Homo sapiens (human): 134 Entry 134               CDS       T01001                                  Gene name ADORA1, RDC7 Definition (RefSeq) adenosine A1 receptor   KO K04265   adenosine A1 receptor Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04024   cAMP signaling pathway hsa04071   Sphingolipid signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04923   Regulation of lipolysis in adipocytes hsa04924   Renin secretion hsa05032   Morphine addiction Drug target Adenosine (DG00243):  D00045 D02300 D02769 Aminophylline (DG01062):  D00227 D05429 Apaxifylline:  D02964 Bamifylline (DG01064):  D03051 D07491 Caffeine (DG00974):  D00528 D01453 D07603 Choline theophyllinate:  D02017 Doxofylline:  D03898 Enprofylline:  D04006 Proxyphylline:  D01771 Selodenoson:  D05818 Tecadenoson:  D06019 Theophylline (DG01061):  D00371 D01712 D06103 D06104 Tonapofylline:  D09684 Trabodenoson:  D10493 Brite KEGG Orthology (KO) [BR:hsa00001]  Environmental Information Processing   Signal transduction    04071 Sphingolipid signaling pathway     134 (ADORA1)    04024 cAMP signaling pathway     134 (ADORA1)    04022 cGMP - PKG signaling pathway     134 (ADORA1)   Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     134 (ADORA1)  Organismal Systems   Endocrine system    04923 Regulation of lipolysis in adipocyte     134 (ADORA1)    04924 Renin secretion     134 (ADORA1)  Human Diseases   Substance dependence    05032 Morphine addiction     134 (ADORA1) G protein-coupled receptors [BR:hsa04030]  Class A. Rhodopsin family   Base and nucleoside    Adenosine     134 (ADORA1) SSDB Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 7TM_GPCR_Srx CcmH Other DBs NCBI-GeneID:  134 NCBI-ProteinID:  NP_000665 OMIM:  102775 HGNC:  262 Ensembl:  ENSG00000163485 Vega:  OTTHUMG00000042125 Pharos:  P30542(Tclin) UniProt:  P30542 LinkDB Position 1q32.1 AA seq 326 aa MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL KIWNDHFRCQPAPPIDEDLPEERPDD NT seq 981 nt   +upstreamnt  +downstreamnt atgccgccctccatctcagctttccaggccgcctacatcggcatcgaggtgctcatcgcc ctggtctctgtgcccgggaacgtgctggtgatctgggcggtgaaggtgaaccaggcgctg cgggatgccaccttctgcttcatcgtgtcgctggcggtggctgatgtggccgtgggtgcc ctggtcatccccctcgccatcctcatcaacattgggccacagacctacttccacacctgc ctcatggttgcctgtccggtcctcatcctcacccagagctccatcctggccctgctggca attgctgtggaccgctacctccgggtcaagatccctctccggtacaagatggtggtgacc ccccggagggcggcggtggccatagccggctgctggatcctctccttcgtggtgggactg acccctatgtttggctggaacaatctgagtgcggtggagcgggcctgggcagccaacggc agcatgggggagcccgtgatcaagtgcgagttcgagaaggtcatcagcatggagtacatg gtctacttcaacttctttgtgtgggtgctgcccccgcttctcctcatggtcctcatctac ctggaggtcttctacctaatccgcaagcagctcaacaagaaggtgtcggcctcctccggc gacccgcagaagtactatgggaaggagctgaagatcgccaagtcgctggccctcatcctc ttcctctttgccctcagctggctgcctttgcacatcctcaactgcatcaccctcttctgc ccgtcctgccacaagcccagcatccttacctacattgccatcttcctcacgcacggcaac tcggccatgaaccccattgtctatgccttccgcatccagaagttccgcgtcaccttcctt aagatttggaatgaccatttccgctgccagcctgcacctcccattgacgaggatctccca gaagagaggcctgatgactag

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