagagta atcaagagaaatgtcatgacctcagagctgtacagggggctgttgcttcagagggtgccc ttcaatattaattttgataacctgcccagacatgagaaacttgaaaggctttgccaggcg ctagggatccagtgggtcactgaccctgatgaaacctatgagcttacaacagacaatatg cttaagatcctggccattgaaatgcgattccgctgtgggatcccagtaattatcatggga gaaaccggctgtgggaaaacgagactcattaagttcctcagtgatctgcggcgtgctggt gccaagactgacaccatgaagctggtcaaggtccatggaggaacgactcccaggatggtc tactccagtgtcagggaggccgagaagattgcctttgtcaataagggccaactccagttg gacaccatcttgttcttcgacgaagccaacacaacagaagccataagctgtatcaaagaa gttctgtgtgacagaacagtggacggccagccgctgataaacaactcgggtttgcacatc atagctgcctgcaacccttaccggaagcactctcaggagatgatctgccgcctcgagtct gcaggtttgggatatcgcgtcagtgctgaggagacggcagagaagctgggctccatcccg ctaaggcagctggtgtaccgggtccacgctctgccgccaagcctgattcctctggtgtgg gactttggacaactgaatgacactgccgagaggctctacatccaacagattgtccagaga cgggtggattcctcgctgatagatgacagcgggattcacgtgatcacagaagtgctctcg gcctcgcagggcttcatgaggcagagagaaaatgagtgcagttttgtcagcctccgggac gtggagcgctgtgtcagaatcttccagtggttctacgagcgcagcaatatgctcttggta aacctgaccaaatttctctgcaagtctggtgccagcaaaaatacctacaagagagatccg gtcctctggtccctggtgctggccatcgggatctgttaccatgcctctttggaaaagaaa gacccctaccggagaaccatctgcaggtttctaccagaaccgtacaaggacagcaaggtg atcctggatgagatcactcaggcacaagatctttttctgaatggtgtacccctcaggaaa accatagccaagaatttggctttgaaagagaatgtcttcatgatgatcatctgcattgag ctgaagatccccctcttcctggtggggaagcccggcagctccaagtctctcgccaagacc atagtggcagacgccatgcaaggtcaggctgcacactccgatctcttccgcagcctgaag caggtccacctggtgtcctttcagtgcagcccgcactctactccccaaggtatcattggc accttcaggcagtgtgcccgcttccagcagggtaagaacctggagcagtatgtctctgtg gtggtgctggatgaggtgggactagctgaagactcccccaaaatgcccctgaagacatta caccccctgctggaagacggctgcattgaagatgaccctgccccccacaagaaagttggc ttcataggcatttccaattgggccctcgaccctgccaagatgaaccggggcatttttgtg tcacgtggcattcccaatgagaaagagctcatagacagcgccaagggtatctgctcttct gacaacctgcttctggacagaatccaagcgtacttcggcccctttgccagagcgtacaaa acagtgtgtcagacacaggacaaggagtttttcgggcttcgagactactacagcctcatc aagatgatctttgccacggccaaggcctctaataagaagccttccccacaggatatcgca caggctgtcctccggaacttcagtggcaaagatgacatccaggccttggacatcttcaca gccagtttaccagaggccaggtacatagaggaggtcagcaccatcgagctgatcaagcag aacatttatgggggtccggagagggcgacaggcacagagctggaagacaccgaggcccgc tacttactcgtgctgacgaagaactatgtggcactgcagatcctgcaacggaccttcttc gatgaagaccagcagccggagatcattttcggctccagctttccccaggaccaggagtac acacagatctgccgcaacatcaaccgggtgaagatctgcatggagacaggcaagatggtg gtgctgcttaacctacagaacctttatgagagcctgtatgacgcactcaaccaatactac gtctaccttgggggccagaagtatgtggacctcggcctgggcacccaccgagtcaagtgt cgggtccaccccgccttccgcctgatcgtcatcgaggagaaggacgtcgtgtaccagcag ttccctgtgcccctcatcaaccggctggagaagcacttcctggacatccacactgtgctg gagcactggcagaaggacatcgtgcgccgactcatggactgggcccaggagttctctgac gtgaaagcaggcccgttcctggctgggcacaagtacagccctgcggacgtcttcatcggc taccactcggatgcctgtgcctccgtggtgctgcaggccaccgagaggcagggtcccagg cctgagaaggaggagctggaccgcaaggtgatggaagaggccaagctgatcctgctggac tgcgccacgcccgacgctgtggtgcggctgggcacctccgctctgggcacgtttgccgca gccatgctgtcacacgagtactactaccggcaggagcacaactccttcgcagacttcctg caggctcaccttcgcgcggcgggcctggagcgccaagccatcttcaccgagatcaccact ttttccaggctgctgaccagtcacgactgtgaaatcttggcatcagaggtggcaggcctg gccccaaagcccaccatcctgtcactgcagcagtttgacacggagcactcgttcctcaga gcagtccgaaactgcttagcaagtaaagccagctgtaaaattctcatcattcagacagac ttcgacgatggcttttacagtgctcagctcattgcttctgccaagtattctgctctcaat gagatcaataaaacacaaggcaagaacagctgtgtcttcgtctattttatcactaaactg tcccggatgggaagtggagcatcctacgtgggattccatggagggctgtggcagtccgtg cacatcgatgacctccagaggtccacagtcatggcctcagacgtgacccagctgcagact atcaccctaagccagctgttcgagccaaacaacaaacctgagtgggaaggcaaccaggag gaagagatggaaacagaccccagcaggtcaggagaagcagccgagactgaaatggaagta aaaagtccggaggagatggagatcgaaccctcggaccagaaaggtggcagtgtgcaggtc ctggacaccaccaagttgcttcgaagctgcgtgcagggcgcggtggcaatgctcagggac cagaacgagggctgcacccgcaacatgaggagagtcgtcatcctcctgagccttctaaat gaagataatgactgcaacgcctttttcttgcgggtgtccaagatgcgcctccatgttctt ctgaagaaacaagaagagaaccagccttgcagtgtgaaggagtgggtgaccagggaggcc tcgaatcaggaagccctccaggaggcgggcacgttcaggcacaccctgtggaagcgagtc caaggagccatcacccctctcctggcgagcatgatagcgcttctcgacagagatgccaac ctggagctgctgagcaggccagatttaccaacctgggcacaagacctgtggatgttgatt ttcagtgatgacaagcttctggacattccgcttgtgcacagcctgagatctaagagtgac atgtcctccatcctggtggagaactgcatggctgggaacacctccaatgacatccccttt agctggagaatcaaggactacctggaagagctgtgtatccaggcccagtacatcacacat gccgaagggctgccgcagaagttagtggaaatcttccagcagacgcctctgggtttgttc ctcactcagctccctgaaaggcagcaggtagagctcctacacagctactcgaatgacttc ctgctcctgaccatgaaagtgtccaccatggaggagttgaagttcctgcagatggccctg tggtcttgcctgagggagctgcaggaggcactgggacagcctgagggggcgctctccttg ccgtgggtgcacctggcctaccagcacttcaggacgcggctgcagaacttctcccgaatc ttgaccatccatccctcagtcctgcacagcctcactgaggctgcaccgaagcacaacttg gctggccgtgagatgacactggacgtatttgcagcaatggcctgtgtggagaagctgaca gaagacaccttggagcccagtccccaggcctggctgcagctagtaaagaacctgtccatg ccgctggagctcatctgctcagatgggtacctgcaaggcagcgggaatatgaccagagct ctcatcggtgagatcagagcccagtggaatcgcatcttctccatttcgctcttcgtggag catgtgctcctagggaccgagagccaggtacctgagctgagcgagctggtgaccaagtac gtcttcttgctgaacaagtgtcttcaggagaactccgacatcaagatgcatgagcctttt gtagctgtaatgaccactctttgtgaatgcaaagaccgcgccagcagtacctttaccagg tttggtattcacccatgctccatctgcctgggagatgcgcaggaccccgtgtgcctgccc tgtgaccatgtgtattgcctggcctgcatcaaaccctggctggcctctggggaggactta tgcccctactgcttaaccaacctgccagacaacttctctccaaccatttcccaggagtac agggaggccgtggaaaagcacgcccacttccggcgcatgtgcaacagcttctttgtggac ctggtctccaccatgtgcttcaaggacaatgctccgcctcagaagaaagtgatcgatagc ctgctgtctttgctcttcgtacagaaggagttcccgaaagtcgccccacggggatgccgt gaacacacaaagactctttccccatttaatgacgttgtggataagactcctgtcatccgc tccgtggtgctaaagctgctgttgaagtacagcttccaggaagtgaagaattacattcag gactacctgtccctgctagagagcaaagcattcatcttcgaagacaaaactgaactatat atgctcttcatcaactgcctggaagattcgatatatgagaagaccagttcttgctccagg aacaatgagctgagctacctgagggaggaagcccatttcctccagtcttgctcccctaga agacatggccagggaccggccactgtggcctccgtggagtacttgcaggagttggccagg atccgcctgtgtctcgacagggcttctgacttcctcgcagagcttccagagggctcagag ctggctgaggagcggcagtgctacctacagcaggtaaagcagttctgtgaccgcagcggg aacgactggtaccgagtgtacctggtgaggagactctccagccagcgcgggatggatttc gtgcagggcctctgcaggcagggccacccctgccactgggtgtttcccaagggagtcacg gagcagaaggaccatctaagccagatggatggatacttggtgtatggtgaggaatacaag gccgttcgtgatgctgtgggccatgccatgctccagctaaagaccacaggcatcgggact gctctgatggcctgcaggagccccaggccccagcaagcggcctacttactgctggcgctg taccgagaagtggctgttctgttctgctcccaaagcgaagacctgcaccctacgcccaag caatgtgaagctatgaataaattcattgaggaaagcaaactcctctctcctgagatccaa cgctttgccacacccctcgtgaacaatatcctgcctctgctgaactcagggcctggctcc agcaggcttgaagggacagtggcagaaatggccattcatgctgcagttgtccttctgtgt ggacagaatggagtcctggcgcccctaaggaatttggccttctccccagccaacatgaag aatgcttatcttccaaccatgcctgaagacctgctgttccaggcgaggcactggatgggt ctgaaacatctccagtggtacacttgtcccaatggtcacccgtgcaccgtgggagagtgt ggcaggccagtgcagcaggccgtgtgtgtggactgtcatgctcaaatcggaggcctgaat cacaaacccgaagccggctttcagatgaccctagacaacaaagacagaactcagagtggc cacgtgctgggcaaaccacagcccagaggtgtggccgtggtgcctgaccgggagctgtcg ccagtggtcttcattctcctgcggctgctcactcatttggctctgcttctaggagctgcc cacagtccccaggctctggggaacatcattaagcctccagtcgaggacccgaaggctttc ctacagcagcacatccagagggatctggagcagctgaccaagatgctaggcaagaatgcg gatgagaccagccttgtggtccaccttatgctgcgcagactcctcaggacccagcaaccc acttcgggccagaagactttaaattttagtgcacaattatcgaccaaagatgagagaaac aattgggaaaaatacacggaagctcttctcttacctgagctggagcatctagataaaacc ctgctcaccatgaatactctcatcagccaagatgaacgcatcagctccagccccgtggcc aaaatcatattcggtgacccggcgaccttccttctccacctgccccagaacagcgctacc cactgctctaagatctggagctgcaggaagaagatcacagttgagtacctccagcacatc gtggagcagaagaacggcaaagaaacactgcccgtgctctggaatttcctgcagaaggag gcagaactgaggctggtgaaatttttgcctgagattctggccctacaaaagagcttagtg aaacaattccagaatgttccagaaattgaatccgcctccatccgaaagtttattaaaagt cacagttcagatgggctgaagaagttgtttgaggagaggattactatttttctgtccacg tggaatgcactgaggcgatcactggagacccatggtgagatcaagctccctaaagagtac tgcagctctgacttggatctggacactgattttgaagtcatcctgccacgtcggcggggc ctgggcctctgctctactgctttagtcagctacttgattcacctacacaatgaagttgtc tacatggtggagaagttctccaaggaaaacagcagctattctgtggatgcctccgagatc actgatgtgcacgtcatcagttacgatgtggagcgtgacctgatcccgctgattctgtcc aactgccagtatcaagtggtgcaaggtggggagacctcacaggagtttgacttggaaaag atccagcgtcaggtcaggggtcgcctcctgcagggcaagcccaggctgacggtcaagggg atccccacactggtgcacagacatgaccagaactatgagcgtctcttcatggacatcaag aacaagatgaaacagagtgccctccagagtgcagctatgggcaccatcagtgggcagctg cagtccttcagtgatgcctgtgaagccctctctgtcatagaagtcaccttgggctttctg agcacagctggcggggacccaaacatgcagctgaatatgtacatccaagaagtcctgcga atgggtgaccagacaacttcagttttaaaggccctaagcagatgtcagttaaaacacagc attgccctctggcagtttctgtctgcgcataagtcggaacagctgctgcgcctgaagaaa gaaccatttcgggaaatcagtccaaggtataaagaggatctcaccccagaacatgccagg ctcctcagcactttcctaaaccacagcagcctagacaccttcctcctggagctccacgaa atgatggtgctaaagctgaagaacactcaggccgaggacaccttcaaccccaagtggagc ctgagggacactctggtaagttacatggaaactaaagacagtgaagtccctccagatttg gaatcccagttcccagaagagatactgctgtccagctgcgtctctgtgtggaaagccgct gccacacggaagcgggaccgacaagcaaggtag

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